Overview
This work summarizes the contribution that insertional mutagenesis has made to our understanding of cancer
A variety of insertional mutagens are presented that have been used to study a variety of tumor types in several model organisms
The impact of insertional mutagenesis in several gene therapy trials is discussed along with strategies to avoid such complications in future clinical trials
Includes supplementary material: sn.pub/extras
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Table of contents (7 chapters)
Keywords
About this book
Editors and Affiliations
About the editors
Adam Dupuy, Ph.D., is an Assistant Professor at the Carver College of Medicine at the University of Iowa, and a rising star in the field of insertional mutagenesis; two of the last of his publications have been in Nature, and he was the lead author on one of these. Dr. Dupuy earned his B.A. at Central College in Pella, Iowar, went on to earn his Ph.D. at the University of Minnesota in the Program in Molecular, Cellular, Developmental Biology & Genetics, and did his Postdoctoral fellowship in the Mouse Cancer Genetics Program at the NCI-Frederick.
Bibliographic Information
Book Title: Insertional Mutagenesis Strategies in Cancer Genetics
Editors: Adam J. Dupuy, David A. Largaespada
DOI: https://doi.org/10.1007/978-1-4419-7656-7
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Science+Business Media, LLC 2011
Hardcover ISBN: 978-1-4419-7655-0Published: 19 November 2010
Softcover ISBN: 978-1-4899-8134-9Published: 07 October 2014
eBook ISBN: 978-1-4419-7656-7Published: 18 November 2010
Edition Number: 1
Number of Pages: VIII, 200
Topics: Cancer Research, Human Genetics, Pharmacology/Toxicology