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Birkhäuser

Pharmacology of Endogenous Neurotoxins

A Handbook

  • Book
  • © 1998

Overview

Editors:
  1. Andreas Moser

    1. Department of Neurology, Medical University of Lübeck, Lübeck, Germany

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-xvii
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  2. Neurotoxins

    1. Front Matter

      Pages 1-1
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    2. Isoquinoline Derivatives

      • Toshimitsu Niwa, Mitsuharu Kajita, Toshiharu Nagatsu
      Pages 3-23

    3. TIQ Derivatives in the Human Central Nervous System

      • Andreas Moser
      Pages 25-40

    4. An Animal Model of Parkinson’s Disease Prepared by Endogenous N -Methyl(R)Salsolinol

      • Makoto Naoi, Wakako Maruyama, Philippe Dostert
      Pages 41-61

    5. Putative Endogenous Neurotoxins Derived from the Biogenic Amine Neurotransmitters

      • Glenn Dryhurst
      Pages 63-128

    6. β-Carboline Derivatives as Neurotoxins

      • Michael A. Collins, Edward J. Neafsey
      Pages 129-149

    7. Highly Halogenated Tetrahydro-β-Carbolines as a New Class of Dopaminergic Neurotoxins

      • Gerhard Bringmann, Doris Feineis, Christoph Grote, Ralf God, Hans-Willi Clement, Karl-Heinz Sontag et al.
      Pages 151-169

    8. pros-Methylimidazoleacetic Acid: A Potential Neurotoxin in Brain?

      • George D. Prell
      Pages 171-187

  3. Metabolism

    1. Front Matter

      Pages 189-189
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    2. Bioactivation of Azaheterocyclic Amines via S-Adenosyl-L-Methionine-Dependent N-Methyltransferases

      • Kazuo Matsubara
      Pages 191-208

    3. Tyrosine Hydroxylase: Biochemical Properties and Short-term Regulation in vitro and in vivo

      • Yoko Hirata
      Pages 209-220

    4. Tyrosine Hydroxylase and Endogenous Neurotoxins

      • Joachim Scholz, Andreas Moser
      Pages 221-236

    5. Monoamine Oxidase: Interaction with Isoquinoline Derivatives

      • Clemens Neusch, Andreas Moser
      Pages 237-252

    6. Toxicity and Pharmacological Effects of Salsolinol in Different Cultivated Cells

      • Matthias F. Melzig, Ingo Putscher, Hanka Haber, Matthias Rottmann, Josef Zipper
      Pages 253-266

  4. Back Matter

    Pages 267-273
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Keywords

About this book

It is a great pleasure to write the foreword to this important volume for several reasons. First: As far as we know, already primitive societies had to cope with environmental toxins of many kinds and set up regulations to limit their effects on food and drug use. Modem science, synthesizing tens of millions of new compounds has incredibly magnified this challenge. Today, xenobiotic metabolism has become a crucial task for humans and many other species alike. Second: When reading this book, one is impressed by the extraordinary speed at which neurotoxicology has advanced. Obviously, processing (and endogenous formation) oftox­ ins has become an extremely relevant topic. When I had the chance, almost three decades ago, to work in chemical pharmacology with Bernard B. Brodie at NIH, the drug metabo­ lizing system of the liver had just been recognized and characterized. We had just started to work on the biogenic amines, newly discovered cyclic nucleotides in rat brain, human cere­ brospinal fluid, and on the effects of toxic drugs like amphetamines. Today, biochemical neuropharmacology is a mature field of neuroscience.

Editors and Affiliations

  • Department of Neurology, Medical University of Lübeck, Lübeck, Germany

    Andreas Moser

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