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Aplastic Anemia and Other Bone Marrow Failure Syndromes

  • Book
  • © 1990

Overview

Editors:
  1. Nasrollah T. Shahidi

    1. Department of Pediatrics, University of Wisconsin-Madison, Madison, USA

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-xvii
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  2. Bone Marrow and Hemopoiesis

    • Mehdi Tavassoli
    Pages 1-24

  3. Acquired Aplastic Anemia: Classification and Etiologic Considerations

    • N. T. Shahidi
    Pages 25-37

  4. Constitutional Aplastic Anemia

    • Blanche P. Alter
    Pages 38-50

  5. Cytogenetics in Constitutional Aplastic Anemia

    • Arleen D. Auerbach
    Pages 51-62

  6. Cellular Interactions in the Suppression of Hematopoiesis

    • F. Roy MacKintosh, Jean C. Schulman, Esmail D. Zanjani
    Pages 63-81

  7. Flow Cytofluorometric Analysis of Patient Mononuclear Cells and Clinical Response to Antithymocyte Globulin

    • Beverly Torok-Storb, Gretchen G. Johnson
    Pages 82-87

  8. Prospects for the Treatment of Aplastic Anemia

    • Neal S. Young
    Pages 88-95

  9. Treatment of Severe Aplastic Anemia: A 12-Year Follow-Up of Patients after Bone Marrow Transplantation or after Therapy with Antilymphocyte Globulin

    • B. Speck, A. Tichelli, A. Gratwohl, C. Nissen
    Pages 96-103

  10. Long-Term Comparison of Immunosuppressive Therapy with Antithymocyte Globulin to Bone Marrow Transplantation in Aplastic Anemia

    • Kristine Doney, Kenneth Kopecky, Rainer Storb, C. Dean Buckner, Jack Singer, Claudio Anasetti et al.
    Pages 104-114

  11. Treatment of Severe Aplastic Anemia (SAA) with Bone Marrow Transplantation (BMT) or Immunosuppression: A Report of the EBMT SAA Working Party

    • A. Bacigalupo, J. Hows, A. Wursh, C. Nissen, E. Gluckman, A. Devergie et al.
    Pages 115-120

  12. Treatment of Aplastic Anemia: Bone Marrow Transplantation, Immunomodulatory Therapy, and Hematopoietic Growth Factors

    • Richard Champlin
    Pages 121-133

  13. Bone Marrow Transplantation for Fanconi Anemia

    • E. Gluckman
    Pages 134-144

  14. The Use of Etiocholanolone and Antithymus Globulin to Treat Aplastic Anemia: An Uncontrolled Comparative Study

    • Frank H. Gardner, Harinder S. Juneja
    Pages 145-154

  15. Treatment of Acquired Aplastic Anemia with Cyclosporine and Androgens

    • N. T. Shahidi, W. Wang, S. Shurin, J. Finlay, P. Sondel, P. Dinndorf
    Pages 155-165

  16. Congenital Hypoplastic Anemia (Diamond — Blackfan Anemia)

    • Bertil E. Glader
    Pages 166-178

  17. Pure Red Cell Aplasia

    • Emmanuel N. Dessypris
    Pages 179-198

  18. The Preleukemic Syndrome (Hematopoietic Dysplasia)

    • Grover C. Bagby Jr.
    Pages 199-223

  19. Summary and Conclusions

    • David G. Nathan
    Pages 224-229

  20. Back Matter

    Pages 231-236
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Keywords

About this book

During the past decade, there have been numerous direct and indirect scientific contributions to both the etiology and therapy of aplastic anemia and related bone marrow failure syndromes. Clinical observations, such as autologous bone marrow recovery after conditioning with immunosup­ pressive agents for bone marrow transplantation; failure to achieve en­ graftment in some identical twins without prior immunosuppressive ther­ apy; and hematologic response to immunosuppressive agents, have led to the concept of immune-mediated etiology of acquired aplastic anemia. Such a concept was further strengthened by laboratory findings, implicat­ ing the role of activated cytotoxic T lymphocytes and abnormal produc­ tion of inhibitory lymphokines. The immunologic mechanisms may also apply to the idiosyncratic bone marrow aplasias associated with drugs, toxic chemicals, and viruses. These agents may alter normal cellular recog­ nition sites by interacting with cellular components and result in loss of self tolerance. Immunologic mechanisms have long been advocated in many other organ failures, and the hemopoietic organ is no exception. It is of interest that parallel clinical and laboratory investigations in juvenile diabetes mellitus type I and in rodent models of this disease have yielded results compatible with the same pathogenic mechanisms. The infiltration of pancreatic islets by activated T lymphocytes, functional and morphological alterations of islet cells upon incubation with lymphokines such as gamma interferon and tumor necrosis factor, and clinical response to cyclosporine are a few examples.

Editors and Affiliations

  • Department of Pediatrics, University of Wisconsin-Madison, Madison, USA

    Nasrollah T. Shahidi

Bibliographic Information

  • Book Title: Aplastic Anemia and Other Bone Marrow Failure Syndromes

  • Editors: Nasrollah T. Shahidi

  • DOI: https://doi.org/10.1007/978-1-4612-3254-4

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Inc. 1990

  • Softcover ISBN: 978-1-4612-7935-8Published: 27 September 2011

  • eBook ISBN: 978-1-4612-3254-4Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XVII, 236

  • Topics: Hematology, Oncology, Pediatrics, Allergology, Immunology, Cell Biology

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