Nutrients in Cancer Prevention and Treatment

1. Front Matter

   Pages i-ix

   PDF

2. Carcinogenesis

   1. Front Matter

      Pages 1-1

      PDF

   2. G protein Pathways and Regulation of Neoplastic Transformation

      • Jianghao Chen, Michael DeVivo, Ravi Iyengar

      Pages 3-18

3. Cancer Prevention Studies: Lab Studies

   1. Front Matter

      Pages 19-19

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   2. Vitamin E Succinate Inhibits Protein Kinase C: Correlation with its Unique Inhibitory Effects on Cell Growth and Transformation

      • R. Gopalakrishna, U. Gundimeda, Z. Chen

      Pages 21-37

   3. Vitamin E Succinate: Mechanisms of Action as Tumor Cell Growth Inhibitor

      • Kimberly Kline, Weiping Yu, Bihong Zhao, Karen Israel, April Charpentier, Marla Simmons-Menchaca et al.

      Pages 39-56

   4. Vitamin D, Gene Expression, and Cancer

      • Hector F. DeLuca

      Pages 57-69

   5. Mechanisms of Cancer Prevention: Effects of Protease Inhibitors on Proteases and Gene Expression

      • Ann R. Kennedy

      Pages 71-82

   6. Antioxidants and Cancer Prevention

      • Andrija Kornhauser, Lark A. Lambert, Wayne G. Wamer, Rong Rong Wei, Sukadev Lavu, William C. Timmer

      Pages 83-100

   7. Ascorbic Acid and Gastrointestinal Cancer

      • Marvin Cohen, Hemmi N. Bhagavan

      Pages 101-118

   8. Biochemistry and Pharmacology of Retinoids in Relation to Chemoprevention of Cancer

      • Donald L. Hill, Tzu-Wen Shih, Tsu-Han Lin, Y. Fulmer Shealy

      Pages 119-136

   9. Involvement of Retinoic Acid Nuclear Receptors in Transcriptional Regulation of Tissue Transglutaminase, the Gene Involved in Apoptosis

      • Ajit K. Verma, Mitchell F. Denning

      Pages 137-156

   10. Mechanisms of Dietary Fat-Induced Colon Cancer Promotion

       • Bandaru S. Reddy

       Pages 157-171

   11. Calories and Exercise as Modifiers of Cancer Risk

       • E. B. Thorling, N. O. Jacobsen

       Pages 173-189

   12. Polycyclic Aromatic Hydrocarbon-DNA Adducts in Smokers and Their Relationship to Micronutrient Levels and Glutathione-S-Transferase M1 Genotype

       • Ricardo A. Grinberg-Funes, Vishwa N. Singh, Frederica P. Perera, Douglas A. Bell, Tie Lan Young, Christopher Dickey et al.

       Pages 191-209

   13. Aspects of Commerical Deep-fat Frying of Fallafel and Its Relation to Liver Tumor

       • I. A. Sadek, S. S. A. Zeyadah, H. M. Ismail, S. I. Saleh

       Pages 211-219

4. Cancer Prevention Studies: Human Studies

   1. Front Matter

      Pages 221-221

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   2. Antioxidant Vitamins and Cancer: the Physicians’ Health Study and Women’s Health Study

      • Julie E. Buring, Charles H. Hennekens

      Pages 223-234

   3. Beta-carotene and Antioxidant Nutrients in Oral Cancer Prevention

      • Harinder Garewal

      Pages 235-247

   4. Nutritional Prevention Trials for Colorectal Neoplasia

      • E. Robert Greenberg

      Pages 249-261

Nutrients in Cancer Prevention and Treatment contains articles that were presented by leading researchers and physicians in the field of nutritional oncology. Most of the previous conference proceedings on Nutrition and Cancer have dealt primarily with the issue of the role of nutrients in cancer prevention. This is logical because enormous quantities of laboratory and epi­ demiologic data have been published on the topic. Nutrients in Cancer Prevention and Treatment also contains several studies on the role of diet and vitamins in cancer treat­ ment. There are very few books that have reviewed laboratory and clinical studies and the role of vitamins in cancer treatment. There are preliminary data suggesting that daily supplementa­ tion with high doses of certain vitamins in combination with conventional therapeutic agents may enhance their growth inhibitory effects on tumor cells, and may protect normal tissues against some of their toxic effects. This book is unique in the sense that several articles have discussed the mechanisms of action of individual vitamins on cellular and molecular parameters. It is very exciting to note that some of the vitamins inhibit protein kinase C activity, increase the production of certain growth factors, and modulate the expression of a number of oncogenes. These studies, at least in part, offer rationales for the cancer protective effects of vitamins.

• Colon
• Glutamin
• Vitamin
• Vitamin A
• Vitamin D
• Vitamin E
• apoptosis
• biochemistry
• cancer
• cancer prevention
• gene expression
• nutrition
• prevention
• transcription
• tumor growth

• University of Colorado Health Sciences Center, Denver, USA

  Kedar N. Prasad

• University of Pavia, Italy

  Leonida Santamaria

• Cancer Treatment Center of America, Des Moines, USA

  R. Michael Williams

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