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Targeting the Wnt Pathway in Cancer

  • Book
  • © 2011

Overview

Editors:
  1. Kathleen H. Goss

    1. Medical Center, Dept. Surgery, University of Chicago, Chicago, USA

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  2. Michael Kahn

    1. Eli & Edythe Broad Center for, Regenerative Medicine &, University of Southern California, Los Angeles, USA

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    You can also search for this editor in PubMed   Google Scholar

  • Provides an overview of the Wnt pathway as a therapeutic target for cancer

  • Discusses the preclinical development of inhibitors specifically directed to upstream and downstream components of the pathway

  • In-depth look at the Wnt pathway by recognized leaders in the field

  • Includes supplementary material: sn.pub/extras

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-xi
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  2. An Introduction to Wnt Signaling

    • Paul Polakis
    Pages 1-18

  3. Regulation of Wnt Secretion and Distribution

    • Xiaofang Tang, Xiaolan Fan, Xinhua Lin
    Pages 19-33

  4. Wnt Signaling in Stem Cells

    • Philipp C. Manegold, Jia-Ling Teo, Michael Kahn
    Pages 35-50

  5. Crosstalk of the Wnt Signaling Pathway

    • Michael Thompson, Kari Nejak-Bowen, Satdarshan P. S. Monga
    Pages 51-80

  6. Dysregulation of the Wnt Pathway in Solid Tumors

    • Jenifer R. Prosperi, Hue H. Luu, Kathleen H. Goss
    Pages 81-128

  7. WNT/β-Catenin Signaling in Leukemia

    • Markus Müschen
    Pages 129-142

  8. Use of Genetically Engineered Mouse Models in Identification and Validation of Therapeutic Targets for Colon Cancer

    • Masahiro Aoki, Makoto Mark Taketo
    Pages 143-163

  9. Targeting Wnt Signalling in Cancer

    • Aliaksei Holik, Alan R. Clarke
    Pages 165-182

  10. Inhibiting the Wnt Signaling Pathway with Small Molecules

    • Ho-Jin Lee, Xinxin Zhang, Jie J. Zheng
    Pages 183-209

  11. Targeting of Wnt Signaling Inside the Nucleus

    • Miki Shitashige, Tesshi Yamada
    Pages 211-225

  12. Back Matter

    Pages 227-240
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Keywords

About this book

Inappropriate activation of the Wnt signaling pathway is observed in many human cancers and is sufficient to drive tumor initiation and progression in numerous contexts. Multiple mechanisms, such as overexpression of Wnt ligands, inactivation of the APC and Axin tumor suppressors, and mutation of -catenin, are responsible for pathway activation in tumor cells. The development of potent Wnt pathway antagonists for therapeutic use has been a major effort for investigators in both academia and industry in recent years. This book will provide an overview of the Wnt pathway as a therapeutic target for cancer, and discuss the preclinical development of inhibitors specifically directed to upstream and downstream components of the pathway.

Editors and Affiliations

  • Medical Center, Dept. Surgery, University of Chicago, Chicago, USA

    Kathleen H. Goss

  • Eli & Edythe Broad Center for, Regenerative Medicine &, University of Southern California, Los Angeles, USA

    Michael Kahn

Bibliographic Information

  • Book Title: Targeting the Wnt Pathway in Cancer

  • Editors: Kathleen H. Goss, Michael Kahn

  • DOI: https://doi.org/10.1007/978-1-4419-8023-6

  • Publisher: Springer New York, NY

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Science+Business Media, LLC 2011

  • Hardcover ISBN: 978-1-4419-8022-9Published: 28 January 2011

  • Softcover ISBN: 978-1-4899-8164-6Published: 13 October 2014

  • eBook ISBN: 978-1-4419-8023-6Published: 25 January 2011

  • Edition Number: 1

  • Number of Pages: XI, 240

  • Topics: Oncology, Pharmacology/Toxicology, Cancer Research

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