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The alpha-1 Adrenergic Receptors

  • Book
  • © 1987

Overview

Editors:
  1. Robert R. Ruffolo

    1. Smith Kline & French Laboratories, Swedeland, USA

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Part of the book series: The Receptors (REC)

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-xx
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  2. Historical Perspectives

    1. Front Matter

      Pages 1-1
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    2. alpha-1 Adrenergic Receptors

      • William A. Pettinger, Donald D. Smyth
      Pages 3-16

  3. Characterization of the Receptor and Its Binding Site

    1. Front Matter

      Pages 17-17
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    2. Biochemistry and Pharmacology of the alpha-1 Adrenergic Receptor

      • David B. Bylund
      Pages 19-69

    3. Localizing the alpha-1 Adrenergic Receptor in the Central Nervous System

      • James R. Unnerstall
      Pages 71-109

  4. Biochemical Mechanism of Receptor Action

    1. Front Matter

      Pages 111-111
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    2. Ca2+ Utilization in Signal Transformation of alpha-1 Adrenergic Receptors

      • Pieter B. M. W. M. Timmermans, Martin J. M. G. Thoolen
      Pages 113-187

    3. Phosphoinositides and alpha-1 Adrenergic Receptors

      • James W. Putney Jr
      Pages 189-208

  5. Correlation of Receptor Binding and Function

    1. Front Matter

      Pages 209-209
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    2. Structure—Activity Relationships for alpha-1 Adrenergic Receptor Agonists and Antagonists

      • Robert M. DeMarinis, Margaret Wise, J. Paul Hieble, Robert R. Ruffolo Jr
      Pages 211-265

    3. Relationship of alpha-1 Adrenergic Receptor Occupancy to Tissue Response

      • Kenneth P. Minneman, Peter W. Abel
      Pages 267-324

    4. Heterogeneity of alpha-1 Adrenergic Receptors

      • J. Paul Hieble, William D. Matthews, Robert M. DeMarinis, R. Robert Ruffolo Jr.
      Pages 325-349

    5. Heterogeneity of alpha-Adrenergic Responsiveness in Vascular Smooth Muscle: Role of Receptor Subtypes and Receptor Reserve

      • N. A. Flavahan, P. M. Vanhoutte
      Pages 351-403

    6. alpha-1 Adrenergic Receptors in the Central Nervous System

      • E. Szabadi, C. M. Bradshaw
      Pages 405-453

  6. Regulation of Alpha-1 Adrenergic Receptors

    1. Front Matter

      Pages 455-455
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    2. Regulation of alpha-1 Adrenergic Receptors

      • Brian B. Hoffman
      Pages 457-474

  7. Agents interacting with alpha-1 Adrenergic Receptors

    1. Front Matter

      Pages 475-475
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    2. Therapeutic Applications of Agents Interacting with alpha-1 Adrenergic Receptors

      • J. Paul Hieble, Robert R. Ruffolo Jr.
      Pages 477-500

  8. Future Vistas

    1. Front Matter

      Pages 501-501
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Keywords

About this book

During the past decade, great strides have been made in our un­ derstanding of the biochemistry and pharmacology of the alpha-l adrenergic receptor. The alpha-l adrenergic receptor plays a key role in biological function. This is evidenced by the fact that the alpha-l adrenergic receptor plays a prominent functional role in most organs of the body and in the key systems responsible for survival of the organism and maintenance of optimum biological activity. This is most apparent in the cardiovascular system, in which alpha-l adrenergic receptors are the single most important receptor involved in the maintenance of blood pressure and circu­ latory function. It is appropriate, therefore, that recent findings related to the pharmacology and biochemistry of the alpha-l adrenergic receptor be compiled, since this subject has not been reviewed in detail in recent years. It is the purpose of this book to present a series of reviews of key experimental findings that shed new light on the alpha-l adrenergic receptor and the manner in which it functions. Classically, most receptors have been characterized based on structure-activity relationships obtained for selective agonists and antagonists interacting with the receptor. Although there are many newer and more sophisticated approaches to receptor char­ acterization, structure-activity relationships still provide impor­ tant information regarding the chemical requirements made by the receptor for its occupation by ligands and its subsequent acti­ vation by those ligands possessing intrinsic efficacy and, there­ fore, agonist activity.

Editors and Affiliations

  • Smith Kline & French Laboratories, Swedeland, USA

    Robert R. Ruffolo

Bibliographic Information

  • Book Title: The alpha-1 Adrenergic Receptors

  • Editors: Robert R. Ruffolo

  • Series Title: The Receptors

  • DOI: https://doi.org/10.1007/978-1-4612-4582-7

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Humana Press Inc. 1987

  • Hardcover ISBN: 978-0-89603-110-4Published: 08 January 1988

  • Softcover ISBN: 978-1-4612-8936-4Published: 05 October 2011

  • eBook ISBN: 978-1-4612-4582-7Published: 06 December 2012

  • Series ISSN: 1048-6909

  • Series E-ISSN: 2524-6488

  • Edition Number: 1

  • Number of Pages: XX, 544

  • Topics: Neurosciences

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