A Molecular and Cellular View of Protein Kinase CK2

1. Front Matter

   Pages i-2

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2. CK2, a protein kinase of the next millennium

   • Grazyna Dobrowolska, Fred J. Lozeman, Dongxia Li, Edwin G. Krebs

   Pages 3-12

3. A multifunctional network of basic residues confers unique properties to protein kinase CK2

   • Stefania Sarno, Philippe Vaglio, Luca Cesaro, Oriano Marin, Lorenzo A. Pinna

   Pages 13-19

4. Intermolecular contact sites in protein kinase CK2

   • Andreas Krehan, Walter Pyerin

   Pages 21-28

5. Binding of polylysine to protein kinase CK2, measured by Surface Plasmon Resonance

   • Maria J. Benitez, Gerardo Mier, Fernando Brione, Francisco J. Moreno, Juan S. Jiménez

   Pages 29-33

6. Functional analysis of CK2β-derived synthetic fragments

   • Flavio Meggio, Oriano Marin, Stefania Sarno, Lorenzo A. Pinna

   Pages 35-42

7. Dissecting subdomains involved in multiple functions of the CK2β subunit

   • Didier Leroy, Odile Filhol, Nora Quintaine, Denis Sarrouilhe, Petra Loue-Mackenbach, Edmond M. Chambaz et al.

   Pages 43-50

8. Interactions of protein kinase CK2β subunit within the holoenzyme and with other proteins

   • Mette Kusk, Rehana Ahmed, Bo Thomsen, Christian Bendixen, Olaf-Georg Issinger, Brigitte Boldyreff

   Pages 51-58

9. CK2α loci in the human genome: Structure and transcriptional activity

   • Ute Wirkner, Walter Pyerin

   Pages 59-64

10. Murine protein kinase CK2: Gene and oncogene

    • Xin Xu, Esther Landesman-Bollag, Padma L. Channavajhala, David C. Seldin

    Pages 65-74

11. Interactions of protein kinase CK2 subunits

    • Iris Korn, Silvio Gutkind, N. Srinivasan, Tom L. Blundell, Catherine C. Allende, Jorge E. Allende

    Pages 75-83

12. Mutations in the C-terminal domain of topoisomerase II affect meiotic function and interaction with the casein kinase 2 β subunit

    • D. Leroy, G. C. Alghisi, E. Roberts, O. Filhol-Cochet, S. M. Gasser

    Pages 85-95

13. Association of protein kinase CK2 with eukaryotic translation initiation factor eIF-2 and with grp94/endoplasmin

    • Marta Riera, Nerea Roher, Francesc Miró, Carles Gil, Ramon Trujillo, José Aguilera et al.

    Pages 97-104

14. Searching interaction partners of protein kinase CK2β subunit by two-hybrid screening

    • Swen Grein, Karine Raymond, Claude Cochet, Walter Pyerin, Edmond M. Chambaz, Odile Filhol

    Pages 105-109

15. Protein kinase CK2 interacts with a multi-protein binding domain of p53

    • Claudia Götz, Petra Scholtes, Alexandra Prowald, Norbert Schuster, Wolfgang Nastainczyk, Mathias Montenarh

    Pages 111-120

16. BTF3 is a potential new substrate of protein kinase CK2

    • Swen Grein, Walter Pyerin

    Pages 121-128

17. Protein kinase CK2α may induce gene expression but unlikely acts directly as a DNA-binding transcription-activating factor

    • Karin Ackermann, Walter Pyerin

    Pages 129-134

18. Role of protein kinase CK2 in phosphorylation of nucleosomal proteins in relation to transcriptional activity

    • Chuanhai Guo, Alan T. Davis, Shihui Yu, Sherif Tawfic, Khalil Ahmed

    Pages 135-142

19. A review of progress towards elucidating the role of protein kinase CK2 in polymerase III transcription: Regulation of the TATA binding protein

    • Ataollah Ghavidel, Darren J. Hockman, Michael C. Schultz

    Pages 143-148

20. The binding of the α subunit of protein kinase CK2 and RAP74 subunit of TFIIF to protein-coding genes in living cells is DRB sensitive

    • E. Egyházi, A. Ossoinak, O. Filhol-Cochet, C. Cochet, A. Pigon

    Pages 149-159

It is now generally recognized that protein kinase signaling is involved in virtually every aspect of cell function, including growth and proliferation. The field of protein phosphorylation, including the enzymes involved in this post-translational modification, continues to advance at a fascinating pace.
Since the first international meeting on this topic, held in Heidelberg in 1994, several new avenues of CK2 research have emerged despite persistent deficiencies in our understanding of the regulation of its activity. Among the significant new directions are studies related to the structure of the enzyme, especially its crystal structure, as well as an interesting aspect of CK2 function that involves its subunits as binding partners of several other proteins. In addition, new data have been gathered on the role of CK2 in transcription as well as in certain other cellular functions. To address these various aspects of the progress of CK2, a number of key scientists from different parts of the world came together at the second international meeting on `A Molecular and Cellular View of Protein Kinase CK2', held at Villard de Lans near Grenoble on September 24-26, 1997. The meeting was attended by nearly 50 participants and included 28 presentations, which provide a view of the latest progress on protein kinase CK2.

• enzyme
• enzymes
• mutation
• oncogene
• phosphorylation
• protein
• proteins
• transcription
• translation

• Cellular and Molecular Biochemistry, Research Laboratory (151) V.A. Medical Centre, Minneapolis, USA

  Khalil Ahmed

• Biokemisk Institut, Odense Universitet, Odense M, Denmark

  O. G. Issinger

• Laboratoire de Biochemie des Regulations Cellulaires Endocrines, INSERM U244 DBMS, CEA Grenoble, Grenoble Cedex 9, France

  E. Chambaz

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