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Pharmaco-Complexity

Non-Linear Phenomena and Drug Product Development

  • Book
  • © 2011

Overview

Authors:
  1. Anthony J. Hickey

    1. Eshelman School of Pharmacy, Division of Molecular Pharmaceutics, University of North Carolina, Chapel Hill, USA

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  2. Hugh D.C. Smyth

    1. , Pharmaceutics Division - PHR 4.214, University of Texas, Austin, USA

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  • Describes topics that indicate a need for a non-linear interpretation if they are to be characterized accurately, understood fully and potentially controlled or modulated in the service of improved therapeutic strategies
  • Promotes discussion of phenomena leading to pharmacological effect and the complex interactions ultimately resulting in improved disease control and health maintenance
  • Includes supplementary material: sn.pub/extras

Part of the book series: Outlines in Pharmaceutical Sciences (OIPS, volume 1)

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Table of contents (7 chapters)

  1. Front Matter

    Pages i-viii
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  2. The Nature of Complexity and Relevance to Pharmaceutical Sciences

    • Anthony J. Hickey, Hugh D. C. Smyth
    Pages 1-4

  3. Phenomena in Physical and Surface Chemistry

    • Anthony J. Hickey, Hugh D. C. Smyth
    Pages 5-18

  4. Solid State Pharmaceuticals: Solving Complex Problems in Preformulation and Formulation

    • Anthony J. Hickey, Hugh D. C. Smyth
    Pages 19-36

  5. Considerations in Monitoring and Controlling Pharmaceutical Manufacturing

    • Anthony J. Hickey, Hugh D. C. Smyth
    Pages 37-45

  6. Pharmacokinetics and Pharmacodynamics

    • Anthony J. Hickey, Hugh D. C. Smyth
    Pages 47-54

  7. Impact of Complexity on Population Biology

    • Anthony J. Hickey, Hugh D. C. Smyth
    Pages 55-59

  8. Conclusion

    • Anthony J. Hickey, Hugh D. C. Smyth
    Pages 61-66

  9. Back Matter

    Pages 67-71
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Keywords

About this book

The historical approach to the interpretation of physical, chemical and biological phenomena has been to consider relationships with causative factors that can be reduced to linearity allowing simple and direct interpretation. However, it is increasingly evident that there is often more information in the data than linear interpretations allow. The current capacity for computers to assist in identifying non-linear relationships allows greater interpretation of data which illuminates the phenomena allowing the information to be translated into knowledge that can be used wisely to promote various desirable pharmaceutical outcomes. This short volume is intended to stimulate the reader to contemplate research and development areas in which the data might be more accurately interpreted to allow greater understanding and ultimately control of the pharmaceutically complex phenomena.

Authors and Affiliations

  • Eshelman School of Pharmacy, Division of Molecular Pharmaceutics, University of North Carolina, Chapel Hill, USA

    Anthony J. Hickey

  • , Pharmaceutics Division - PHR 4.214, University of Texas, Austin, USA

    Hugh D.C. Smyth

About the authors

Dr. Anthony Hickey is Professor of Molecular Pharmaceutics and Biomedical Engineering at the University of North Carolina at Chapel Hill. He is a fellow of the Institute of Biology, American Association of Pharmaceutical Scientists and the American Association for the Advancement of Science. He has published several edited and authored volumes in the fields of pharmaceutical aerosols, process engineering and particulate science.

Dr. Hugh Smyth is Assistant Professor of Pharmaceutics at the University of Texas, Austin. He is a recipient of the Young Investigator in Pharmaceutics and Pharmaceutical Technology Award of the American Association of Pharmaceutical Scientists and has edited a volume on pulmonary drug delivery. Drs. Hickey and Smyth share a research interest in the delivery of drugs to the lungs for the treatment and prevention of a number of diseases.

Bibliographic Information

  • Book Title: Pharmaco-Complexity

  • Book Subtitle: Non-Linear Phenomena and Drug Product Development

  • Authors: Anthony J. Hickey, Hugh D.C. Smyth

  • Series Title: Outlines in Pharmaceutical Sciences

  • DOI: https://doi.org/10.1007/978-1-4419-7856-1

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: American Association of Pharmaceutical Sientists 2011

  • Softcover ISBN: 978-1-4419-7855-4Published: 20 December 2010

  • eBook ISBN: 978-1-4419-7856-1Published: 15 December 2010

  • Series ISSN: 2191-3188

  • Series E-ISSN: 2191-3196

  • Edition Number: 1

  • Number of Pages: VIII, 71

  • Number of Illustrations: 7 b/w illustrations, 2 illustrations in colour

  • Topics: Pharmacology/Toxicology, Biotechnology, Biochemistry, general

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