Insulin Resistance and Cancer

1. Front Matter

   Pages i-xi

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2. Insulin and the Physiology of Carbohydrate Metabolism

   • Sandra Pereira, Adria Giacca

   Pages 1-52

3. Insulin/IGF-1 Signaling Nodes and their Role in Carcinogenesis

   • Cullen M. Taniguchi, C. Ronald Kahn

   Pages 53-76

4. The Mechanisms and Impact of Obesity and Insulin Resistance on Breast Cancer Incidence

   • Deborah J. Clegg

   Pages 77-99

5. Obesity and Cancer: Epidemiology

   • Melinda L. Irwin

   Pages 101-110

6. Insulin, Insulin Resistance, and Cancer Associations

   • Lorraine Lipscombe

   Pages 111-140

7. Animal Models of Hyperinsulinemia, Insulin Resistance, and Cancer

   • Ruslan Novosyadlyy, Archana Vijayakumar, Yvonne Fierz, Derek LeRoith

   Pages 141-157

8. Potential Mechanisms Linking Insulin to Cancer

   • Yael Babichev, Sarah Khalid, I. George Fantus

   Pages 159-180

9. Actions of Insulin As a Survival and Growth Factor: Akt, mTOR, and Regulation of Translation

   • Luc Furic, Mark Livingstone, Ivan Topisirovic, Nahum Sonenberg

   Pages 181-192

10. AMP-Activated Protein Kinase and Cancer Cell Metabolism

    • Bin Zheng, Lewis C. Cantley

    Pages 193-211

11. The Role of the IGF Axis in Human Malignancy: Evidence from Epidemiological Studies and Tissue Analysis

    • Julia V. Burnier, Shun Li, Pnina Brodt

    Pages 213-242

12. IGF-I and Insulin Receptor Families in Cancer

    • Antonino Belfiore, Ira D. Goldfine, Roberta Malaguarnera

    Pages 243-268

13. Insulin Resistance: Clinical Implications for Cancer Treatment and Prevention

    • Saroj Niraula, Pamela J. Goodwin

    Pages 269-291

14. Back Matter

    Pages 293-298

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This book reviews the epidemiological associations between insulin resistance and cancer. This is followed by reviews of animal models which support this relationship and provide insight into potential mechanisms. Several chapters then provide detailed examination of the cellular and molecular changes characterizing the insulin resistant state, such as hyperinsulinemia, abnormal metabolism and hormone signaling, and how these interact with various tumor characteristics. For example some tumors present increased quantities of the fetal form of the insulin receptor, unique regulation of oxidative (Krebs’ cycle) metabolism (Warburg effect), as well as mutations in various relevant signaling pathways. Finally, the clinical implications of these data are integrated with considerations of insulin “sensitization” and potential metabolic interventions to prevent and treat cancer. It should be noted that while a number of cancers are associated with obesity the authors here have focused primarily on breast cancer as a key and significant model.

• Hyperinsulinemia
• IGF Receptors
• breast cancer
• metabolic syndrome
• obesity

• Mount Sinai Hospital, Dept. Medicine, University of Toronto, Toronto, Canada

  I. George Fantus

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