Chemical Induction of Cancer

1. Front Matter

   Pages i-xxxii

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2. Prefatory Chapter

   1. Multifactor Interaction Network of Carcinogenesis — A “Tour Guide”

      • Joseph C. Arcos, Mary F. Argus

      Pages 1-20

3. Cross-Reactions Between Carcinogens. Modification of Chemical Carcinogenesis by Noncarcinogenic Agents

   1. Front Matter

      Pages 21-21

      PDF

   2. Synergism and Antagonism Between Chemical Carcinogens

      • Martin R. Berger

      Pages 23-49

   3. Synergism in Carcinogenesis: Mathematical Approaches to its Evaluation

      • Arnold E. Reif

      Pages 51-71

   4. Inhibition of Chemical Carcinogenesis

      • Gary J. Kelloff, Charles W. Boone, Vernon E. Steele, Judith R. Fay, Caroline C. Sigman

      Pages 73-122

   5. Computerized Data Management as a Tool to Study Combination Effects in Carcinogenesis

      • Yin-tak Woo, Gregg Polansky, Joseph C. Arcos, Jeff Stokes DuBose, Mary F. Argus

      Pages 185-203

   6. Intercellular Communication: A Paradigm for the Interpretation of the Initiation/Promotion/Progression Model of Carcinogenesis

      • James E. Trosko, Chia-Cheng Chang, Burra V. Madhukar, Emmanuel Dupont

      Pages 205-225

   7. Promotion and Cocarcinogenesis

      1. Promotion and Cocarcinogenesis

         • Friedrich Marks, Michael Schwarz, Gerhard Fürstenberger

         Pages 123-124

      2. Tumor Promotion in Skin

         • Friedrich Marks, Gerhard Fürstenberger

         Pages 125-160

      3. Tumor Promotion in Liver

         • Michael Schwarz

         Pages 161-179

      4. Note on Multistage Carcinogenesis in Other Organs and <i>in Vitro</i>

         • Friedrich Marks

         Pages 180-183

      5. Note on Tumor Promoters, Cocarcinogens, and Nongenotoxic Carcinogens

         • Friedrich Marks

         Pages 183-184

4. Exogenous Factors and Endogenous Biological Parameters that Modulate Chemical Carcinogenesis

   1. Front Matter

      Pages 235-235

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   2. Immunotoxicology of Chemical Carcinogens

      • Karen A. Sullivan, John E. Salvaggio

      Pages 237-272

   3. The Effect of Diet on Tumor Induction

      1. Effect of Caloric (Energy) Restriction

         • David Kritchevsky

         Pages 273-283

      2. Modulation by Protein and Individual Amino Acids

         • Erwin J. Hawrylewicz

         Pages 284-315

      3. Modulation by Vitamins

         • Edgar Petru, Yin-tak Woo, Martin R. Berger

         Pages 316-334

      4. Modulation by Minerals

         • Maryce M. Jacobs, Roman J. Pienta

         Pages 335-356

      5. Dietary Fiber and its Effect on Cancer Incidence

         • David Kritchevsky

         Pages 357-366

In the approach to the analysis of disease, including, of course, cancer, two major thrusts may be distinguished. These may be referred to, in shorthand, as agents and processes: the causative agents (chemical, microbial, physical, environmental, and psychosocial) and the organismic processes, initiated and furthered by the agents, culminating in observable pathology (at the macromolecular, cytological, histological, organ function, locomotor, and behavioral levels). The past 25 years, since the appearance of the first volume of the predecessor series (1) authored by the Editors of this present volume, have seen an impressive number of studies on chemicals (and other agents) as etiologic factors in the induction of cancer. The major emphasis has been on the discovery of many chemical carcinogens of widely different structures, their metabolism by various tissues and cells, and, in turn, their molecular-biochemical effects on the cells. This rapidly expanded body of information, as effectively covered in the predecessor volumes, is an excellent entree to the second half of the overall problem of chemical carcinogenesis, the processes. The active agents trigger a large array of molecular-biochemical alterations to which the target cells, target tissues, and target organisms respond in many select and common ways. This second major aspect of the induction of cancer by chemicals (and by other agents)- the sequence of cellular and tissue changes clearly relevant to cancer-remains the challenge for the future.

• Alanin
• Amino acid
• Calcium
• Colon
• DNA
• RNA
• Vitamin D
• aging
• angiogenesis
• apoptosis
• classification
• gene expression
• metabolism
• proteins
• transcription

• U.S. Environmental Protection Agency, Washington, USA

  Joseph C. Arcos, Mary F. Argus, Yin-tak Woo

• Tulane University School of Medicine, New Orleans, USA

  Joseph C. Arcos, Mary F. Argus

Policies and ethics