Autoimmunity and the Pathogenesis of Diabetes

1. Front Matter

   Pages i-xii

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2. The Autoimmune Hypothesis of Insulin-Dependent Diabetes: 1965 to the Present

   • Thomas Mandrup-Poulsen, Jørn Nerup

   Pages 1-28

3. Immunogenetics and the Pathogenesis of Insulin-Dependent Diabetes Mellitus

   • Pablo Rubinstein

   Pages 29-55

4. Association of Insulin-Dependent Diabetes Mellitus and Other Autoimmune Diseases

   • Fredda Ginsberg-Fellner

   Pages 56-67

5. The Humoral Anti-Islet Immune Response: Cytoplasmic Islet-Cell Antibodies: Technical Aspects and Clinical Applications

   • Helga Gleichmann, Gian Franco Bottazzo

   Pages 68-86

6. The Humoral Anti-Islet Response: Biochemical Characterization

   • Heike Bärmeier, Michael Christie, Betsy Herold, Kevan Herold, Åke Lernmark

   Pages 87-104

7. The Humoral Anti-Islet Immune Response: Immunochemical Studies of Glycoconjugate Antigens

   • R. C. Nayak, G. S. Eisenbarth

   Pages 105-146

8. Insulin Autoantibodies

   • Jerry P. Palmer

   Pages 147-164

9. Cell-Mediated Anti-Islet—Cell Immune Response: Clinical Experience and Lessons from Animal Models

   • Robert C. McEvoy, Nancy M. Thomas

   Pages 165-183

10. The Pathogenesis of Immunologically Mediated Diabetes

    • Yi Wang, Liming Hao, Kevin J. Lafferty

    Pages 184-205

11. Viral Pathogenesis of Insulin-Dependent Diabetes Mellitus

    • Ji-Won Yoon

    Pages 206-255

12. Immune Intervention in Diabetes: State of the Art and Future Directions

    • J. Dupré, C. R. Stiller

    Pages 256-281

13. Back Matter

    Pages 283-296

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It has been a challenge for us to edit this volume of Endocrinology and Metabo­ lism: Progress in Research and Clinical Practice. The topic of the pathogenesis of insulin-dependent, type I diabetes mellitus is particularly appropriate for this series, since advances in this area have been made, to a large extent, by applying state-of-the-art laboratory techniques to clinical samples. Over the last several years, a number of lines of evidence have been gathered, suggesting that classic type I diabetes mellitus results from the autoimmune des­ truction of pancreatic beta-cells in genetically susceptible individuals. This hypothesis is particularly appealing because it offers a rational approach to the prevention of diabetes by immunosuppression. We have tried to present a balanced, authoritative summary of the information currently available to support the autoimmune hypothesis for the pathogenesis of human type I diabetes, to place this information in historical perspective, to include relevant information from animal models of type I diabetes in which more invasive experimentation is ethical, and, finally, to update the reader on the current status of attempts to intervene in the progression of diabetes with immunosuppressive drugs. New York, New York Fredda Ginsberg-Fellner Robert C. McEvoy Contents Preface.. . . .. .. .. . . . . . . . . . . . . ... . . . . . . . . . . . .. . . . . . . .. . . . . v Contributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Xl . . . . . . . . . . . . . 1. The Autoimmune Hypothesis of Insulin-Dependent Diabetes: 1965 to the Present . . . . . . . . . . . . ..................... . . . . . .

• Antigen
• Diabetes
• Diabetes mellitus
• Insulin
• Pancreas
• Pancreatic Islets
• Termination
• autoimmune disease
• autoimmunity
• genetics
• immunosuppression
• immunotherapy
• infection
• pathogenesis
• virus
• metabolic disease

• Division of Pediatric Endocrinology and Metabolism, Mount Sinai School of Medicine, New York, USA

  Fredda Ginsberg-Fellner

• Mount Sinai School of Medicine, New York, USA

  Robert C. McEvoy

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