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Biochemistry of Pulmonary Emphysema

  • Book
  • © 1992

Overview

Editors:
  1. C. Grassi

    1. Institute of Phthisiology and Respiratory Diseases, IRCCS San Matteo, University of Pavia, Italy

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  2. J. Travis

    1. Department of Biochemistry, University of Georgia, Athens, USA

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  3. L. Casali

    1. Postgraduate School of Respiratory Diseases, University of Pavia, Italy

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  4. M. Luisetti

    1. Institute of Phthisiology and Respiratory Diseases, IRCCS San Matteo, University of Pavia, Italy

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Part of the book series: Current Topics in Rehabilitation (CURRENT REHAB)

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Table of contents (14 chapters)

  1. Front Matter

    Pages I-XV
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  2. Pulmonary Emphysema: What’s Going On

    • C. Grassi, M. Luisetti
    Pages 1-11

  3. Elastin and the Lung

    • J. M. Davidson
    Pages 13-25

  4. An Introduction to the Endopeptidases

    • A. J. Barrett
    Pages 27-34

  5. Lung Proteinases and Emphysema

    • J. G. Bieth
    Pages 35-46

  6. Proteinases and Proteinase Inhibitors in the Pathogenesis of Pulmonary Emphysema in Humans

    • R. A. Stockley, D. Burnett
    Pages 47-69

  7. Multiple Functions of Neutrophil Proteinases and their Inhibitor Complexes

    • J. Travis, J. Potempa, N. Bangalore, A. Kurdowska
    Pages 71-79

  8. Kinetics of the Interaction of Human Leucocyte Elastase with Protein Substrates: Implications for Enzyme Inhibition

    • A. Baici
    Pages 81-100

  9. Proteinase Inhibitor Candidates for Therapy of Enzyme-Inhibitor Imbalances

    • H. Fritz, J. Collins, M. Jochum
    Pages 101-112

  10. Antileucoprotease (Secretory Leucocyte Proteinase Inhibitor), a Major Proteinase Inhibitor in the Human Lung

    • J. A. Kramps, J. Stolk, A. Rudolphus, J. H. Dijkman
    Pages 113-121

  11. Synthetic Mechanism-Based and Transition-State Inhibitors for Human Neutrophil Elastase

    • J. C. Powers, C.-M. Kam, H. Hori, J. Oleksyszyn, E. F. Meyer Jr.
    Pages 123-141

  12. Development and Evaluation of Antiproteases as Drugs for Preventing Emphysema

    • G. L. Snider, P. J. Stone, E. C. Lucey
    Pages 143-158

  13. Genetic Control of Human Alpha-1-Antitrypsin and Hepatic Gene Therapy

    • S. L. C. Woo, R. N. Sifers, K. Ponder
    Pages 159-167

  14. Neutrophils, Neutrophil Elastase and the Fragile Lung: The Pathogenesis and Therapeutic Strategies Relating to Lung Derangement in the Common Hereditary Lung Disorders

    • N. G. McElvaney, P. Birrer, L. M. Chang-Stroman, R. G. Crystal
    Pages 169-187

  15. Workshop Summary

    • J. Travis
    Pages 189-192

  16. Back Matter

    Pages 193-200
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Keywords

About this book

Pulmonary emphysema is a disease which develops because of a localized imbalance between endogenous proteinase inhibitors and proteinases leaking from neurophils during phagocytosis at inflammatory foci within the lung. This volume not only reviews at a biochemical level what is known about the natural inhibitors and proteinases involved in connective tissue destruction within the lung, but also suggests novel methodologies for reestablishing proper enzyme-inhibitor balance, including the use of natural or synthetic inhibitors for supplementation or gene therapy.

Editors and Affiliations

  • Institute of Phthisiology and Respiratory Diseases, IRCCS San Matteo, University of Pavia, Italy

    C. Grassi, M. Luisetti

  • Department of Biochemistry, University of Georgia, Athens, USA

    J. Travis

  • Postgraduate School of Respiratory Diseases, University of Pavia, Italy

    L. Casali

Bibliographic Information

  • Book Title: Biochemistry of Pulmonary Emphysema

  • Editors: C. Grassi, J. Travis, L. Casali, M. Luisetti

  • Series Title: Current Topics in Rehabilitation

  • DOI: https://doi.org/10.1007/978-1-4471-3771-9

  • Publisher: Springer London

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag London 1992

  • Softcover ISBN: 978-1-4471-3773-3Published: 09 April 2014

  • eBook ISBN: 978-1-4471-3771-9Published: 11 November 2013

  • Series ISSN: 1431-2093

  • Edition Number: 1

  • Number of Pages: XV, 200

  • Number of Illustrations: 13 b/w illustrations

  • Additional Information: Jointly published with Bi & Gi Publishers, Verona, Italy

  • Topics: Rehabilitation, Pneumology/Respiratory System, Biochemistry, general, Pharmacology/Toxicology

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