Therapeutic Antibodies

1. Front Matter

   Pages i-xii

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2. An Introduction to the Clinical Applications of Antibodies

   • J. Landon, T. Chard, R. E. Coxon

   Pages 1-32

3. Biology of the Immune Response

   • T. Poulton, F. Hay

   Pages 33-45

4. Antibody Production in the Hen

   • J. Landon, J. A. Woolley, C. McLean

   Pages 47-68

5. Catalytic Antibodies

   • G. Gallacher

   Pages 69-87

6. Immunotherapy for Drug Toxicity

   • A. J. Heath

   Pages 89-108

7. Therapeutic Antibodies to Snake Venoms

   • R. D. G. Theakston, D. C. Smith

   Pages 109-133

8. Therapeutic Antibodies to Tumours

   • J. A. Ledermann

   Pages 135-151

9. Therapeutic Antibodies to Microorganisms

   • P. L. Yap

   Pages 153-176

10. Immunological Therapy of Endotoxaemia: Anti-endotoxin Antibodies

    • A. P. Wheeler, G. R. Bernard

    Pages 177-198

11. Cytokine Antibodies and Antagonists in the Treatment of Sepsis

    • A. P. Wheeler, K. L. Brigham

    Pages 199-224

12. Back Matter

    Pages 225-231

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Several aspects of clinical medicine are poised on the edge of a new era with the introduction of therapeutic antibodies. This revolution has been made possible by major advances in immune technology, which are now beginning to mature into clinical practice. This volume is aimed at all clinicians involved with this form of treatment, especially accident and emergency physicians, clinical immunologists, and pharmacologists. It covers both the basic technology, and also all the main clinical areas of application: septic shock, auto-immune disease, and cancer. The future of therapeutic antibodies is also discussed, including exciting new developments in "catalytic antibodies". This is the first occasion on which all these topics have been brought together in a single volume, thus making it an important reference source for physicians and researchers in this fast-moving area.

• Sepsis
• TNF
• antibody
• cancer
• cell
• cytokines
• immune system
• immunology
• immunotherapy
• infection
• inflammation
• pharmacology
• prevention
• shock
• tumor
• antibodies

• Department of Chemical Pathology, St Bartholomew’s Hospital Medical College, London, UK

  John Landon

• Joint Academic Unit of Obstetrics, Gynaecology and Reproductive Physiology, St Bartholomew’s Hospital Medical College, London, UK

  Tim Chard

Policies and ethics