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Antenatal Diagnosis of Fetal Abnormalities

  • Book
  • © 1991

Overview

Editors:
  1. James O. Drife

    1. Clarendon Wing, Leeds General Infirmary, Leeds, UK

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    You can also search for this editor in PubMed   Google Scholar

  2. Dian Donnai

    1. Department of Medical Genetics, St Mary’s Hospital, Manchester, UK

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    You can also search for this editor in PubMed   Google Scholar

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Table of contents (26 chapters)

  1. Front Matter

    Pages i-xv
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  2. Epidemiology and Routine Screening

    1. Front Matter

      Pages 1-1
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    2. Trends in Prevalence of Congenital Abnormalities

      • N. C. Nevin
      Pages 3-11

    3. The Northern Regional Fetal Abnormality Survey

      • A. F. J. Atkins, E. N. Hey
      Pages 13-34

    4. Routine Fetal Anomaly Screening

      • M. J. Whittle
      Pages 35-43

    5. Some Practical Issues in the Antenatal Detection of Neural Tube Defects and Down’s Syndrome

      • N. Wald, H. Cuckle
      Pages 45-57

    6. Heterozygote Screening for Cystic Fibrosis

      • D. J. H. Brock, M. E. Mennie, I. McIntosh, C. Jones, A. E. Shrimpton
      Pages 59-70

  3. Special Techniques: 1

    1. Front Matter

      Pages 71-71
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    2. Chorion Villus Sampling: The MRC European Trial

      • T. W. Meade
      Pages 73-77

    3. Invasive Diagnostic Procedures in the First Trimester

      • R. J. Lilford
      Pages 79-95

    4. Cardiac Ultrasound Scanning

      • L. D. Allan
      Pages 97-111

    5. Doppler Ultrasound Studies and Fetal Abnormality

      • B. J. Trudinger
      Pages 113-125

  4. DNA Analysis

    1. Front Matter

      Pages 127-127
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    2. Overview of Linkage and Probes

      • M. E. Pembrey
      Pages 129-136

    3. Diagnosis of Genetic Defects in Eggs and Embryos

      • M. Monk
      Pages 137-149

  5. Cytogenetic and Biochemical Disorders

    1. Front Matter

      Pages 151-151
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    2. Fetal Karyotyping Using Chorionic Villus Samples

      • C. M. Gosden
      Pages 153-167

    3. Prenatal Diagnosis of the Fragile-X Syndrome

      • T. Webb
      Pages 169-181

    4. Advances in Diagnosis of Biochemical Disorders

      • H. Galjaard
      Pages 183-198

  6. Special Techniques: 2

    1. Front Matter

      Pages 199-199
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Keywords

About this book

In few areas of medicine is progress more spectacular than in the field of prenatal diagnosis. New clinical techniques such as chorion villus sampling, detailed ultrasound scanning and cordocentesis are being evaluated by obstetricians, and refinement of biochemical testing is widening the scope of maternal serum screening. In the laboratory, dramatic advances in molecular biology are occurring: families at risk of genetic disease can be investigated with gene probes, and preimplantation diagnosis of the embryo is now becom­ ing a reality. These technical advances have important ethical and practical implications, among which will be a further increase in public expectations of the standards required of antenatal services. Clini­ cians will need a high degree of skill to inform healthy women about the options for screening normal pregnancies, and to counsel high-risk women about the benefits and limitations of prenatal diagnosis. Obstetricians, scientists and health service managers will face the difficult task of deciding how prenatal diagnosis can be made available to women in a caring and cost-effective way. Recognising the rapid progress in this field, the Royal College of Obstetricians and Gynaecologists made prenatal diagnosis the subject of its 23rd Study Group. An international panel of leading researchers, whose expertise ranged from molecular biology to philosophy, was invited to participate in a three day workshop, with time for in-depth discussion as well as the presentation of papers.

Editors and Affiliations

  • Clarendon Wing, Leeds General Infirmary, Leeds, UK

    James O. Drife

  • Department of Medical Genetics, St Mary’s Hospital, Manchester, UK

    Dian Donnai

Bibliographic Information

  • Book Title: Antenatal Diagnosis of Fetal Abnormalities

  • Editors: James O. Drife, Dian Donnai

  • DOI: https://doi.org/10.1007/978-1-4471-1854-1

  • Publisher: Springer London

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag London Limited 1991

  • Softcover ISBN: 978-1-4471-1856-5Published: 25 November 2011

  • eBook ISBN: 978-1-4471-1854-1Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XIV, 363

  • Topics: Obstetrics/Perinatology/Midwifery, Cell Biology, Pediatrics, Orthopedics, Human Genetics

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