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G Proteins, Receptors, and Disease

  • Book
  • © 1998

Overview

Editors:
  1. Allen M. Spiegel

    1. National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Contemporary Endocrinology (COE, volume 6)

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. Introduction to G-Protein-Coupled Signal Transduction and Human Disease

    • Allen M. Spiegel
    Pages 1-21

  3. Albright Hereditary Osteodystrophy, Pseudohypoparathyroidism, and Gs Deficiency

    • Lee S. Weinstein
    Pages 23-56

  4. Gαs-Activating Mutations

    • Allen M. Spiegel
    Pages 57-69

  5. Ulcerative Colitis in Mice Lacking Gαi2

    • Uwe Rudolph, Lutz Birnbaumer
    Pages 71-83

  6. G Proteins Regulating Insulin Action and Obesity

    • Craig C. Malbon, Patricia Galvin-Parton, Hsien-yu Wang, Christopher M. Moxham
    Pages 85-99

  7. Gα12- and Gα13-Subunits of Heterotrimeric G-Proteins A Novel Family of Oncogenes

    • J. Silvio Gutkind, Omar A. Coso, Ningzhi Xu
    Pages 101-117

  8. Hypo- and Hyperthyroidism Caused by Mutations of the TSH Receptor

    • Gilbert Vassart
    Pages 119-138

  9. Disorders Caused by Mutations of the Lutropin/ Choriogonadotropin Receptor Gene

    • Andrew Shenker
    Pages 139-152

  10. Inactivating and Activating Mutations of the FSH Receptor Gene

    • Ilpo T. Huhtaniemi
    Pages 153-165

  11. Nephrogenic Diabetes Insipidus and Vasopressin Receptor Mutations

    • Daniel G. Bichet
    Pages 167-179

  12. Disorders with Increased or Decreased Responsiveness to Extracellular Ca2+ Owing to Mutations in the Ca2+ o-Sensing Receptor

    • Edward M. Brown, Martin Pollak, Mei Bai, Steven C. Hebert
    Pages 181-204

  13. Constitutively Active PTH/PTHrP Receptors Cause Jansen’s Metaphyseal Chondrodysplasia

    • Harald Jüppner
    Pages 205-216

  14. Mutation of the Growth Hormone-Releasing Hormone Receptor in the little Mouse

    • Kelly E. Mayo, Venita I. DeAlmeida, Kenneth C. Wu
    Pages 217-229

  15. Functional Variants of the MSH Receptor (MC1-R), Agouti, and Their Effects on Mammalian Pigmentation

    • Dongsi Lu, Carrie Haskell-Luevano, Dag Inge Vage, Roger D. Cone
    Pages 231-259

  16. ACTH Resistance Syndromes

    • Constantine Tsigos, George P. Chrousos
    Pages 261-269

  17. Altering Adrenergic Signaling and Cardiac Function in Transgenic Mice

    • Walter J. Koch, Robert J. Lefkowitz
    Pages 271-283

  18. Dopamine Receptors in Human Disease

    • Domenico Accili, John Drago, Sara Fuchs
    Pages 285-299

  19. The β3-Adrenergic Receptor and Susceptibility to Obesity, the Insulin Resistance Syndrome, and Noninsulin-Dependent Diabetes Mellitus

    • Jeremy Walston, Kristi Silver, Alan R. Shuldiner
    Pages 301-319

  20. Back Matter

    Pages 321-324
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Keywords

About this book

More than a collection of review articles, G Proteins, Receptors, and Disease summarizes in depth the state of our knowledge today concerning not only how cells communicate via G-protein-coupled signal transduction processes, but also how defects in these proteins and their receptors can cause serious human disease involving many different organ systems. Written by leading investigators, each chapter describes in detail the structure and function of a particular G protein or receptor, outlines possible mutations, and discusses fully the molecular pathogenesis of associated diseases. Diagnostic and therapeutic implications are also discussed when relevant.

In its unique blend of cutting-edge basic science and clinical medicine, G Proteins, Receptors, and Disease offers deep insights into the physiological significance of this key signal transduction pathway, as well as into the molecular basis of diseases ranging from obesity to malignancy. The basic understanding of the complex signal transduction process achieved here provides a firm foundation for future efforts to prevent and cure these diseases.

Reviews

Winner of one of the Best 1998 Health Sciences Books Awards!
"The book meets the stated objective. . .[of] providing the reader with a complete review of the known molecular and genetic details of the G protein signal cascade and related diseases. . .Each chapter is truly a state-of-the-art description."4 Stars!-Doody's Health Sciences Book Review Journal

"...attractive in its presentation and well illustrated with good quality photographs. . .bibliographies are current and extensive. . .a pleasure to read. . .would complement every medical library and should be highly recommended to clinical and basic scientists."-European Journal of Endocrinology

"G Proteins, Receptors, and Disease is a volume worthy of a place on the bookshelf of anyone with a current interest in endocrine disease and GPCR-targeted approaches to therapeutics....it is refreshing to find a book that communicates just how much genomics-based research can accelerate understanding, not just of a discrete area of science, but of human disease."- Nature Medicine

Editors and Affiliations

  • National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, USA

    Allen M. Spiegel

Bibliographic Information

  • Book Title: G Proteins, Receptors, and Disease

  • Editors: Allen M. Spiegel

  • Series Title: Contemporary Endocrinology

  • DOI: https://doi.org/10.1007/978-1-4612-1802-9

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1998

  • Hardcover ISBN: 978-0-89603-430-3Published: 23 January 1998

  • Softcover ISBN: 978-1-4612-7290-8Published: 09 October 2012

  • eBook ISBN: 978-1-4612-1802-9Published: 06 December 2012

  • Series ISSN: 2523-3785

  • Series E-ISSN: 2523-3793

  • Edition Number: 1

  • Number of Pages: X, 324

  • Topics: Endocrinology

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