Bone Metastases

1. Front Matter

   Pages i-xii

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2. The Nature of Metastatic Bone Disease

   • R. D. Rubens

   Pages 1-10

3. Normal Bone Remodelling and Its Disruption in Metastatic Bone Disease

   • B. F. Boyce

   Pages 11-30

4. The Bone Scan in Metastatic Disease

   • I. Fogelman, J. H. McKillop

   Pages 31-61

5. Radiology

   • Sheila Rankin

   Pages 63-81

6. Magnetic Resonance Imaging

   • M. A. Richards

   Pages 83-97

7. Assessment of Response to Treatment

   • R. E. Coleman

   Pages 99-120

8. The Systemic Treatment of Bone Metastases

   • D. J. Dodwell, A. Howell

   Pages 121-147

9. Pathogenesis and Management of Cancer-Associated Hypercalcaemia

   • S. H. Ralston

   Pages 149-169

10. Radiotherapy in the Management of Bone Metastases

    • P. J. Hoskin

    Pages 171-185

11. Isotope Therapy For Bone Metastases

    • Susan E. M. Clarke

    Pages 187-205

12. The Role of the Orthopaedic Surgeon in the Treatment of Skeletal Metastases

    • C. S. B. Galasko

    Pages 207-222

13. Symptomatic and Supportive Care

    • C. Terrell, J. R. Wedley

    Pages 223-241

14. Back Matter

    Pages 243-247

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Bone Metastases brings together the many recent developments that are gradually improving the prospects for patients with secondary involvement of the skeleton in a primary cancer elsewhere. The morbidity from bone metastases is extensive, and the palliative and supportive treatment that sufferers require for many months or even years constitutes a major health problem. A multidisciplinary approach is essential since a variety of specialists are involved: radiation and medical oncologists, general and orthopaedic surgeons, general physicians, radiologists and nuclear medicine physicians, symptom control and terminal care specialists. The book's editors, themselves authorities in the fields of oncology and bone disease respectively, have brought together experts from all these disciplines to provide comprehensive coverage of metastatic bone disease. They cover the biology and pathophysiology, hypercalcaemia, imaging, assessment of response to treatment, types of treatment (systemic, radiotherapy, surgery), and symptomatic and supportive care. Particularly new approaches included are magnetic resonance imaging, the assessment of skeletal response and isotope therapy.

• bone
• cancer
• computed tomography (CT)
• imaging
• magnetic resonance
• magnetic resonance imaging
• magnetic resonance imaging (MRI)
• metastasis
• metastatic disease
• morbidity
• pathogenesis
• pathophysiology
• radiation
• radiology
• radiotherapy

• Imperial Cancer Research Fund Clinical Oncology Unit, United Medical and Dental Schools of Guy’s and St Thomas’s Hospitals, Guy’s Hospital, London, UK

  R. D. Rubens

• Department of Nuclear Medicine, Guy’s Hospital, London, UK

  I. Fogelman

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