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Atherogenesis and Aging

  • Book
  • © 1987

Overview

Editors:
  1. Sandra R. Bates

    1. Department of Physiology, University of Pennsylvania, Philadelphia, USA

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  2. Edwin C. Gangloff

    1. National Institutes of Health, USA

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    You can also search for this editor in PubMed   Google Scholar

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-xv
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  2. Introduction and Statement of Research Recommendations

    1. Introduction and Statement of Research Recommendations

      • Sandra R. Bates
      Pages 1-4

  3. An Overview of Atherosclerosis

    1. Front Matter

      Pages 5-5
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    2. The Pathogenesis of Atherosclerosis: Myths and Established Facts About Its Relationship to Aging

      • Robert W. Wissler, Dragoslava Vesselinovitch
      Pages 7-19

    3. Evolution and Progression of Atherosclerosis in the Coronary Arteries of Children and Adults

      • Herbert C. Stary
      Pages 20-36

    4. Noninvasive Imaging of Atherosclerosis in the Aged

      • David H. Blankenhorn
      Pages 37-47

    5. Perspectives in the Biology of Aging

      • Vincent J. Cristofalo
      Pages 48-56

    6. Effect of Age on Atherosclerosis Progression in Nonhuman Primates

      • Thomas B. Clarkson, Michael R. Adams, Kurt W. Weingand, L. Cheryl Miller, Sharon Heydrick
      Pages 57-71

  5. Alterations in the Arterial Wall with Aging

    1. Front Matter

      Pages 123-123
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    2. Alterations in the Arterial Wall with Aging

      • Richard W. St. Clair
      Pages 125-127

    3. Cultured Endothelial Cells as a Model for Aging and Atherogenesis

      • Elliot M. Levine, Stephen N. Mueller, James P. Noveral
      Pages 128-134

    4. Clonal Senescence of Vascular Smooth Muscle and Atherogenesis

      • George M. Martin
      Pages 135-145

  6. Aging in Intact Species

    1. Front Matter

      Pages 147-147
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    2. Criteria for Aging/Atherogenesis Animal Model

      • Edward J. Masoro
      Pages 149-153

    3. Age-Related Changes in Selected Animal Species

      • Dragoslava Vesselinovitch
      Pages 154-175

    4. Genetics of Human Aging and Premature Aging Syndromes: Relationship to Atherogenesis

      • W. Ted Brown
      Pages 176-182

  7. Environmental Modulators During Aging

    1. Front Matter

      Pages 183-183
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Keywords

About this book

Age is a nonreversible risk factor for atherosclerosis. The atherosclerotic process begins early in life, progresses during the middle years, and usually culminates in clinical disease towards the later years of the life span. Since atherosclerosis is a multifactorial disease, and many of the "risk factors" are time- and age­ related, it has been difficult to sort out intrinsic aging from environmental factors that operate over many years. Furthermore, the role of genetic factors remains unknown. This workshop has produced much worthwhile information that is helping elucidate the impact of age on atherogenesis. Important strides have been made in understanding the role of changes in the arterial wall and of lipoproteins, platelets, and monocyte-derived macrophages in the disease process. In parallel, our understanding of the biology of aging has increased sufficiently so that these two areas of interest can now profitably intersect. The proceedings of this successful workshop emphasize that there is much to be gained by continued interaction between those scientists interested in the biology of aging at all levels and those interested in the atherosclerotic process. Hopefully, we may eventually progress in our understanding and reach the stage when atherosclerosis will no longer be an inexorable concomitant of human aging. Edwin L. Bierman, M. D. Contents Foreword V Contributors IX Participants in the Workshop XV Introduction and Statement of Research Recommendations Sandra R.

Editors and Affiliations

  • Department of Physiology, University of Pennsylvania, Philadelphia, USA

    Sandra R. Bates

  • National Institutes of Health, USA

    Edwin C. Gangloff

Bibliographic Information

  • Book Title: Atherogenesis and Aging

  • Editors: Sandra R. Bates, Edwin C. Gangloff

  • DOI: https://doi.org/10.1007/978-1-4612-4652-7

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springler-Verlag New York Inc. 1987

  • Softcover ISBN: 978-1-4612-9099-5Published: 29 June 2012

  • eBook ISBN: 978-1-4612-4652-7Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XVI, 214

  • Topics: Cardiology, Biochemistry, general, Hematology, Human Physiology

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