Calreticulin

1. Front Matter

   Pages i-xx

   PDF

2. Introduction to Calreticulin

   • Paul Eggleton, Marek Michalak

   Pages 1-8

3. Biochemical and Molecular Properties of Calreticulin

   • Steven J. Johnson, Kjell O. Håkansson

   Pages 9-18

4. A Chaperone System for Glycoprotein Folding: The Calnexin/Calreticulin Cycle

   • Lars Ellgaard, Ari Helenius

   Pages 19-29

5. Calnexin, an ER Integral Membrane Chaperone in Health and Disease

   • John J. M. Bergeron, David Y. Thomas

   Pages 30-37

6. Sub-Cellular Distribution of Calreticulin

   • Sylvia Papp, Michal Opas

   Pages 38-48

7. Calnexin and Calreticulin, Molecular Chaperones of the Endoplasmic Reticulum

   • Michael R. Leach, David B. Williams

   Pages 49-62

8. Roles of Calreticulin and Calnexin in Myeloperoxidase Synthesis

   • William M. Nauseef

   Pages 63-74

9. Calreticulin-Mediated Nuclear Protein Export

   • Ben E. Black, Bryce M. Paschal

   Pages 75-84

10. The Role of Calnexin and Calreticulin in MHC Class I Assembly

    • Raju Adhikari, Tim Elliott

    Pages 85-93

11. Calreticulin and the Endoplasmic Reticulum in Plant Cell Biology

    • Paola Mariani, Lorella Navazio, Anna Zuppini

    Pages 94-104

12. Modulation of Calcium Homeostasis by the Endoplasmic Reticulum in Health and Disease

    • György Szabadkai, Mounia Chami, Paolo Pinton, Rosario Rizzuto

    Pages 105-125

13. Calnexin and Calreticulin, ER Associated Modulators of Calcium Transport in the ER

    • Patricia Camacho, Linu John, Yun Li, R. Madelaine Paredes, H. Llewelyn Roderick

    Pages 126-132

14. ER Calcium and ER Chaperones: New Players in Apoptosis?

    • Nicolas Demaurex, Maud Frieden, Serge Arnaudeau

    Pages 133-141

15. Calreticulin in Cytotoxic Lymphocyte-Mediated Cytotoxicity

    • Dorothy Hudig, Reza Karimi

    Pages 142-150

16. A Role for Calreticulin in the Clearance of Apoptotic Cells and in the Innate Immune System

    • Peter M. Henson

    Pages 151-161

17. Calreticulin and Tumor Suppression

    • Giovanna Tosato, Lei Yao, Sandra E. Pike

    Pages 162-179

18. Calreticulin’s Role(s) in Autoimmune Disorders

    • Richard D. Sontheimer, Doina Racila, Emil Racila, Paul Eggleton, Suzanne Donnelly

    Pages 180-192

19. Cell Surface Calreticulin: Role in Signaling Thrombospondin Anti-Adhesive Activity

    • Silvia M. Goicoechea, J. E. Murphy-Ullrich

    Pages 193-204

20. Calreticulin Regulation of Lung Endothelial NOS Activity

    • Jawaharlal M. Patel, Jianliang Zhang, Yong D. Li, Edward R. Block

    Pages 205-219

The book focuses on the latest discoveries on calreticulin, calnexin and other endoplasmic reticulum proteins. Calreticulin has been implicated to affect diverse cellular function and play a role in many pathologies including protein folding disorders, cardiac pathologies, cancer and autoimmunity. This book contains contributions from the world leaders in the area of endoplasmic reticulum function, protein folding, Calcium homeostasis and autoimmunity. It raises many intriguing questions about calreticulin, calnexin and the endoplasmic reticulum and gives a unique opportunity to realize the significance of these calcium-binding chaperones. The book is unique in every respect and we are not aware of any other publication focusing on these aspects of endoplasmic reticulum biology. Because of a central role of endoplasmic reticulum, calreticulin and calnexin in virtually all cellular functions, the book should be of interest to everyone in the biological sciences.

• Calcium
• cells
• endothelium
• physiology
• proteins

• Peninsula Medical School, Devon, U.K. MRC Immunochemistry Unit Department of Biochemistry, University of Oxford, Oxford, UK

  Paul Eggleton

• CIHR Membrane Protein Research Group Department of Biochemistry, University of Alberta Edmonton, Alberta, Canada

  Marek Michalak

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