Genetic Models of Immune and Inflammatory Diseases

1. Front Matter

   Pages i-xvi

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2. Autoimmunity

   1. Front Matter

      Pages 1-1

      PDF

   2. Intensification of Diabetes in B7-1 Transgenic Mice

      • Charles A. Janeway Jr., Florence Susan Wong, Sylvie Guerder, Eva-Pia Reich, Irene Visintin, Richard A. Flavell

      Pages 3-15

   3. A Transgenic Window on Self-Reactive T Lymphocytes

      • Jacques F. A. P. Miller, William R. Heath, Janette Allison

      Pages 16-21

   4. Induction and Breaking of Peripheral Tolerance

      • Günter J. Hämmerling, Judith Alferink, Iris Ferber, Andreas Limmer, Bernd Arnold

      Pages 22-28

   5. T-Cell Development and Tolerance in Virus-Specific Transgenic Models

      • Pamela S. Ohashi

      Pages 29-43

   6. Inflammatory Disease in HLA-B27 Transgenic Rats

      • Joel D. Taurog, Robert E. Hammer

      Pages 44-50

3. Autoimmunity, Infections

   1. Front Matter

      Pages 69-69

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   2. The Role of CD40 Ligand in Regulation of Immune Response

      • Iqbal S. Grewal, Jianchao Xu, Richard A. Flavell

      Pages 53-68

   3. Adventures in Antigen Presentation

      • David Lo

      Pages 69-81

   4. The Effect of MHC Encoding Transgenes on IDDM in NOD Mice

      • Ruby Quartey Papafio, Don Healey, Lorraine O’reilly, Patricia Hutchings, Sue Day, Anne Cooke

      Pages 82-88

   5. The Immunology of Leishmania Major Infection in Mice

      • Richard M. Locksley

      Pages 89-97

4. Cytokines, Co-Stimulators, Tumor Immunity

   1. Front Matter

      Pages 117-117

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   2. The Regulatory Functions of Co-Stimulators Revealed in Transgenic Mice

      • Michael P. Sethna, Luk Van Parijs, Arlene H. Sharpe, Gordon J. Freeman, Abul K. Abbas

      Pages 101-106

   3. B7-Deficient Mice Reveal an Alternative Functional CTLA-4 Counterreceptor

      • Frank Borriello, Elizabeth A. Tivol, Gordon J. Freeman, Arlene H. Sharpe

      Pages 107-120

   4. Cytokine Transgenic Mice and Autoimmunity

      • Myung-Shik Lee, Nora Sarvetnick

      Pages 121-128

   5. Gaining Insights into the Ontogeny and Activation of T Cells Through the Use of Gene-Targeted Mutant Mice

      • Tak W. Mak

      Pages 129-137

   6. B7-Mediated Co-Stimulation of T Cells: CTLA-4 Can Deliver Inhibitory Signals

      • Matthew Krummel, James P. Allison

      Pages 138-146

5. Cytokine Deletions

   1. Front Matter

      Pages 147-147

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   2. Lymphoid Organogenesis and Inflammation Are Mediated by Lymphotoxin

      • Alexander Kratz, Donna M. Barten, Antonio Campos-Neto, Nancy H. Ruddle

      Pages 149-153

This book contains the proceedings of the Serono Symposia USA interna­ tional symposium on Genetic Models of Immune and Inflammatory Dis­ eases held on October 20 to 23, 1994, in Savannah, Georgia. The advent of methods for introducing genes into the germlines of mice, and for targeted disruption of particular genes by homologous recombination, has provided scientists in many disciplines with an extraordinarily powerful set of analyti­ cal tools. Some of the most informative applications of transgenic and gene knockout technology have been in studies of lymphocyte development and activation. The goal of this symposium was to bring together investigators using these genetic approaches for analyzing the immune system, with a view to defining common themes and novel directions. Transgenic mice have a wide variety of important applications in immu­ nology. Defined proteins can be expressed in selected tissues throughout development, thus acquiring the essential characteristic of "self" antigens. Such models have been used to study how immune responses to these artificially created "self" antigens are controlled. Antigen receptors of lym­ phocytes have been expressed as transgenes, and because lymphocytes are endowed with the unique property of allelic exclusion, such transgenic mice become essentially monospecific. Immunomodulatory agents have been expressed in defined tissues or throughout the body, providing tools for studying the functional consequences of dysregulated expression of biologi­ cal response modifiers.

• Antigen
• antigen presentation
• autoimmunity
• cytokine
• cytokines
• diseases
• infection
• infections
• interferon
• lymphocytes
• regulation
• tumor

• Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA

  Abul K. Abbas

• Section of Immunobiology, Yale University School of Medicine, New Haven, USA

  Richard A. Flavell

Policies and ethics