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Molecular Biology of Chromosome Function

  • Book
  • © 1989

Overview

Editors:
  1. Kenneth W. Adolph

    1. Department of Biochemistry, University of Minnesota Medical School, Minneapolis, USA

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-xiii
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  2. DNA Replication and Recombination

    1. Front Matter

      Pages 1-2
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    2. Enzymes of DNA Precursor Synthesis and the Control of DNA Replication

      • Christopher K. Mathews
      Pages 3-20

    3. Replication Fork Propagation in Escherichia coli

      • Russell J. DiGate, Kenneth J. Marians
      Pages 21-42

    4. The Role of RecA Protein in Homologous Genetic Recombination

      • Michael M. Cox
      Pages 43-70

    5. The SV40 Large Tumor Antigen

      • Arnold J. Levine
      Pages 71-96

    6. Replication of the Human Immunodeficiency Virus

      • Charles S. McHenry
      Pages 97-129

  3. Gene Transcription

    1. Front Matter

      Pages 131-132
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    2. Escherichia coli Repressor Proteins

      • Kyle L. Wick, Kathleen S. Matthews
      Pages 133-156

    3. Eukaryotic RNA Polymerases

      • Ekkehard K. F. Bautz, Gabriele Petersen
      Pages 157-179

    4. Applications of Monoclonal Antibodies to the Study of Eukaryotic RNA Polymerases

      • Nancy E. Thompson, Richard R. Burgess
      Pages 180-206

    5. RNA Polymerase III and Transcription of 5S Ribosomal DNA

      • John J. Furth
      Pages 207-223

    6. Structure and Function of Rho Factor and Its Role in Transcription Termination

      • Alicia J. Dombroski, Terry Platt
      Pages 224-242

    7. The Mechanism and Control of Pre-mRNA Splicing

      • Jonathan C. S. Noble, James L. Manley
      Pages 243-261

    8. Ribonucleoproteins and the Structure of Nascent Transcripts

      • Stanley F. Barnett, Stephanie J. Northington, Wallace M. LeStourgeon
      Pages 262-279

  4. Chromosome Organization

    1. Front Matter

      Pages 281-282
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    2. Spatial Distribution of Chromosomes in Human Mitotic Cells

      • Kenneth W. Adolph
      Pages 283-301

    3. Structure/Function Relationships in the Bacteriophage T4 Single-Stranded DNA-Binding Protein

      • Yousif Shamoo, Kathleen M. Keating, Kenneth R. Williams, William H. Konigsberg
      Pages 302-322

    4. Crystallographic Studies of Two Proteins that Bind Single-Stranded DNA

      • Alexander McPherson
      Pages 323-346

    5. Histone and Nucleosome Function in Yeast

      • Michael Grunstein, Min Han, Ung-Jin Kim, Tillman Schuster, Paul Kayne
      Pages 347-365
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Keywords

About this book

Chromosomes have structure, determined by the interactions of proteins with DNA, and chromosomes have functions, in particular, replication of DNA and transcription of messenger RNA. Chromosome structure and function are not separate topics, since chromosome organization pro­ foundly influences the activity of the genome in replication and transcrip­ tion. This is especially clear for higher cells, including human cells, in which chromatin fibers are created by the binding of histone proteins to the DNA, and folding of the fibers produces mitotic chromosomes and interphase nuclei. The intricate organization of DNA in higher cells is now recognized as being closely involved with genome activity. Many fundamental results have originated from studies of bacterial and viral systems, which have been systems of choice because of their less complex life cycles. The processes of replication and transcription show differences between the higher and simpler systems (e. g. , different enzymes and protein factors are involved). But the parallels are as striking as the differences in detail. Even for bacteria and viruses, a full understanding of these processes will require integrating the results of molecular biology with those of structural biology and cell biology. Three important subjects are covered in this volume: DNA replication and recombination, gene transcription, and chromosome organization. The sections dealing with replication and transcription examine recent results obtained by applying the techniques of molecular biology and biochemistry. Eukaryotic, prokaryotic, and viral systems are discussed.

Editors and Affiliations

  • Department of Biochemistry, University of Minnesota Medical School, Minneapolis, USA

    Kenneth W. Adolph

Bibliographic Information

  • Book Title: Molecular Biology of Chromosome Function

  • Editors: Kenneth W. Adolph

  • DOI: https://doi.org/10.1007/978-1-4612-3652-8

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag New York Inc. 1989

  • Softcover ISBN: 978-1-4612-8192-4Published: 22 September 2011

  • eBook ISBN: 978-1-4612-3652-8Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XIII, 431

  • Topics: Cell Biology, Biological and Medical Physics, Biophysics

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