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Multiple Sclerosis

Advances in Clinical Trial Design, Treatment and Future Perspectives

  • Book
  • © 1996

Overview

Editors:
  1. Donald E. Goodkin

    1. The UCSF/Mount Zion Multiple Sclerosis Center, University of California at San Francisco, San Francisco, USA

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  2. Richard A. Rudick

    1. Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic Foundation, Cleveland, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Covers the important new developments in clinical trial design and a number of important trial results that have resulted in new treatment options for patients and physicians *
  • Important ethical considerations that arise with new treatments are included, as is a perspective on the emergence of MS as a treatable disease * Will be of interest to both specialists and general practitioners alike * Also will be of value to clinical epidemiologists and biostatisticians with an interest in experimental therapies for chronic disease, to immunologists with an interest in autoimmune disease, and to the pharmaceutical industry and to Multiple Sclerosis societies

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-xviii
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  2. Recent Advances and Future Challenges in Multiple Sclerosis Clinical Trial Design

    • George W. Ellison
    Pages 1-15

  3. Pathogenesis of Multiple Sclerosis: Relationship to Therapeutic Strategies

    • Jorge R. Oksenberg, Stephen L. Hauser
    Pages 17-46

  4. Future of Multiple Sclerosis Therapeutics: Rational Approaches Targeting Putative Pathogenic Mechanisms

    • Subramaniam Sriram
    Pages 47-62

  5. Statistical and Design Considerations for Multiple Sclerosis Clinical Trials

    • John Petkau
    Pages 63-103

  6. Clinical Outcome Measures for Multiple Sclerosis

    • Brian G. Weinshenker
    Pages 105-122

  7. Use of Neuropsychologic Outcome Measures in Multiple Sclerosis Clinical Trials: Current Status and Strategies for Improving Multiple Sclerosis Clinical Trial Design

    • Jill S. Fischer
    Pages 123-144

  8. “Quality of Life” Assessment in Multiple Sclerosis Clinical Trials: Current Status and Strategies for Improving Multiple Sclerosis Clinical Trial Design

    • Nicholas G. LaRocca, Paul G. Ritvo, Deborah M. Miller, Jill S. Fischer, Howard Andrews, Donald W. Paty
    Pages 145-160

  9. Magnetic Resonance Imaging: Current Status and Strategies for Improving Multiple Sclerosis Clinical Trial Design

    • Robert I. Grossman
    Pages 161-186

  10. Magnetic Resonance Imaging of Patients with Isolated Idiopathic Optic Neuritis, Brainstem Syndromes and Myelopathy

    • David H. Miller
    Pages 187-200

  11. Strategies to Delay the Onset of Clinically Definite Multiple Sclerosis in Patients with Monosymptomatic Presentations of Optic Neuritis, Brainstem Syndromes or Myelopathy

    • Roy W. Beck
    Pages 201-221

  12. Treatment of Multiple Sclerosis with Type I Interferons

    • Richard A. Rudick, William Sibley, Luca Durelli
    Pages 223-250

  13. Treatment of Multiple Sclerosis with Methotrexate

    • Donald E. Goodkin, Jill S. Fischer
    Pages 251-287

  14. Treatment of Multiple Sclerosis with Copolymer 1

    • Kenneth P. Johnson, M. B. Bornstein
    Pages 289-312

  15. Treatment of Multiple Sclerosis with Cladribine

    • Jack C. Sipe, J. S. Romine, J. Zyroff, J. Koziol, E. Beutler
    Pages 313-334

  16. Ethical Considerations Raised by Clinical Trials

    • Richard Foa
    Pages 335-349

  17. The Emergence of Multiple Sclerosis as a “Treatable” Condition; An Historical Perspective

    • W. Ian McDonald
    Pages 351-360

  18. Back Matter

    Pages 361-364
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Keywords

About this book

Multiple Sclerosis: Advances in Clinical Trial Design, Treatment and Future Perspectives is a review of therapeutic developments for a disease that is one of the major problems in current neurologic practice. Progress in this field has been rapid and there have been important developments in clinical trial design and a number of important trial results that have resulted in new treatment options for patients and physicians. Important ethical considerations that arise with new treatments are included, as is a perspective on the emergence of MS as a treatable disease. This book is for all neurologists, primary care physicians, and patients concerned about the treatment of MS. It will also be of value to clinical epidemiologists and biostatisticians with an interest in experimental therapies for chronic disease, to immunologists with an interest in autoimmune disease, to the pharmaceutical industry and to MS societies.

Editors and Affiliations

  • The UCSF/Mount Zion Multiple Sclerosis Center, University of California at San Francisco, San Francisco, USA

    Donald E. Goodkin

  • Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic Foundation, Cleveland, USA

    Richard A. Rudick

Bibliographic Information

  • Book Title: Multiple Sclerosis

  • Book Subtitle: Advances in Clinical Trial Design, Treatment and Future Perspectives

  • Editors: Donald E. Goodkin, Richard A. Rudick

  • DOI: https://doi.org/10.1007/978-1-4471-1271-6

  • Publisher: Springer London

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag London Limited 1996

  • Softcover ISBN: 978-1-85233-033-0Published: 26 May 1998

  • eBook ISBN: 978-1-4471-1271-6Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XVIII, 364

  • Number of Illustrations: 4 b/w illustrations

  • Topics: Neurology, Internal Medicine, General Practice / Family Medicine

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