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Epigenetic Alterations in Oncogenesis

  • Book
  • © 2013

Overview

Editors:
  1. Adam R. Karpf

    1. University of Nebraska Medical Center, Eppley Institute for Research in Cancer, Omaha, USA

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  • Epigenetic gene silencing in cancer
  • Gene activation by DNA hypomethylation in oncogenesis
  • Epigenetic cancer biomarkers
  • Epigenetic dysregulation of miRNAs in cancer
  • Includes supplementary material: sn.pub/extras

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-xv
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  2. Epigenetic Marks and Mechanisms

    1. Front Matter

      Pages 1-1
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  3. Epigenetic Marks and Mechanisms

    1. DNA Methyltransferases, DNA Damage Repair, and Cancer

      • Bilian Jin, Keith D. Robertson
      Pages 3-29

    2. DNA Hypomethylation and Hemimethylation in Cancer

      • Melanie Ehrlich, Michelle Lacey
      Pages 31-56

    3. Ten Eleven Translocation Enzymes and 5-Hydroxymethylation in Mammalian Development and Cancer

      • Shannon R. Morey Kinney, Sriharsa Pradhan
      Pages 57-79

    4. Altered Histone Modifications in Cancer

      • Moray J. Campbell, Bryan M. Turner
      Pages 81-107

    5. Nucleosome Occupancy and Gene Regulation During Tumorigenesis

      • C. V. Andreu-Vieyra, G. Liang
      Pages 109-134

  4. The Impact of Epigenetic Alterations on Cancer Biology

    1. Front Matter

      Pages 135-135
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    2. Epigenetic Regulation of miRNAs in Cancer

      • Muller Fabbri, Federica Calore, Alessio Paone, Roberta Galli, George A. Calin
      Pages 137-148

    3. DNA Hypomethylation and Activation of Germline-Specific Genes in Cancer

      • Charles De Smet, Axelle Loriot
      Pages 149-166

    4. APC and DNA Demethylation in Cell Fate Specification and Intestinal Cancer

      • Angela Andersen, David A. Jones
      Pages 167-177

    5. Epigenetic Changes During Cell Transformation

      • Bernard W. Futscher
      Pages 179-194

    6. Epigenetic Reprogramming of Mesenchymal Stem Cells

      • Yu-Wei Leu, Tim H.-M. Huang, Shu-Huei Hsiao
      Pages 195-211

  5. Clinical Implications and Analysis Methods

    1. Front Matter

      Pages 213-213
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    2. Environmental Toxicants, Epigenetics, and Cancer

      • Igor P. Pogribny, Ivan Rusyn
      Pages 215-232

    3. Blood-Derived DNA Methylation Markers of Cancer Risk

      • Carmen Marsit, Brock Christensen
      Pages 233-252

    4. Epigenetic Therapies in MDS and AML

      • Elizabeth A. Griffiths, Steven D. Gore
      Pages 253-283

    5. Epigenetic Targeting Therapies to Overcome Chemotherapy Resistance

      • Curt Balch, Kenneth P. Nephew
      Pages 285-311

    6. Methods for Cancer Epigenome Analysis

      • Raman P. Nagarajan, Shaun D. Fouse, Robert J. A. Bell, Joseph F. Costello
      Pages 313-338

  6. Back Matter

    Pages 339-348
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About this book

The purpose of this book is to provide an up to date review of the nature and consequences of epigenetic changes in cancer. Epigenetics literally means “above” genetics, and consists of heritable gene expression or other phenotypic states not accounted for by DNA base sequence. Epigenetic changes are now known to make a large contribution to various aspects of tumorigenesis. These changes include alterations in global and promoter specific DNA methylation, activating and repressive histone modifications, and changes in higher order chromatin structures. Each of these topics will be covered in this book.

Reviews

From the reviews:

“This well-illustrated book is an excellent source of cutting-edge scientific information on epigenetic marks such as cytosine methylation and cytosine hydroxymethylation, histone tail modifications, histone variants and nucleosome positional information, recognized to play a fundamental role in cancer development and progression. … There are very few books available on this subject. This one will be very useful for students and researchers interested in knowing more about epigenetic alterations in oncogenesis.” (Omer Iqbal, Doody’s Book Reviews, August, 2013)

Editors and Affiliations

  • University of Nebraska Medical Center, Eppley Institute for Research in Cancer, Omaha, USA

    Adam R. Karpf

Bibliographic Information

  • Book Title: Epigenetic Alterations in Oncogenesis

  • Editors: Adam R. Karpf

  • DOI: https://doi.org/10.1007/978-1-4419-9967-2

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2013

  • Hardcover ISBN: 978-1-4419-9966-5Published: 06 September 2012

  • Softcover ISBN: 978-1-4899-8558-3Published: 15 October 2014

  • eBook ISBN: 978-1-4419-9967-2Published: 06 September 2012

  • Edition Number: 1

  • Number of Pages: XVI, 348

  • Topics: Cancer Research, Human Genetics, Oncology

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