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Mechanobiology of Cell-Cell and Cell-Matrix Interactions

  • Book
  • © 2011

Overview

Editors:
  1. A. Wagoner Johnson

    1. , Department of Mechanical & Industrial, University of Illinois, Urbana-Champaign, Urbana, USA

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  2. Brendan A.C. Harley

    1. , Department of Chemical & Biomolecular, University of Illinois, Urbana-Champaign, Urbana, USA

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  • Provides an examination of the mechanobiology of cell-matrix interactions

  • Discusses the emerging area of cooperative behavior of cells, as well as current methods for probing cell mechanics

  • Explores the mechano-pathology of cancer and disease

  • Includes supplementary material: sn.pub/extras

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Responses of Cells to Adhesion-Mediated Signals: A Universal Mechanism

    • Andrew D. Rape, Wei-Hui Guo, Yu-Li Wang
    Pages 1-10

  3. Substrate Elasticity as a Probe to Measure Mechanosensing at Cell-Cell and Cell-Matrix Junctions

    • Jessamine P. Winer, Anant Chopra, J. Yasha Kresh, Paul A. Janmey
    Pages 11-22

  4. A Role for Integrin-ECM Bonds as Mechanotransducers that Modulate Adult Stem Cell Fate

    • Nathaniel Huebsch, David J. Mooney
    Pages 23-46

  5. Cell-Generated Forces in Tissue Assembly, Function, and Disease

    • John Huynh, Joseph P. Califano, Cynthia A. Reinhart-King
    Pages 47-74

  6. Cell-Cell Interactions and the Mechanics of Cells and Tissues Observed in Bioartificial Tissue Constructs

    • Guy M. Genin, Teresa M. Abney, Tetsuro Wakatsuki, Elliot L. Elson
    Pages 75-103

  7. Specific and Non-Specific Adhesion in Cancer Cells with Various Metastatic Potentials

    • Xin Tang, Tony Cappa, Theresa Kuhlenschmidt, Mark Kuhlenschmidt, Taher Saif
    Pages 105-122

  8. Systems Biology of Tumor Cell Migration in 3D: Protein Signaling

    • Jaya Srivastava, Muhammad H. Zaman
    Pages 123-149

  9. Development of Three-Dimensional Tumor Models for the Study of Anti-Cancer Drug Effects

    • Wei Sun, Raj Rajagopalan, Chwee Teck Lim
    Pages 151-168

  10. Mechanobiology of Epidermal Keratinocytes: Desmosomes, Hemidesmosomes, Keratin Intermediate Filaments, and Blistering Skin Diseases

    • John C. Selby
    Pages 169-210

  11. Quantifying Cell-Matrix Deformations in Three Dimensions

    • Christian Franck, Stacey A. Maskarinec
    Pages 211-232

  12. Tools for Studying Biomechanical Interactions in Cells

    • Rebecca E. Taylor, Vikram Mukundan, Beth L. Pruitt
    Pages 233-265

  13. Biomaterials for Studies in Cellular Mechanotransduction

    • Ross De Volder, Hyunjoon Kong
    Pages 267-277

  14. Optical Sensing of Red Blood Cell Dynamics

    • YongKeun Park, Catherine A. Best, Gabriel Popescu
    Pages 279-309

  15. Back Matter

    Pages 311-319
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Keywords

About this book

Mechanobiology of Cell-Matrix Interactions focuses on characterization and modeling of interactions between cells and their local extracellular environment, exploring how these interactions may mediate cell behavior. Studies of cell-matrix interactions rely on integrating engineering, (molecular and cellular) biology, and imaging disciplines. Recent advances in the field have begun to unravel our understanding of how cells gather information from their surrounding environment, and how they interrogate such information during the cell fate decision making process. Topics include adhesive and integrin-ligand interactions; extracellular influences on cell biology and behavior; cooperative mechanisms of cell-cell and cell-matrix interactions; the mechanobiology of pathological processes; (multi-scale) modeling approaches to describe the complexity or cell-matrix interactions; and quantitative methods required for such experimental and modeling studies.

Editors and Affiliations

  • , Department of Mechanical & Industrial, University of Illinois, Urbana-Champaign, Urbana, USA

    A. Wagoner Johnson

  • , Department of Chemical & Biomolecular, University of Illinois, Urbana-Champaign, Urbana, USA

    Brendan A.C. Harley

Bibliographic Information

  • Book Title: Mechanobiology of Cell-Cell and Cell-Matrix Interactions

  • Editors: A. Wagoner Johnson, Brendan A.C. Harley

  • DOI: https://doi.org/10.1007/978-1-4419-8083-0

  • Publisher: Springer New York, NY

  • eBook Packages: Engineering, Engineering (R0)

  • Copyright Information: Springer Science+Business Media, LLC 2011

  • Hardcover ISBN: 978-1-4419-8082-3Published: 03 March 2011

  • Softcover ISBN: 978-1-4899-7379-5Published: 21 November 2014

  • eBook ISBN: 978-1-4419-8083-0Published: 21 February 2011

  • Edition Number: 1

  • Number of Pages: XIII, 319

  • Topics: Biomedical Engineering and Bioengineering, Biological and Medical Physics, Biophysics, Cell Biology

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