Pathobiology of the Human Atherosclerotic Plaque

1. Front Matter

   Pages i-xxxi

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2. Introduction

   1. Front Matter

      Pages xxxi-xxxi

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   2. Questions About the Natural History of Human Atherosclerosis

      • Henry C. McGill Jr

      Pages 1-11

3. Cellular Contents

   1. Front Matter

      Pages 1-1

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   2. Arterial Endothelial Structure and Permeability as It Relates to Susceptibility to Atherogenesis

      • Ross G. Gerrity

      Pages 13-45

   3. Second Messengers in Human Vascular Endothelial Cells: Regulation of Endothelial Monolayer Formation and Repair

      • Vladimir N. Smirnov, Alexander S. Antonov, Matvey E. Lukashev, Yuri A. Romanov, J. Frederic Cornhill, Ross G. Gerrity

      Pages 47-62

   4. Cytoskeletal Characterization of Smooth Muscle Cells of Human and Experimental Atherosclerotic Plaques

      • G. Gabbiani

      Pages 63-68

   5. Phenotypic Changes in Smooth Muscle Cells of Human Atherosclerotic Plaques

      • G. R. Campbell, J. H. Campbell, A. H. Ang, I. L. Campbell, S. Horrigan, J. A. Manderson et al.

      Pages 69-92

   6. Changes in the Cells of Atherosclerotic Lesions as Advanced Lesions Evolve in Coronary Arteries of Children and Young Adults

      • H. C. Stary

      Pages 93-106

   7. Inflammatory Components of the Human Atherosclerotic Plaque

      • Colin J. Schwartz, Eugene A. Sprague, Anthony J. Valente, Jim L. Kelley, Ellen H. Edwards, C. Alan Suenram

      Pages 107-120

   8. The Role of Macrophages in Human Atherosclerosis

      • Malcolm J. Mitchinson, Keri L. H. Carpenter, Richard Y. Ball

      Pages 121-128

   9. Recent Observations on Human Atherosclerotic Lesions, and their Possible Significance

      • M. Daria Haust

      Pages 129-144

4. Tissue Organization and Architecture

   1. Front Matter

      Pages 3-3

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   2. Intimal Lipids and Associated Changes in Intimal Composition

      • Elspeth B. Smith

      Pages 145-153

   3. Evolution of the Atherosclerotic Plaque—A Physico—chemical Approach to Lipid Deposition

      • Donald M. Small

      Pages 155-166

   4. Modification of Collagen and Elastin in the Human Atherosclerotic Plaque

      • William D. Wagner

      Pages 167-188

   5. Nature and Importance of Proteoglycans in the Atherosclerotic Plaque

      • G. S. Berenson, B. Radhakrishnamurthy, S. R. Sinivasan, P. Vijayagopal, E. R. Dalferes Jr.

      Pages 189-208

   6. Biochemical and Immunological Evidence for the Presence of Lipoprotein-Antilipoprotein Immune Complexes in Human Atherosclerotic Plaques

      • William Hollander, Antonio Lazzari, Carl Franzblau

      Pages 209-234

   7. Mechanisms of Calcification in Atherosclerosis

      • H. C. Anderson, D. H. McGregor, A. Tanimura

      Pages 235-249

   8. Characterization of Nucleating Proteolipids from Calcified and Non-Calcified Atherosclerotic Lesions

      • Rosemarie Romeo, Joan M. Augustyn, Gretchen Mandel, Assaad S. Daoud

      Pages 251-262

Seymour Glagov The last meeting, devoted exclusively to an examination of the atherosclerotic plaque, took place in Chicago 25 years ago under the joint auspices of the Council on Arteriosclerosis of the American Heart Association and the Chicago Heart Association. The proceedings were published subsequently in a volume entitled "Evolution of the Atherosclerotic Plaque", edited by Richard J. Jones (1). Both experimental and human lesions were considered and several provocative new approaches to the disorder were discussed. The electron microscope was being applied systematically to the study of blood vessels at that time, so that details of the infrastructure and cellular composition of the artery wall and of atherosclerotic lesions were presented in some detail. There was, as one result of these explorations, considerable discussion of morphologic evidence suggesting that the principal cell involved in the atherogenic process was neither the fibroblast nor the macrophage, as had been supposed, but the smooth muscle cell. In particular, the findings indicated that this cell could incorporate lipid and become a foam cell.

• Artherienverkalkung
• Bypass
• Lipoprotein
• Pathologie
• artery
• atherosclerosis
• cell
• heart
• pathobiology
• pathogenesis
• pathology
• perception
• platelet
• tissue
• ultrasound

• The University of Chicago Hospital, Chicago, USA

  Seymour Glagov

• Department of Pathology, Louisiana State University, New Orleans, USA

  William P. Newman

• Colestech Corporation, Hayward, USA

  Sheldon A. Schaffer

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