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Renal Denervation

A New Approach to Treatment of Resistant Hypertension

  • Book
  • © 2015

Overview

Editors:
  1. Richard R. Heuser

    1. St. Luke's Medical Center, Phoenix, USA

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  2. Markus Schlaich

    1. Baker IDI Heart and Diabetes Institute, Melbourne, Australia

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  3. Horst Sievert

    1. CardioVascular Center Frankfurt Sankt Katharinen, Frankfurt, Germany

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  • Provides the most comprehensive and succinct review of renal denervation
  • Discusses rationale, long-term benefits and possible risks of this new therapy, current devices, trials and critical appraisal of clinical data, cost effectiveness and future applications
  • Authored by internationally renowned experts in the field of Renal Denervation and Cardiology

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Table of contents (24 chapters)

  1. Front Matter

    Pages i-xiv
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  2. Pathophysiology: The Target for Renal Denervation

    • Michael Böhm, Dominik Linz, Christian Ukena, Felix Mahfoud
    Pages 1-7

  3. Physiological Rationale for Renal Denervation Therapy in Hypertension

    • C. Venkata S. Ram, A. Sreenivas Kumar
    Pages 9-13

  4. Preclinical Model and Histopathology Translational Medicine and Renal Denervation

    • Kenichi Sakakura, Elena Ladich, Fumiyuki Otsuka, Kazuyuki Yahagi, Frank D. Kolodgie, Michael Joner et al.
    Pages 15-24

  5. The Endpoint on Measuring the Clinical Effects of Renal Denervation: What Are the Best Surrogates

    • Paul A. Sobotka, David G. Harrison, Marat Fudim
    Pages 25-43

  6. Appraisal of the Clinical Trial Data on Renal Denervation for the Management of Resistant Hypertension

    • Aung Myat, Deepak L. Bhatt
    Pages 45-57

  7. Catheter-Based Technology Alternatives for Renal Denervation: An Overview

    • Stefan C. Bertog, Horst Sievert
    Pages 59-60

  8. Medtronic Ardian Symplicity™ Renal Denervation Devices

    • Krishna J. Rocha-Singh
    Pages 61-68

  9. Sympathetic Renal Denervation Using the EnligHTN Multi-electrode Ablation System: The St Jude Experience

    • Costas Tsioufis, Michael Doumas, Charles Faselis, Vasilios Papademetriou
    Pages 69-79

  10. ReCor Medical Paradise® Renal Denervation System

    • Marc Sapoval, Atul Pathak, Leslie A. Coleman, Austin R. Roth, Helen L. Reeve, Thomas Zeller
    Pages 81-89

  11. Therapeutic Intra Vascular Ultrasound (TIVUS)

    • Sharad V. Shetty, Sandeep Chopra
    Pages 91-96

  12. The “OneShot” Irrigated Balloon-Mounted Spiral Electrode Renal Denervation Device

    • William E. L. Ormiston, John A. Ormiston
    Pages 97-100

  13. NOVOSTE: The Brachytherapy Approach to Renal Denervation

    • Nevin C. Baker, Israel M. Barbash, Ron Waksman
    Pages 101-105

  14. Perivascular Renal Denervation (PVRDTM): Chemical Renal Denervation with Micro-Doses of Ethanol Using the PeregrineTM Renal Denervation Device

    • Tim A. Fischell, Félix Vega, Vartan E. Ghazarossian
    Pages 107-116

  15. Vincristine Local Delivery for Renal Artery Denervation

    • Konstantinos Toutouzas, Andreas Synetos, Christodoulos Stefanadis
    Pages 117-123

  16. NephroBlate™ Renal Denervation System: Urologic-Nephrologic Based Approach to Resistant Hypertension

    • Richard R. Heuser, Terrence J. Buelna, Adam Gold, Rahul R. Rao, William G. Van Alstine, Randy I. Cooper et al.
    Pages 125-134

  17. Targeted Renal Nerve Deactivation by Neurotropic Agents

    • Mark H. Wholey, Emily Stein, Michael Evans, K. T. Venkateswara Rao
    Pages 135-143

  18. Boston Scientific Vessix™ Renal Denervation System

    • Stefan C. Bertog, Laura Vaskelyte, Ilona Hofmann, Sameer Gafoor, Horst Sievert
    Pages 145-146

  19. Radiofrequency and Irrigated Ablation: Principles and Potential for Renal Artery Denervation (RDN) in the Treatment of Resistant Arterial Hypertension

    • Kenichi Sakakura, Elena Ladich, Kristine Fuimaono, Renu Virmani, Michael Joner
    Pages 147-154

  20. Renal Denervation: Potential Future Implications Beyond Resistant Hypertension

    • Markus P. Schlaich
    Pages 155-161
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Keywords

About this book

Hypertension remains the leading cause of cardiovascular morbidity and mortality in spite of current medical therapies. It has been estimated that 50% of Western civilization has hypertension and approximately 20% of patients have resistant hypertension. Renal denervation (RDN) is a minimally invasive, endovascular catheter based procedure using radiofrequency ablation aimed at treating resistant hypertension. Early studies show a high degree of effectiveness in renal denervation to treat hypertension.

This book examines renal pathophysiology and the rationale for renal denervation, as well as possible long term benefits and risks of this new therapy.  The myriad of devices involved in the evolution of this therapy are discussed and the book concludes with analyses of the cost effectiveness and future applications.

Reviews

“This book provides a general overview of renal denervation, describing recent studies, current devices, approaches, and possible limitations. … The audience is healthcare providers with an interest in treating patients with resistant hypertension, such as cardiologists and nephrologists. … The figures and tables are well designed and helpful. An extensive list of references concludes chapters. This is a thoughtful, well-written reference on this specific area in the field of hypertension.” (Jon Webb, Doody's Book Reviews, April, 2015)

Editors and Affiliations

  • St. Luke's Medical Center, Phoenix, USA

    Richard R. Heuser

  • Baker IDI Heart and Diabetes Institute, Melbourne, Australia

    Markus Schlaich

  • CardioVascular Center Frankfurt Sankt Katharinen, Frankfurt, Germany

    Horst Sievert

Bibliographic Information

  • Book Title: Renal Denervation

  • Book Subtitle: A New Approach to Treatment of Resistant Hypertension

  • Editors: Richard R. Heuser, Markus Schlaich, Horst Sievert

  • DOI: https://doi.org/10.1007/978-1-4471-5223-1

  • Publisher: Springer London

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer-Verlag London 2015

  • Softcover ISBN: 978-1-4471-7076-1Published: 22 September 2016

  • eBook ISBN: 978-1-4471-5223-1Published: 11 November 2014

  • Edition Number: 1

  • Number of Pages: XIV, 201

  • Number of Illustrations: 8 b/w illustrations, 87 illustrations in colour

  • Topics: Cardiology, Nephrology, Interventional Radiology

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