Environment and Breast Cancer

1. Front Matter

   Pages i-xvi

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2. Epidemiologic Basis of the Role of Environmental Endocrine Disruptors in Breast Cancer

   • Robert A. Hiatt

   Pages 1-27

3. Puberty as a Window of Susceptibility

   • Frank M. Biro, Mary S. Wolff

   Pages 29-41

4. In Search of the Optimal Experimental Model

   • Irma H. Russo, Jose Russo

   Pages 43-54

5. Early Life Exposure to Bisphenol A and Breast Neoplasia

   • Maricel V. Maffini, Carlos Sonnenschein, Ana M. Soto

   Pages 55-68

6. Endocrine Disruptors Affect the Genomic Profile of the Rat Mammary Gland at Different Developmental Stages

   • Ricardo López de Cicco, Julia Santucci-Pereira, Raquel Moral, Suraj Peri, Michael Slifker, Irma H. Russo et al.

   Pages 69-101

7. Proteomic Basis for the Increased Susceptibility of the Mammary Gland to Carcinogenesis After Perinatal Exposure to Bisphenol A

   • Sarah Jenkins, Angela M. Betancourt, Jun Wang, James A. Mobley, Coral A. Lamartiniere

   Pages 103-125

8. Dioxin as an Environmental Pollutant and Its Role in Breast Cancer

   • Stephen Safe, Kelcey Walker, Shu Zhang

   Pages 127-146

9. Mammary Gland as a Sensitive Tissue to Developmental Exposures of Perfluorooctanoic Acid (PFOA) in the Mouse

   • Sally S. White, Suzanne E. Fenton, Chengfeng Yang, Sandra Z. Haslam

   Pages 147-166

10. Atrazine: An Environmental Endocrine Disruptor That Alters Mammary Gland Development and Tumor Susceptibility

    • Jennifer L. Rayner, Suzanne E. Fenton

    Pages 167-183

11. The Biological Impact of Radiation Exposure on Breast Cancer Development

    • David H. Nguyen, Irineu Illa Bochaca, Mary Helen Barcellos-Hoff

    Pages 185-203

12. Brain Estrogens and Metabolism

    • Yong Xu, Deborah J. Clegg

    Pages 205-229

13. Back Matter

    Pages 231-237

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Breast cancer is a complex disease caused by multiple environmental and lifestyle factors interacting with genetic susceptibility across the life span. Therefore, environmental factors are of intense interest to both researchers and community members, including women with breast cancer. There is not adequate literature that addresses this issue comprehensively from epidemiological, experimental, and translational research perspective. This book is aiming to fill this gap by gathering chapters from the most recognized experts in the field of breast biology and cancer with special interests in environmental issues.

• Perfluorooctanoic Acid
• atrazine
• dioxin
• ductal carcinoma
• lobular carcinoma
• mammary gland

• Lab. Breast Cancer Research, Fox Chase Cancer Center, Philadelphia, USA

  Jose Russo

Jose Russo, MD, FACP is a Professor, Senior Member, and Director of the Breast Cancer Research Laboratory and the Breast Cancer and the Environment Research Center in Philadelphia, Pennsylvania.

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