Overview
- Editors:
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David R. Webb
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Roche Institute of Molecular Biology, Nutley, USA
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Carl W. Pierce
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Jewish Hospital, Washington University, St. Louis, USA
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Stanley Cohen
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University of Connecticut, Farmington, USA
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Table of contents (43 chapters)
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Front Matter
Pages i-xxviii
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Suppressor Factors
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- Masaru Taniguchi, Eiki Matsushita, Kenji Imai, Akihiko Koseki, Takayuki Sumida, Toshitada Takemori et al.
Pages 13-20
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- Makoto Iwata, Moriaki Akasaki, Paula Jardieu, Kimishige Ishizaka
Pages 21-31
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- Judith A. Kapp, Craig M. Sorensen, Carl W. Pierce, David R. Webb
Pages 33-46
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- Robert R. Rich, Edward J. Fox, Medhat N. ElMasry
Pages 59-71
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Interleukin 1
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- Steven B. Mizel, Jill Suttles, Judith Giri, Jon Lewis, Patricia Kilian, Kathryn A. Paganelli
Pages 73-81
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- Emil R. Unanue, Casey T. Weaver, Robert C. Fuhlbrigge, Jeanne-Marie Kiely, David D. Chaplin
Pages 97-104
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- Scott K. Durum, Alison Finnegan, Dan T. Brody, Elizabeth J. Kovacs, Mark R. Smith, Jay A. Berzofsky et al.
Pages 117-122
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B Cell Growth and Differentiation Factors
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- Tadamitsu Kishimoto, Tetsuya Taga, Kiyoshi Yasukawa, Yasuo Watanabe, Tadashi Matsuda, Koichi Nakajima et al.
Pages 123-136
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- Julian L. Ambrus Jr., Anthony S. Fauci
Pages 137-148
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- Tim R. Mosmann, Holly Cherwinski, Daniel Cher, Robert L. Coffman
Pages 149-159
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Interleukin 2
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Front Matter
Pages 160-160
About this book
The Fifth International Lymphokine Workshop was convened in Clearwater Beach, Florida, January 11-15, 1987. The theme chosen for the meeting was 'The Molecular Basis of Lymphokine Action," which reflected the opinion of the organizers as to how far the field had moved since the first Lymphokine Workshop only eleven years ago. As was evident at the last Lymphokine Workshop held in 1985, the contribution of molecular biology, particularly in the cloning of lymphokine genes, continues to play an important role in clarifying the structure of lymphokines, providing recombinant (read "pure") proteins for biological studies, and suggesting directions for studies of the molecular basis of lymphokine activity. The most recent lymphokines to yield to molecular cloning meth odology were the B-cell growth and differentiation factors, in partic ular BSF-1 or, as it is sometimes termed, interleukin 4. One of the surprises from this research is the broad spectrum of activities that can be attributed to this molecule, aside from its effects on B-cells, thus perhaps justifying its being called an interleukin. The interleukin 2 symposium demonstrated that even in a well-established research area, controversy and excitement can continue, when evidence was presented by several investigators indicating the presence of a second "converter" protein that changes the affinity of the now classical Tac antigen from a low to a high affinity IL-2 receptor.
Editors and Affiliations
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Roche Institute of Molecular Biology, Nutley, USA
David R. Webb
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Jewish Hospital, Washington University, St. Louis, USA
Carl W. Pierce
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University of Connecticut, Farmington, USA
Stanley Cohen
