Platelet-Vessel Wall Interactions

1. Front Matter

   Pages i-xiv

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2. The Platelet

   • Ian J. Mackie, Christopher R. Neal

   Pages 1-32

3. Endothelium and the Vessel Wall

   • R. Michael Pittilo

   Pages 33-59

4. The use of Cultured Endothelial Cells in the Study of Platelet-Vessel Wall Interactions

   • Helen A. Bull

   Pages 61-86

5. Smoking and Platelet-Vessel Wall Interactions

   • R. Michael Pittilo

   Pages 87-101

6. Mesothelium as a Non-thrombogenic Surface

   • Carol M. Blow

   Pages 103-119

7. Platelet-Endothelial Interactions in Renal Injury

   • Guy H. Neild, Michael P. Gordge

   Pages 121-153

8. Haemolytic Uraemic Syndrome and Thrombotic Thrombocytopenic Purpura: A Review

   • Guy H. Neild

   Pages 155-165

9. Newer Pharmacological Agents

   • Anne Yardumian, Samuel J. Machin

   Pages 167-191

10. Back Matter

    Pages 193-198

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The publication of Platelet-Vessel Wall Interactions, the second monograph in the Bloomsbury Series in Clinical Science, is particu­ larly welcome as its appearance signifies the further development of the Series and its potential for the future. The theme of this monograph is the pathophysiology of atherosclerosis, a topic that symbolises the aim of the Series, namely to highlight the important interfaces between basic medical science and clinical practice. Our congratulations to the Editors and contributors. London, December 1987 lack Tinker Preface In the Western world, atherosclerosis causes more illness and death than any other disease. Despite its devastating effects, the pathogenesis of the disease remains a matter for hypothesis and con­ jecture. This monograph owes its conception to a programme of work directed towards understanding the basic pathophysiology of atherosclerosis. The circulatory system is lined by vascular endothelium which has a central role in maintaining the integrity of the vessel wall and prevent­ ing thrombosis. The natural equilibrium existing between normal en­ dothelium which supports blood flow, and platelets which serve to re­ pair damaged endothelium, is explored in the first two chapters. Atherosclerosis developing as a response to endothelial injury is one hypothesis which has stimulated widespread interest, and re­ search has largely been directed towards finding the injurious agent.

• atherosclerosis
• blood
• physiology
• platelet
• thrombosis

• Bland-Sutton Institute, Department of Histopathology, The Middlesex Hospital, London, UK

  R. Michael Pittilo

• Department of Analytical and Biological Chemistry, Kingston Polytechnic, Kingston-upon-Thames, Surrey, UK

  R. Michael Pittilo

• Department of Haematology, School of Pathology, The Middlesex Hospital, London, UK

  Samuel J. Machin

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