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Cardiac Remodeling and Failure

  • Book
  • © 2003

Overview

Editors:
  1. Pawan K. Singal

    1. Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, Faculty of Medicine, University of Manitoba, Winnipeg, Canada

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  2. Ian M. C. Dixon

    1. Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, Faculty of Medicine, University of Manitoba, Winnipeg, Canada

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  3. Lorrie A. Kirshenbaum

    1. Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, Faculty of Medicine, University of Manitoba, Winnipeg, Canada

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  4. Naranjan S. Dhalla

    1. Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, Faculty of Medicine, University of Manitoba, Winnipeg, Canada

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Part of the book series: Progress in Experimental Cardiology (PREC, volume 5)

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Table of contents (35 chapters)

  1. Front Matter

    Pages i-xvi
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  2. Heart Failure and Therapies

    1. Front Matter

      Pages 1-1
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    2. Pathophysiology of Heart Failure: Role of Oxygen Free Radicals

      • Jawahar Kalra
      Pages 3-16

    3. Therapeutics in Congestive Heart Failure: From Hemodynamics to Neurohormones

      • Steven R. Goldsmith
      Pages 17-34

    4. Dilated Cardiomyopathies and Congestive Heart Failure

      • Bernhard Maisch, Arsen D. Ristić, Rainer Funck, Peter Alter, Susanne Kölsch, Annette Richter et al.
      Pages 35-65

    5. The Failing SHHF Rat Heart

      • Ruth A. Altschuld, Bethany J. Holycross, M. Judith Radin, Sylvia A. McCune
      Pages 67-74

    6. Increased expression of Na+−Ca2+ exchanger in the myocardium. Impact on contractility and arrhythmogenesis in heart failure

      • Wolfgang Schillinger, Gerd Hasenfuss
      Pages 75-86

    7. Sarcoplasmic Reticulum Proteins as Potential Targets for Gene Therapy of Heart Failure

      • Jos M. J. Lamers, Karin Eizema, Karel Bezstarosti, Henry Fechner, Sonja Schneider-Rasp, Haili Wang et al.
      Pages 87-101

    8. Sarcoplasmic Reticulum Gene Expression of Ca2+-Cycling Proteins as a Target for the Treatment of Heart Failure

      • Thomas Netticadan, Rana M. Temsah, Naranjan S. Dhalla
      Pages 103-121

    9. Effects of the Beta-Adrenoceptor Blocker Carvedilol in Children with Myocardial Failure

      • Hasso Scholz, Stephanie Läer, Frederike Behn, Michele Eiselt, Thomas S. Mir, Jochen Weil
      Pages 123-133

    10. The Contractile and Neurohormonal Roles of Phospholamban in Heart Failure

      • Rajesh Dash, Evangelia G. Kranias
      Pages 135-152

    11. Annexins: Roles in the Regulation of Ca2+ Handling Proteins During Heart Failure

      • Emmanuel Camors, Ioulia Belikova, Virginie Monceau, Danièle Charlemagne
      Pages 153-163

    12. Modulators of Myofibrillar Function: Implications in Myocardial Failure

      • Peter VanBuren, Mark Hünlich, David Fishbaugher, Teuro Noguchi
      Pages 165-179

  3. Remodeling and Heart Failure

    1. Front Matter

      Pages 181-181
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    2. Structural Remodeling of Cardiac Myocytes in Hypertrophy and Progression to Failure

      • A Martin Gerdes, Xuejun Wang
      Pages 183-193

    3. Three-Dimensional Imaging of Microvascular Morphology and Remodeling in Acute and Chronic Myocarditis

      • Atushi Takeda, Yasuyuki Tanaka, Chihiro Shikata, Nobuakira Takeda
      Pages 195-203

    4. Alterations in Hemodynamic and Neurohumoral Responses to Exercise in Swine with Left Ventricular Remodeling Early after Myocardial Infarction: Role of Blunted NO Bioavailability

      • David B. Haitsma, Daphne Merkus, Daneel Bac, Frans Boomsma, Pieter D. Verdouw, Dirk J. Duncker
      Pages 205-230

    5. Sheep Models of Postinfarction Left Ventricular Remodeling

      • L. Henry Edmunds Jr, Joseph H. Gorman III, Robert C. Gorman
      Pages 231-243

    6. Echocardiographic Characterization of the Cardiovascular Phenotype in Mouse Models

      • Brian D. Hoit
      Pages 245-258

    7. A Novel Role for Cytokine Signaling in Cardiac Remodeling

      • Keiko Yamauchi-Takihara, Hisao Hirota, Yasushi Fujio, Masahiro Izumi, Yuichi Oshima, Yoshikazu Nakaoka
      Pages 259-264
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Keywords

About this book

According to the World Health Report (2000 http:/ /www. who. int/whr), of the 55 million deaths worldwide in 1999, more than 16 million were secondary to car­ diovascular complications. With the prospect of world population increasing from the current level of 6 billion to 9 billion by the middle of this century, the burden of cardiac disease is going to increase astronomically. Furthermore, scientists are being challenged not only to reduce mortality, but also to improve quality of life. Thus, more than ever, intellectuals from different disciplines including biology, sociology, informatics and health care have to join forces to meet the mandate. The World Heart Congress with a focus on "Frontiers in Cardiovascular Health" held in Winnipeg during July 6-11, 2001, made a unique attempt to bring these specialists together to brainstorm and map out the course of action for cardiovascular research and health in the next century. Anytime there is a relative increase in the workload on the heart, there are adap­ tive myocardial as well as humoral responses. When these adaptations or remodel­ ing at the organ, subcellular or gene level, become inadequate for a proper tissue perfusion, the condition of heart failure ensues. Prevention of the factors leading to the relative increase in workload as well as a better understanding of the adap­ tive responses and their failure are some of the hopes to combat the morbidity and mortality due to heart failure.

Editors and Affiliations

  • Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Pawan K. Singal, Ian M. C. Dixon, Lorrie A. Kirshenbaum, Naranjan S. Dhalla

Bibliographic Information

  • Book Title: Cardiac Remodeling and Failure

  • Editors: Pawan K. Singal, Ian M. C. Dixon, Lorrie A. Kirshenbaum, Naranjan S. Dhalla

  • Series Title: Progress in Experimental Cardiology

  • DOI: https://doi.org/10.1007/978-1-4419-9262-8

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2003

  • Hardcover ISBN: 978-1-4020-7177-5Published: 28 February 2003

  • Softcover ISBN: 978-1-4613-4864-1Published: 13 October 2012

  • eBook ISBN: 978-1-4419-9262-8Published: 06 December 2012

  • Series ISSN: 1389-1774

  • Edition Number: 1

  • Number of Pages: XVI, 545

  • Topics: Cardiology

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