Biology of Copper Complexes

1. Front Matter

   Pages i-xix

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2. Physiologic Aspects of Copper Complexes

   1. Front Matter

      Pages 1-1

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   2. A Physiological Basis for Pharmacological Activities of Copper Complexes: An Hypothesis

      • John R. J. Sorenson

      Pages 3-16

   3. Regulation of Ceruloplasmin Synthesis by Retinoic Acid and Interleukin-1

      • Robert J. Cousins, Ellen F. Barber

      Pages 17-30

   4. Role of Ceruloplasmin in Copper Transport

      • Edward D. Harris

      Pages 31-41

   5. Copper and the Regulation of Superoxide Dismutase Activity in Aortic Tissue

      • Charles T. Dameron, Edward D. Harris

      Pages 43-55

3. Biochemical Aspects of Copper Complexes

   1. Front Matter

      Pages 57-57

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   2. Influence of Diet and Inflammation on Serum Copper Enzymes

      • Robert A. Disilvestro

      Pages 59-66

   3. Copper and Connective Tissue: The Mechanism of Lysyl Oxidase

      • Frederick T. Greenaway, Coleen Young O’Gara

      Pages 67-79

   4. Copper — A Modulator of Peptide Release in the Brain

      • Ayalla Barnea

      Pages 81-93

   5. Copper-Dependent α-Amidation in the Synthesis of Neuroendocrine Peptide Hormones

      • Thomas R. Gibson, Christopher C. Glembotski

      Pages 95-107

4. Back Matter

   Pages 108-111

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5. Copper Complexes in Essential Metalloelement Nutriture and Disease States

   1. Front Matter

      Pages 113-113

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   2. Indices for Assessing Copper Nutriture in Animals and Humans

      • J. Cecil Smith Jr.

      Pages 115-126

   3. Dietary Simple Sugars Increase the Severity of Copper Deficiency in Experimental Animals

      • Meira Fields

      Pages 127-140

   4. Hypertension Induced Alterations in Copper and Zinc Metabolism: A Link to Vascular Disease?

      • Carl L. Keen, Michael S. Clegg, Fay Ferrell, Glenn C. Hunter, Michael A. Dubick

      Pages 141-153

   5. Manifestations of Copper Deficiency in Dairy Cattle

      • Alfred W. Anderson

      Pages 155-163

   6. Observations on Biological Effects of Low Dietary Copper in Nebraska Beef Cattle

      • J. L. Johnson, N. R. Schneider, A. R. Doster, M. P. Carlson, H. W. Leipold

      Pages 165-174

   7. Cuprous Sebacate Treatment of Menkes’ Disease

      • Darryl M. Williams, John R. Clement, F. Scott Kennedy, Harold Chen

      Pages 175-184

6. Biological Aspects of Copper and Iron in Inflammation

   1. Front Matter

      Pages 185-185

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In 1928, it was discovered that copper was essential for normal human metabolism. Ten years later, 1938, it was observed that patients with rheumatoid arthritis had a higher than normal serum copper concentration, which returned to normal wi th remission of this disease. Thirteen years later, it was found that copper complexes were effective in treating arthritic diseaseS. The first report that copper complexes had antiinflammatory activity in an animal model of in­ flammation appeared twenty-two years after the discovery of essen­ tiality. In 1976, it was suggested that the active forms of the anti­ arthritic drugs are their copper complexes formed in vivo. This suggestion was confirmed and extended in the interim with over 1000 recent publications, and many of these were addressed in the proceed­ ings of our first symposium, published in 1982. The present symposium was organized to present new normal physiological, nutritional, and biochemical aspects of essential metal­ loelement metabolism as well as variations in metabolism associated with disease states. In addition new data concerning antimicrobial, antiinflammatory, antiulcer, anticancer, anticarcinogenic, analgesic, and radioprotectant activities of copper complexes were presented. These activities are consistent with the notion that they represent the facilitation of normal copper-dependent metabolic processes in dis­ ease states. The presentations and interactive discussions that fol­ lowed are contained in these proceedings. John R. J. Sorenson Dedication These proceedings are dedicated to those who made this truly memorable scientific and social Arkansas experience possible.

• Arthritis
• Lipid
• biology
• enzymes
• inflammation
• metabolism
• receptor
• rheumatic diseases
• rheumatoid arthritis
• synthesis

• University of Arkansas for Medical Sciences, Little Rock, USA

  John R. J. Sorenson

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