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Leukocyte Adhesion Molecules

Proceedings of the First International Conference on: "Structure, Function and Regulation of Molecules Involved in Leukocyte Adhesion", Held in Titisee, West Germany, September 28 - October 2, 1988

  • Conference proceedings
  • © 1990

Overview

Editors:
  1. Timothy A. Springer

    1. Center for Blood Research, Harvard Medical School, Boston, USA

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  2. Donald C. Anderson

    1. Pediatrics, Microbiology and Immunology, Head, Leukocyte Biology Section, Baylor College of Medicine and Texas Children’s Hospital, Houston, USA

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  3. Robert Rothlein

    1. Department of Immunology, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, USA

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  4. Alan S. Rosenthal

    1. Research & Development, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, USA

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Table of contents (23 papers)

  1. Front Matter

    Pages i-xv
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  2. Introduction

    1. Introduction

      • Alan S. Rosenthal
      Pages 1-3

  3. Structure and Function of the Integrin Family

    1. Front Matter

      Pages 5-5
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    2. Leukocyte Integrins

      • Takashi K. Kishimoto, Richard S. Larson, Angel L. Corbi, Michael L. Dustin, Donald E. Staunton, Timothy A. Springer
      Pages 7-43

    3. Structure and Functions for the Adhesion Receptors VLA-2 and VLA-4: Comparisons to other Members of the Integrin Superfamily

      • Martin E. Hemler, Yoshikazu Takada, Mariano Elices, Carol Crouse
      Pages 44-57

    4. Fibronectin Receptor Expression on Thymocytes

      • Michael D. Pierschbacher, Pina M. Cardarelli
      Pages 58-71

    5. Mechanism Regulating Recruitment of CD11b/CD18 to the Cell Surface is Distinct From That Which Induces Adhesion in Homotypic Neutrophil Aggregation

      • Jill P. Buyon, Mark R. Philips, Steven B. Abramson, Seth G. Slade, Gerald Weissmann, Robert Winchester
      Pages 72-83

  4. Adhesion in Disease and Therapy

    1. Front Matter

      Pages 85-85
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    2. Mechanisms of Neutrophil Emigration

      • C. M. Doerschuk, R. K. Winn, J. M. Harlan
      Pages 87-94

    3. Leukocyte Adhesion Deficiency as a Model for the Study of the Functional Role of LFA-1

      • A. Fischer, B. Lisowska-Grospierre, F. Mazerolles, F. Le Deist, N. Perez, M. T. Dimanche-Boitrel et al.
      Pages 95-100

    4. Role of Cellular Adhesion in Inflammatory Cutaneous Disorders

      • Gunhild Lange Vejlsgaard, Nils Lauge Hansen, Elisabeth Ralfkiaer, Robert Rothlein
      Pages 101-105

    5. Characterization of a New Mobilizable Mac-1 (CD11b/CD18) Pool That Co-Localizes with Gelatinase in Human Neutrophils

      • Douglas H. Jones, Frank C. Schmalstieg, Hal K. Hawkins, Bean L. Burr, Helen E. Rudloff, Sharon Krater et al.
      Pages 106-124

    6. Anti-Inflammatory Properties of Monoclonal Anti-Mo1 (CD11b/CD18) Antibodies In Vitro and In Vivo

      • Robert F. Todd III, Paul J. Simpson, Benedict R. Lucchesi
      Pages 125-137

    7. CDw18 Dependent Adhesion of Leukocytes to Endothelium and Its Relevance for Cardiac Reperfusion

      • Elke Seewaldt-Becker, Robert Rothlein, JĂĽrgen W. Dämmgen
      Pages 138-148

    8. Role of Anti-Adhesion Monoclonal Antibodies in Rabbit Lung Inflammation

      • Randall W. Barton, Robert Rothlein, John Ksiazek, Charles Kennedy
      Pages 149-155

  5. Myeloid Cell Adhesion

    1. Front Matter

      Pages 157-157
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    2. The Role of LFA-1 and Related Antigens in Adhesion-Mediated Functions of Human Monocytes

      • Carl G. Figdor, Anje Te Velde, Jan E. De Vries
      Pages 159-169

    3. Role of ICAM-1 in the Adherence of Human Neutrophils to Human Endothelial Cells In Vitro

      • C. Wayne Smith, Steven D. Marlin, Robert Rothlein, Michael B. Lawrence, Larry V. McIntire, Donald C. Anderson
      Pages 170-189

    4. Specificity and Regulation of CD18-Dependent Adhesions

      • Samuel D. Wright, Siu Kong Lo, Patricia A. Detmers
      Pages 190-207

    5. CD18 Dependence of Primate Eosinophil Adherence In Vitro

      • Craig D. Wegner, C. Wayne Smith, Robert Rothlein
      Pages 208-214
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Keywords

About this book

Leukocyte adhesion molecules promise to be highly effective as antigens in the antibody-directed leucocyte elimination treatment prior to grafting or in cases of acute and chronic inflammatory disease. This comprehensive review of contemporary research provides thorough discussions of the structure of these molecules, their in vitro function, and the role that they play in vivo as evidenced by results shown in inflammatory models where antibodies against these molecules are given to inhibit their function. The blend of basic science and clinical applications provides clear evidence of the biological relevance of cell-cell interactions and the many potential clinical dividends afforded by understanding the molecular basis of cell adhesion.

Editors and Affiliations

  • Center for Blood Research, Harvard Medical School, Boston, USA

    Timothy A. Springer

  • Pediatrics, Microbiology and Immunology, Head, Leukocyte Biology Section, Baylor College of Medicine and Texas Children’s Hospital, Houston, USA

    Donald C. Anderson

  • Department of Immunology, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, USA

    Robert Rothlein

  • Research & Development, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, USA

    Alan S. Rosenthal

Bibliographic Information

  • Book Title: Leukocyte Adhesion Molecules

  • Book Subtitle: Proceedings of the First International Conference on: "Structure, Function and Regulation of Molecules Involved in Leukocyte Adhesion", Held in Titisee, West Germany, September 28 - October 2, 1988

  • Editors: Timothy A. Springer, Donald C. Anderson, Robert Rothlein, Alan S. Rosenthal

  • DOI: https://doi.org/10.1007/978-1-4612-3234-6

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag New York Inc. 1990

  • Softcover ISBN: 978-1-4612-7927-3Published: 13 October 2011

  • eBook ISBN: 978-1-4612-3234-6Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XV, 287

  • Topics: Life Sciences, general, Oncology, Anthropology, Immunology

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