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The Muscarinic Receptors

  • Book
  • © 1989

Overview

Editors:
  1. Joan Heller Brown

    1. University of California, San Diego, La Jolla, USA

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Part of the book series: The Receptors (REC)

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-xviii
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  2. Historical Perspectives

    1. Front Matter

      Pages 1-1
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    2. History and Basic Properties of the Muscarinic Cholinergic Receptor

      • A. S. V. Burgen
      Pages 3-27

  3. Pharmacological Properties, Purification, and Cloning of Muscarinic Receptors

    1. Front Matter

      Pages 29-29
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    2. The Binding Properties of Muscarinic Receptors

      • N. J. M. Birdsall, E. C. Hulme
      Pages 31-92

    3. Muscarinic Receptor Purification and Properties

      • Michael Schimerlik
      Pages 93-124

    4. Subtypes of Muscarinic Cholinergic Receptors

      • Barry B. Wolfe
      Pages 125-150

    5. Structural Determinants of Muscarinic Agonist Activity

      • Björn Ringdahl
      Pages 151-218

  4. Biochemical Effectors Coupled to Muscarinic Receptors

    1. Front Matter

      Pages 219-219
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    2. Muscarinic Cholinergic Receptor-Mediated Regulation of Cyclic AMP Metabolism

      • T. Kendall Harden
      Pages 221-257

    3. Muscarinic Cholinergic Receptor Regulation of Inositol Phospholipid Metabolism and Calcium Mobilization

      • Joan Heller Brown, Patrick M. McDonough
      Pages 259-307

    4. Muscarinic Receptor Regulation of Cyclic GMP and Eicosanoid Production

      • Michael McKinney, Elliott Richelson
      Pages 309-339

    5. Muscarinic Cholinergic Receptor Regulation of Ion Channels

      • R. Alan North
      Pages 341-373

  5. Regulation of Muscarinic Receptors

    1. Front Matter

      Pages 375-375
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    2. Allosteric Interactions of Muscarinic Receptors and Their Regulation by Other Membrane Proteins

      • Yoav I. Henis, Yoel Kloog, Mordechai Sokolovsky
      Pages 377-418

    3. Regulation and Development of Muscarinic Receptor Number and Function

      • Neil M. Nathanson
      Pages 419-454

  6. Future Directions

    1. Front Matter

      Pages 455-455
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    2. Future Directions

      • N. J. M. Birdsall, E. C. Hulme
      Pages 457-471

  7. Back Matter

    Pages 473-478
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Keywords

About this book

Research on muscarinic receptors is advancing at an extraordinary rate. Ten years ago, the existence of muscarinic receptor sub­ types was a logical assumption with only scattered experimen­ tal support. The discovery that pirenzepine recognized apparent heterogeneity in muscarinic binding sites infused new life into the problem of subclassifying muscarinic receptors. Simultaneous advances in molecular biology created a frenzy to clone cell sur­ face receptors. The muscarinic receptor succumbed surprisingly quickly, revealing its structure and that of at least four closely related gene products within a year. Our hope of obtaining clear evidence for muscarinic receptor subtypes was answered with a vengeance. Now a family of muscarinic receptors sits before us, asking to be understood. The bounty is as attractive to those who have not previously studied muscarinic receptors as to those who have dedicated their research careers to this subject. The goal of this book is to ensure that the new generation of research will profit from the wisdom of the past. The tools of molecular biology are well suited to the tasks of characteriz­ ing the pharmacology, function, and regulation of the distinct muscarinic receptor subtypes. However, efficient and intelligent use of these tools is not possible, unless one understands the properties of the receptor, the molecular mechanisms by which it couples to effectors, and the ways that it is regulated.

Editors and Affiliations

  • University of California, San Diego, La Jolla, USA

    Joan Heller Brown

Bibliographic Information

  • Book Title: The Muscarinic Receptors

  • Editors: Joan Heller Brown

  • Series Title: The Receptors

  • DOI: https://doi.org/10.1007/978-1-4612-4498-1

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Humana Press Inc. 1989

  • Hardcover ISBN: 978-0-89603-156-2Published: 05 September 1989

  • Softcover ISBN: 978-1-4612-8847-3Published: 22 January 2012

  • eBook ISBN: 978-1-4612-4498-1Published: 06 December 2012

  • Series ISSN: 1048-6909

  • Series E-ISSN: 2524-6488

  • Edition Number: 1

  • Number of Pages: XVIII, 478

  • Topics: Neurosciences

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