Overview
- Prize-awarded thesis
- New research in an emerging field
- Interdisciplinary applications
- Includes supplementary material: sn.pub/extras
Part of the book series: Springer Theses (Springer Theses)
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Table of contents (5 chapters)
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Front Matter
Keywords
About this book
Proteins act as macromolecular machinery that mediate many diverse biological processes - the molecular mechanisms of this machinery has fascinated biologists for decades. Analysis of the kinetic and thermodynamic features of these mechanisms could reveal unprecedented aspects of how the machinery function and will eventually lead to a novel understanding of various biological processes. This dissertation comprehensively demonstrates how two universally conserved guanosine triphosphatases in the signal recognition particle and its membrane receptor maintain the efficiency and fidelity of the co-translational protein targeting process essential to all cells. A series of quantitative experiments reveal that the highly ordered and coordinated conformational states of the machinery are the key to their regulatory function. This dissertation also offers a mechanistic view of another fascinating system in which multistate protein machinery closely control critical biological processes.
Written while completing graduate work at California Institute of Technology.
Authors and Affiliations
About the author
Bibliographic Information
Book Title: Multistate GTPase Control Co-translational Protein Targeting
Authors: Xin Zhang
Series Title: Springer Theses
DOI: https://doi.org/10.1007/978-1-4419-7808-0
Publisher: Springer New York, NY
eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)
Copyright Information: Springer Science+Business Media, LLC 2012
Hardcover ISBN: 978-1-4419-7807-3Published: 28 September 2011
Softcover ISBN: 978-1-4899-7808-0Published: 23 August 2016
eBook ISBN: 978-1-4419-7808-0Published: 29 September 2011
Series ISSN: 2190-5053
Series E-ISSN: 2190-5061
Edition Number: 1
Number of Pages: VII, 96
Topics: Bioorganic Chemistry, Proteomics, Analytical Chemistry, Biochemistry, general