The P2 Nucleotide Receptors

1. Front Matter

   Pages i-xi

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2. Historical Perspectives of P2 Nucleotide Receptors

   1. Front Matter

      Pages 1-1

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   2. History of Extracellular Nucleotides and Their Receptors

      • Geoffrey Burnstock

      Pages 3-40

3. Pharmalogical and Molecular Characterization of P2 Nucleotide Receptors

   1. Front Matter

      Pages 41-41

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   2. P2X Receptors

      • Richard J. Evans, Annmarie Surprenant, R. Alan North

      Pages 43-61

   3. The Cloning and Expression of G Protein-Coupled P2Y Nucleotide Receptors

      • Gary A. Weisman, Fernando A. Gonzalez, Laurie Erb, Richard C. Garrad, John T. Turner

      Pages 63-79

   4. Structure Activity Relationships of P2 Receptor Agonists and Antagonists

      • Kenneth A. Jacobson, Yong-Chul Kim, Emidio Camaioni, A. Michiel van Rhee

      Pages 81-107

   5. Pharmacological Selectivities of Molecularly Defined Subtypes of P2Y Receptors

      • T. Kendall Harden, Robert A. Nicholas, Joel B. Schachter, Eduardo R. Lazarowski, José L. Boyer

      Pages 109-134

   6. P2 Receptor Modeling and Identification of Ligand Binding Sites

      • A. Michiel van Rhee, Kenneth A. Jacobson, Richard Garrad, Gary A. Weisman, Laurie Erb

      Pages 135-166

4. Mechanisms of P2 Nucleotide Receptor Action

   1. Front Matter

      Pages 167-167

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   2. Nucleotide Receptors Coupling to the Phospholipase C Signaling Pathway

      • Jean-Marie Boeynaems, Didier Communi, Rodolphe Janssens, Serge Motte, Bernard Robaye, Sabine Pirotton

      Pages 169-183

   3. Cyclic AMP and Tyrosine Kinase Cascades in the Regulation of Cellular Function by P2Y Nucleotide Receptors

      • Michael R. Boarder

      Pages 185-209

   4. Characteristics of Ligand-Gated Ion Channel P2 Nucleotide Receptors

      • Charles Kennedy, Suzanne E. Hickman, Samuel C. Silverstein

      Pages 211-230

   5. Cell Responses Initiated by Ecto-Kinases

      • Jeffrey S. Fedan

      Pages 231-255

5. Physiological and Therapeutic Roles of P2 Nucleotide Receptors

   1. Front Matter

      Pages 257-257

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   2. Functions of Extracellular Nucleotides in Peripheral and Central Neuronal Tissues

      • Eugene M. Silinsky, Ivar von Kügelgen, Andrew Smith, David P. Westfall

      Pages 259-290

   3. Role of Purinoceptors in the Regulation of Lung Surfactant Secretion

      • Seamus A. Rooney

      Pages 291-318

   4. The Role of Nucleotide Receptors in the Cardiovascular System

      • Sabine Pirotton, Claude Desgranges, Guy Vassort, Jean-Marie Boeynaems

      Pages 319-359

   5. Physiological Roles for P2 Receptors in Platelets, Visceral Smooth Muscle, and the Immune and Endocrine Systems

      • Susanna Hourani, Francesco Di Virgilio, Marie-Madeleine Loubatières-Mariani

      Pages 361-411

   6. Therapeutic Applications for Nucleotides in Lung Disease

      • Scott H. Donaldson, Richard C. Boucher

      Pages 413-424

A state-of-the-art summary from leading laboratories around the world of our current knowledge of the molecular biology, the physiology, and the pharmacology of the P2 receptors. The authoritative contributions cover the major aspects of these receptors, describing the relationships between physiological and pharmacological effects of ATP and other nucleotides and the various cloned P2 receptors, as well as providing an historical perspective and discussing current issues of nomenclature. They also illuminate how P2 receptor structures contribute to their function, including the physical differences underlying the pharmacological and functional variations among P2 receptor subtypes.

• molecular biology
• physiology
• platelets
• regulation
• smooth muscle
• tissue

"This book is...very timely...essential reading...really useful and encyclopaedic information."-Journal of Chemical Neuroanatomy

• Department of Pharmacology, University of Missouri-Columbia, USA

  John T. Turner, Gary A. Weisman

• Physiology Section, National Institute for Occupational Safety and Health, Morgantown, USA

  Jeffrey S. Fedan

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