Pathology Reviews · 1989

1. Front Matter

   Pages i-viii

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2. Cell and Metabolic Disorders

   1. Front Matter

      Pages 1-1

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   2. Mammalian Glucocerebrosidase: Implications for Gaucher’s Disease

      • Robert H. Glew, Alakananda Basu, Karen L. LaMarco, Elizabeth M. Prence

      Pages 3-23

   3. Biology of Disease

      • Eduardo M. Castaño, Blas Frangione

      Pages 25-35

   4. Receptor-Mediated Endocytosis and Intracellular Processing of Insulin: Ultrastructural and Biochemical Evidence for Cell-Specific Heterogeneity and Distinction from Nonhormonal Ligands

      • Robert M. Smith, Leonard Jarett

      Pages 37-53

   5. Gastrin-Releasing Peptide (Mammalian Bombesin) Gene Expression in Health and Disease

      • Mary E. Sunday, Lee M. Kaplan, Etsuro Motoyama, William W. Chin, Eliot R. Spindel

      Pages 55-74

   6. Morphology and Biochemistry of Bone Remodeling: Possible Control by Vitamin D, Parathyroid Hormone, and Other Substances

      • William E. Huffer

      Pages 75-99

3. Inflammation and Immunity

   1. Front Matter

      Pages 101-101

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   2. Acute Inflammation and Microthrombosis Induced by Endotoxin, Interleukin-1, and Tumor Necrosis Factor and their Implication in Gram-Negative Infection

      • Myron I. Cybulsky, M. K. William Chan, Henry Z. Movat

      Pages 103-116

   3. Role of T Helper Lymphocytes in Autoimmune Diseases

      • Gérald J. Prud’homme, Nollaig A. Parfrey

      Pages 117-131

   4. Early Biochemical Events in Leukocyte Activation

      • Rebecca R. Sandborg, James E. Smolen

      Pages 133-153

   5. Nonimmunologic Mechanisms of Glomerular Injury

      • Jean L. Olson, Robert H. Heptinstall

      Pages 155-169

   6. The Pathogenesis of Atherosclerosis: Atherogenesis and Inflammation

      • J. Michael Munro, Ramzi S. Cotran

      Pages 171-183

4. Tumor Biology

   1. Front Matter

      Pages 185-185

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   2. The Role of Extracellular Proteases in Cell Proliferation and Differentiation

      • William Scher

      Pages 187-213

   3. Dietary and Nutritional Influences on Cancer: A Review of Epidemiologic and Experimental Data

      • Adrianne E. Rogers, Matthew P. Longnecker

      Pages 215-245

5. Advances in Methodology

   1. Front Matter

      Pages 247-247

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   2. Advances in Flow Cytometry for Diagnostic Pathology

      • John S. Coon, Alan L. Landay, Ronald S. Weinstein

      Pages 249-275

   3. Transgenic Mice—A Gold Mine for Furthering Knowledge in Pathobiology

      • R. Andrew Cuthbertson, Gordon K. Klintworth

      Pages 277-295

6. Back Matter

   Pages 297-299

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on the theories of Planck and Einstein. Rather, until The concept that human disease is a specialized branch of biology is universally accepted today, but in the mid-20th century, the accretion of individual historical perspective, is actually of recent origin. At examples of the biological nature of disease processes provided the framework for an evolutionary change in one time, the heliocentric theories of astronomy and the metallurgic transmutations of alchemy had their thinking. The new psychological and philosophical milieu provided the basis for an unprecedented accel­ counterparts in magical and vitalistic approaches to eration in the pace of biomedical research. It is clear human disease. Any relation between disease of humans and that of animals was not only unacceptable that the biological revolution of the last 35 years was made possible not only by technological advances and intellectually, but abhorrent theologically. Humans (and their diseases) were unique, and biology was the innovative analytical methods, but also by an intellec­ domain of those who studied animals and plants. tual emphasis on the unity of biological processes. The unification of biology and the study of human High school students are now aware that there is much disease, though begun some centuries ago, was con­ to be learned about the human condition by studying spicuously stimulated by the work of Darwin, and bacterial DNA, the chloroplasts of green leaves, or the reached its full flower in this century. For example, kinetics of enzymes in vitro.

• cancer
• cell
• mutation
• pathogenesis
• tumor

• Department of Pathology and Cell Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, USA

  Emanuel Rubin, Ivan Damjanov

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