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Insulin Resistance and Cancer

Epidemiology, Cellular and Molecular Mechanisms and Clinical Implications

  • Book
  • © 2011

Overview

Editors:
  1. I. George Fantus

    1. Mount Sinai Hospital, Dept. Medicine, University of Toronto, Toronto, Canada

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  • In-depth detail of basic concepts of insulin and cancer and how they interact.
  • Reviews the epidemiological associations between insulin resistance and cancer.
  • Focuses primarily on breast cancer as a key and significant model for cancer research and insulin.

Part of the book series: Energy Balance and Cancer (EBAC, volume 1)

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-xi
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  2. Insulin and the Physiology of Carbohydrate Metabolism

    • Sandra Pereira, Adria Giacca
    Pages 1-52

  3. Insulin/IGF-1 Signaling Nodes and their Role in Carcinogenesis

    • Cullen M. Taniguchi, C. Ronald Kahn
    Pages 53-76

  4. The Mechanisms and Impact of Obesity and Insulin Resistance on Breast Cancer Incidence

    • Deborah J. Clegg
    Pages 77-99

  5. Obesity and Cancer: Epidemiology

    • Melinda L. Irwin
    Pages 101-110

  6. Insulin, Insulin Resistance, and Cancer Associations

    • Lorraine Lipscombe
    Pages 111-140

  7. Animal Models of Hyperinsulinemia, Insulin Resistance, and Cancer

    • Ruslan Novosyadlyy, Archana Vijayakumar, Yvonne Fierz, Derek LeRoith
    Pages 141-157

  8. Potential Mechanisms Linking Insulin to Cancer

    • Yael Babichev, Sarah Khalid, I. George Fantus
    Pages 159-180

  9. Actions of Insulin As a Survival and Growth Factor: Akt, mTOR, and Regulation of Translation

    • Luc Furic, Mark Livingstone, Ivan Topisirovic, Nahum Sonenberg
    Pages 181-192

  10. AMP-Activated Protein Kinase and Cancer Cell Metabolism

    • Bin Zheng, Lewis C. Cantley
    Pages 193-211

  11. The Role of the IGF Axis in Human Malignancy: Evidence from Epidemiological Studies and Tissue Analysis

    • Julia V. Burnier, Shun Li, Pnina Brodt
    Pages 213-242

  12. IGF-I and Insulin Receptor Families in Cancer

    • Antonino Belfiore, Ira D. Goldfine, Roberta Malaguarnera
    Pages 243-268

  13. Insulin Resistance: Clinical Implications for Cancer Treatment and Prevention

    • Saroj Niraula, Pamela J. Goodwin
    Pages 269-291

  14. Back Matter

    Pages 293-298
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Keywords

About this book

This book reviews the epidemiological associations between insulin resistance and cancer. This is followed by reviews of animal models which support this relationship and provide insight into potential mechanisms. Several chapters then provide detailed examination of the cellular and molecular changes characterizing the insulin resistant state, such as hyperinsulinemia, abnormal metabolism and hormone signaling, and how these interact with various tumor characteristics. For example some tumors present increased quantities of the fetal form of the insulin receptor, unique regulation of oxidative (Krebs’ cycle) metabolism (Warburg effect), as well as mutations in various relevant signaling pathways. Finally, the clinical implications of these data are integrated with considerations of insulin “sensitization” and potential metabolic interventions to prevent and treat cancer. It should be noted that while a number of cancers are associated with obesity the authors here have focused primarily on breast cancer as a key and significant model.

Editors and Affiliations

  • Mount Sinai Hospital, Dept. Medicine, University of Toronto, Toronto, Canada

    I. George Fantus

Bibliographic Information

  • Book Title: Insulin Resistance and Cancer

  • Book Subtitle: Epidemiology, Cellular and Molecular Mechanisms and Clinical Implications

  • Editors: I. George Fantus

  • Series Title: Energy Balance and Cancer

  • DOI: https://doi.org/10.1007/978-1-4419-9911-5

  • Publisher: Springer New York, NY

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Science+Business Media, LLC 2011

  • Hardcover ISBN: 978-1-4419-9910-8Published: 19 August 2011

  • Softcover ISBN: 978-1-4614-2818-3Published: 19 April 2013

  • eBook ISBN: 978-1-4419-9911-5Published: 19 August 2011

  • Series ISSN: 2199-2622

  • Series E-ISSN: 2199-2630

  • Edition Number: 1

  • Number of Pages: XII, 300

  • Topics: Cancer Research, Pharmacology/Toxicology

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