Hormonal Carcinogenesis III

1. Front Matter

   Pages i-xliii

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2. Symposium Address

   1. Symposium Address

      • Gerald C. Mueller

      Pages 1-22

3. State of the Art Lectures

   1. Front Matter

      Pages 23-23

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   2. The Numbers Game with Estrogen Receptors and Growth Regulation

      • Jack Gorski, Tae-Yon Chun, Douglas Wendell

      Pages 25-36

   3. Expression Genetics of Hormone Dependent Human Tumors

      • Arthur B. Pardee, Heide L. Ford, Debajit K. Biswas, Katherine J. Martin, Ruth Sager

      Pages 37-43

   4. New Directions in Epidemiologic Studies of Hormonally-related Cancers

      • Janet R. Daling, Kathleen E. Malone, Elaine A. Ostrander, Peggy L. Porter

      Pages 44-58

4. Epidemiology: Breast and Prostate Cancer

   1. Front Matter

      Pages 59-59

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   2. Estrogen Causes Breast Cancer: Increasing Duration of Use of Postmenopausal Hormones Increases the Risk of Breast Cancer

      • Graham A. Colditz

      Pages 61-69

   3. Frequency of BRCA2 Mutations in Women with Early Onset Breast Cancer Drawn from a Population-Based Study

      • Kathleen E. Malone, Janet R. Daling, Nicola M. Suter, Kara Cushing, Thora Jonnasdottir, Elaine A. Ostrander

      Pages 70-86

   4. Prostate Cancer, Androgens, and Estrogens

      • Janet L. Stanford

      Pages 87-96

5. Molecular Genetics of Hormonal Cancers

   1. Front Matter

      Pages 97-97

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   2. Introduction

      • Frederic M. Waldman

      Pages 99-102

   3. Genome Scanning and Tissue Microarrays for the Analysis of Molecular Mechanisms Underlying Hormone Therapy Failure in Prostate Cancer

      • Lukas Bubendorf, Olli-P. Kallioniemi

      Pages 103-112

   4. Serial Analysis of Gene Expression in Breast Cancer Cells

      • C. Marcelo Aldaz, Andrzej Bednarek, April Charpentier, Michael MacLeod, Kathleen Hawkins, Kendra Laflin

      Pages 113-123

   5. The Effects of Triphenylethylene Antiestrogens on Parameters of Multistage Hepatocarcinogenesis in the Rat

      • Yvonne P. Dragan, Emile Nuwaysir, Linda Sargent, Dong-Hui Li, V. Craig Jordan, Henry C. Pitot

      Pages 124-135

6. Estrogen Receptor Interactions

   1. Front Matter

      Pages 137-137

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   2. Introduction

      • Elwood V. Jensen

      Pages 139-143

   3. Estrogen Receptor-ß: An Important Player in Estrogen Action

      • Jan-Åke Gustafsson

      Pages 144-148

   4. Estrogen Receptor-mediated Genomic Instability in the Syrian Hamster Kidney: A Critical Event in Hormonal Oncogenesis

      • Jonathan J. Li, S. John Weroha, Marilyn Cansler, Sara Antonia Li

      Pages 149-157

7. Estrogen/Progesterone-Breast Cancer

   1. Front Matter

      Pages 159-159

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Since our previous symposium in 1995, the pace of research in hormones and cancer has accelerated. Progress in our understanding of hormonal carcinogenic processes has been a direct result of the advances made in cell biology, endocrinology, and carcinogenesis at the molecular level. The newer fields of molecular genetics and cytogenetics already have and are expected to continue to playa major role in furthering our understanding of the cellular and molecular events in hormonal carcinogenesis. It has become increasingly clear that the risk of naturally occurring sex hormones in carcinogenic processes, both in human and in animal models, requires only minute quantities of hormones, at both the serum and tissue levels. Moreover, hormone target tissues for neoplastic transformation, perhaps with the exception of the liver, generally have relatively modest ability to metabolize sex hormones, such as the breast and prostate. Table 1 summarizes the serum, and in most cases, the tissue levels of sex hormones, both endogenously and exogenously ingested, which are associated with increased risk for endocrine-associated cancers such as breast, endometrium, and prostate, as well as the hormone levels of four experimental models that have been shown to elicit high tumor incidences. In contrast to the human, in which the hormone levels are cyclic, however, the latter require continuous hormone exposure at these relatively low levels.

• Hormonal Carcinogenesis
• carcinogenesis
• cell
• genetics
• hormones
• molecular genetics
• ovarian cancer
• prevention
• prostate cancer
• tumor

• Division of Etiology & Prevention of Hormonal Cancers Kansas Cancer Intitute, University of Kansas Medical Center, Kansas City, USA

  Jonathan J. Li, Sara Antonia Li

• Division of Public Health Sciences Fred Hutchinson Cancer Research Center, University of Washington, Seattle, USA

  Janet R. Daling

Policies and ethics