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Innate Tolerance in the CNS

Translational Neuroprotection by Pre- and Post-Conditioning

  • Book
  • © 2013

Overview

Editors:
  1. Jeffrey M. Gidday

    1. , Departments of Neurosurgery, Washington University School of Medicine, St. Louis, USA

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  2. Miguel A. Perez-Pinzon

    1. , Department of Neurology, University of Miami Miller School of Med, Miami, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. John H. Zhang

    1. Loma Linda University, Loma Linda, USA

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  • This book will be the first to summarize basic mechanisms of both pre- and post-conditioning.
  • Expand the basic science studies to date for their potential application as a clinical treatment.
  • Critically comments on the efficacy of conditioning for all stroke-related events and subtypes.

Part of the book series: Springer Series in Translational Stroke Research (SSTSR)

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Table of contents (30 chapters)

  1. Front Matter

    Pages i-ix
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  2. Comparative Physiology and Historical Background

    1. Front Matter

      Pages 1-1
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  3. Comparative Physiology and Historical Background

    1. Tolerance, Historical Review

      • Roger Simon
      Pages 3-18

    2. Anoxia Resistance in Lower and Higher Vertebrates

      • John W. Thompson, Göran E. Nilsson, Miguel A. Perez-Pinzon
      Pages 19-35

    3. Hibernation: A Natural Model of Tolerance to Cerebral Ischemia/Reperfusion

      • Kelly L. Drew, Jeffrey A. Zuckerman, Phillip E. Shenk, Lori K. Bogren, Tulasi R. Jinka, Jeanette T. Moore
      Pages 37-50

    4. Preconditioning in the Heart

      • Derek J. Hausenloy, Derek M. Yellon
      Pages 51-101

  4. Conditioning Methods

    1. Front Matter

      Pages 103-103
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    2. Neuroprotection and Physical Preconditioning: Exercise, Hypothermia, and Hyperthermia

      • Ryan Kochanski, David Dornbos III, Yuchuan Ding
      Pages 105-131

    3. A New Future in Brain Preconditioning Based on Nutraceuticals: A Focus on α-Linolenic Omega-3 Fatty Acid for Stroke Protection

      • Nicolas Blondeau, Joseph S. Tauskela
      Pages 133-163

    4. Medical Gases for Conditioning: Volatile Anesthetics, Hyperbaric Oxygen, and Hydrogen Sulfide

      • Zhiyi Zuo
      Pages 165-181

    5. Hypoxic Preconditioning in the CNS

      • Robert D. Gilchrist, Jeffrey M. Gidday
      Pages 183-212

    6. Pharmacologic Preconditioning

      • Jian Guan, Richard F. Keep, Ya Hua, Karin M. Muraszko, Guohua Xi
      Pages 213-224

    7. Surgical Methods to Induce Brain Preconditioning

      • Giuseppe Pignataro, Ornella Cuomo, Antonio Vinciguerra
      Pages 225-240

  5. Conditioning Models for Cerebral Ischemia

    1. Front Matter

      Pages 241-241
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    2. Tolerance Against Global Cerebral Ischemia: Experimental Strategies, Mechanisms, and Clinical Applications

      • Kunjan R. Dave, Hung Wen Lin, Miguel A. Perez-Pinzon
      Pages 243-257

    3. Preconditioning and Neuroprotection in the Immature Brain

      • Nicole M. Jones, Adam A. Galle
      Pages 259-268

    4. Conditioning Studies in Focal Cerebral Ischemia: Model Selection, Physiological Monitoring, and Other Methodological Issues

      • Thaddeus S. Nowak Jr., Liang Zhao
      Pages 269-289

    5. Preconditioning for SAH

      • Robert P. Ostrowski, John H. Zhang
      Pages 291-308

    6. Preconditioning and Intracerebral Hemorrhage

      • Richard F. Keep, Ya Hua, Guohua Xi
      Pages 309-316

    7. The Protective Effects of Ischemic Postconditioning in Experimental Stroke

      • Heng Zhao
      Pages 317-335
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About this book

Cerebral preconditioning is a phenomenon wherein a mild insult or stress induces cellular and tissue adaptation or tolerance to a later, severe injury, therefore reflecting the efficacy of endogenous mechanisms of cerebrovascular protection. Initially identified for rapid cardiac protection, preconditioning has expanded to all aspects of CNS protection from ischemia, trauma and potentially neurodegeneration. Many different stimuli or stressors have been identified as preconditioning agents, suggesting a downstream convergence of mechanisms and underscoring the potential for translational application of preconditioning in the clinic. Moreover, the fundamental mechanisms responsible for preconditioning-induced tolerance will help in the design novel pharmacological approaches for neuroprotection. While stroke and many other brain injuries are not predictable, in some populations (e.g., metabolic syndrome, patients undergoing carotid endarterectomy, aneurysm clipping, or with recent TIAs) the risk for stroke is identifiable and significant, and preconditioning may represent a useful strategy for neuroprotection. For unpredictable injuries, post-conditioning the brain – or inducing endogenous protective mechanisms after the initial injury – can also abrogate the extent of injury. Finally, remote pre- and post-conditioning methods have been developed in animals, and are now being tested in clinical trials, wherein a brief, noninjurious stress to a noncerebral tissue (i.e., skeletal muscle) can provide protection to the CNS and thereby allows clinicians the opportunity to circumvent concerns regarding the direct preconditioning of neurological tissues.

Editors and Affiliations

  • , Departments of Neurosurgery, Washington University School of Medicine, St. Louis, USA

    Jeffrey M. Gidday

  • , Department of Neurology, University of Miami Miller School of Med, Miami, USA

    Miguel A. Perez-Pinzon

  • Loma Linda University, Loma Linda, USA

    John H. Zhang

About the editors

Jeffrey M. Gidday PhD, Associate Professor of Neurosurgery at Washington University School of Medicine, has been working in the field of CNS preconditioning for 18 years, and has numerous publications on preconditioning-induced protection in the setting of several different cerebral and retinal pathologies. 

Miguel A. Perez-Pinzon PhD is Professor of Neurology/Neuroscience, Vice-Chair for Basic Science of Neurology at the University of Miami Miller School of Medicine. He began studies of ischemic preconditioning in 1995 and for many years prior to that worked in the field of anoxia tolerance, publishing close to 50 peer-reviewed articles and many book chapters on these topics.

John H. Zhang MD PhD is Professor of Neurosurgery, Anesthesiology, and Physiology, and Vice-Chair of the Basic Science Department at the Loma Linda University School of Medicine. His research interests include stroke and medical gases, and he has published papers related to pre-, post- and remote-conditioning in subarachnoid hemorrhage, focal cerebral ischemia, and neonatal brain injury.

Bibliographic Information

  • Book Title: Innate Tolerance in the CNS

  • Book Subtitle: Translational Neuroprotection by Pre- and Post-Conditioning

  • Editors: Jeffrey M. Gidday, Miguel A. Perez-Pinzon, John H. Zhang

  • Series Title: Springer Series in Translational Stroke Research

  • DOI: https://doi.org/10.1007/978-1-4419-9695-4

  • Publisher: Springer New York, NY

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Science+Business Media New York 2013

  • Hardcover ISBN: 978-1-4419-9694-7Published: 21 September 2012

  • Softcover ISBN: 978-1-4939-4177-3Published: 23 August 2016

  • eBook ISBN: 978-1-4419-9695-4Published: 21 September 2012

  • Series ISSN: 2363-958X

  • Series E-ISSN: 2363-9598

  • Edition Number: 1

  • Number of Pages: IX, 699

  • Topics: Neurosciences, Neurology, Neurobiology

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