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Experimental Malignant Hyperthermia

  • Book
  • © 1988

Overview

Editors:
  1. Charles H. Williams

    1. Regional Academic Health Center at El Paso Department of Surgery School of Medicine, Texas Tech University Health Sciences Center, El Paso, USA

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Heat Production in Malignant Hyperthermia Susceptible Muscle

    • Charles H. Williams
    Pages 1-6

  3. Plasma Catecholamines During Malignant Hyperthermia

    • Charles H. Williams, Susan E. Dozier, Charles W. Gehrke, Klaus O. Gerhardt, Joseph K. Wong
    Pages 7-19

  4. Measurement of Biogenic Amines by HPLC-ECD: ECD as a Diagnostic Tool for Malignant Hyperthermia

    • Klaus O. Gerhardt, Charles W. Gehrke, Charles H. Williams, Joseph K. Wong
    Pages 20-29

  5. Hemodynamics in Malignant Hyperthermia Susceptible Pigs During Malignant Hyperthermia

    • Charles H. Williams, Susan E. Dozier, Mary Farias
    Pages 30-45

  6. Plasma Levels of T4, T3 and rT3 During Malignant Hyperthermia

    • R. R. Anderson, M. A. Akasha, D. A. Nixon, Charles H. Williams
    Pages 46-58

  7. Malignant Hyperthermia and the Sarcoplasmic Reticulum Membrane: A Review

    • Mariam A. Marvasti, Charles H. Williams
    Pages 59-77

  8. In Vitro Studies of Drugs Affecting Malignant Hyperthermia Muscle

    • Wilfried K. Ilias, Charles H. Williams, Susan E. Dozier, Robert T. Fulfer
    Pages 78-89

  9. The Role of the Horse in Studies Relative to Malignant Hyperthermia

    • Charles E. Short, Nora S. Matthews
    Pages 90-99

  10. Horses and Ponies as Animal Models for Malignant Hyperthermia

    • Susan V. Hildebrand
    Pages 100-117

  11. Malignant Hyperthermia in the Dog: Laboratory Investigations

    • Peter H. Cribb
    Pages 118-120

  12. Laboratory Methods for Malignant Hyperthermia Diagnosis

    • Jeffrey E. Fletcher, Henry Rosenberg
    Pages 121-140

  13. Malignant Hyperthermia: A Review

    • Michael Denborough
    Pages 141-146

  14. Malignant Hyperthermia: Pre- and Post-Dantrolene

    • Mark G. Zukaitis, George P. Hoech Jr., John D. Robinson
    Pages 147-153

  15. The Role of the Sympathetic Nervous System in Patients Susceptible to Malignant Hyperthermia

    • J. Hilary Green, F. Richard Ellis, P. Jane Halsall, Iain T. Campbell
    Pages 155-160

  16. Back Matter

    Pages 161-166
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Keywords

About this book

Malignant hyperthermia is a genetic disease that causes an extremely high body temperature. The syndrome is triggered by depolarizing muscle relaxants and halogenated gaseous anesthetics, such as halothane. The purpose of the book is to present the latest experimental work and important conclusions to anesthesiologists, surgeons, certified registered nurse anesthesists, operating nurses, cardiovascular and temperature oriented physiologists, basic research scientists interested in heat production in muscle, animal scientists, primarily swine physiologists, and finally, muscle biology scientists. The results are based on sixteen years of experimental investigations with a malignant hyperthermia susceptible pig colony. Consequently, the data and conclusions are more concrete than the clinical data from human patients. The first five chapters present fresh material relating to the detailed biochemical mechanism of heat production during malignant hyperthermia. Subsequent chapters present recent data on malignant hyperthermia in horses and dogs; these additional animal models provide useful material for future studies of malignant hyperthermia pathophysiology. Later sections summarize the laboratory methods currently used for diagnosing malignant hyperthermia in human patients and present valuable data on malignant hyperthermia in the greater Kansas city area over a twenty year period.

Editors and Affiliations

  • Regional Academic Health Center at El Paso Department of Surgery School of Medicine, Texas Tech University Health Sciences Center, El Paso, USA

    Charles H. Williams

Bibliographic Information

  • Book Title: Experimental Malignant Hyperthermia

  • Editors: Charles H. Williams

  • DOI: https://doi.org/10.1007/978-1-4612-3738-9

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag New York Inc. 1988

  • Softcover ISBN: 978-1-4612-8327-0Published: 22 September 2011

  • eBook ISBN: 978-1-4612-3738-9Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XIII, 166

  • Topics: Oncology

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