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Insertional Mutagenesis Strategies in Cancer Genetics

  • Book
  • © 2011

Overview

Editors:
  1. Adam J. Dupuy

    1. Carver College of Medicine, Dept. Anatomy & Cell Biology, University of Iowa, Iowa City, USA

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  2. David A. Largaespada

    1. Dept. Genetics, Cell Biology &, Development, University of Minnesota, Minneapolis, USA

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  • This work summarizes the contribution that insertional mutagenesis has made to our understanding of cancer

  • A variety of insertional mutagens are presented that have been used to study a variety of tumor types in several model organisms

  • The impact of insertional mutagenesis in several gene therapy trials is discussed along with strategies to avoid such complications in future clinical trials

  • Includes supplementary material: sn.pub/extras

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Table of contents (7 chapters)

  1. Front Matter

    Pages i-viii
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  2. Insertional Mutagenesis: A Powerful Tool in Cancer Research

    • Anton Berns
    Pages 1-18

  3. Retroviral Insertional Mutagenesis in Mouse Models of Leukemia and Lymphoma

    • David A. Largaespada
    Pages 19-38

  4. Gene Discovery by MMTV Mediated Insertional Mutagenesis

    • Annabel Vendel-Zwaagstra, John Hilkens
    Pages 39-75

  5. Chicken Models of Retroviral Insertional Mutagenesis

    • Vladimír Pečenka, Petr Pajer, Vít Karafiát, Michal Dvořák
    Pages 77-112

  6. Sleeping Beauty Models of Cancer

    • Jesse D. Riordan, Laura M. Rogers, Katherine E. Berquam-Vrieze, Adam J. Dupuy
    Pages 113-130

  7. Insertional Mutagenesis in Hematopoietic Cells: Lessons Learned from Adverse Events in Clinical Gene Therapy Trials

    • Lars U. Müller, Michael D. Milsom, David A. Williams
    Pages 131-165

  8. Bioinformatics of High-Throughput Insertional Mutagenesis

    • Keiko Akagi, Ming Yi, Jean Roayaei, Robert M. Stephens
    Pages 167-188

  9. Back Matter

    Pages 189-200
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Keywords

About this book

The goal of this work is summarize the contribution that insertional mutagenesis has made to our understanding of cancer. A variety of insertional mutagens are presented that have been used to study a variety of tumor types in several model organisms. In addition, the impact of insertional mutagenesis in several gene therapy trials is discussed along with strategies to avoid such complications in future clinical trials.

Editors and Affiliations

  • Carver College of Medicine, Dept. Anatomy & Cell Biology, University of Iowa, Iowa City, USA

    Adam J. Dupuy

  • Dept. Genetics, Cell Biology &, Development, University of Minnesota, Minneapolis, USA

    David A. Largaespada

About the editors

Adam Dupuy, Ph.D., is an Assistant Professor at the Carver College of Medicine at the University of Iowa, and a rising star in the field of insertional mutagenesis; two of the last of his publications have been in Nature, and he was the lead author on one of these. Dr. Dupuy earned his B.A. at Central College in Pella, Iowar, went on to earn his Ph.D. at the University of Minnesota in the Program in Molecular, Cellular, Developmental Biology & Genetics, and did his Postdoctoral fellowship in the Mouse Cancer Genetics Program at the NCI-Frederick.

Bibliographic Information

  • Book Title: Insertional Mutagenesis Strategies in Cancer Genetics

  • Editors: Adam J. Dupuy, David A. Largaespada

  • DOI: https://doi.org/10.1007/978-1-4419-7656-7

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media, LLC 2011

  • Hardcover ISBN: 978-1-4419-7655-0Published: 19 November 2010

  • Softcover ISBN: 978-1-4899-8134-9Published: 07 October 2014

  • eBook ISBN: 978-1-4419-7656-7Published: 18 November 2010

  • Edition Number: 1

  • Number of Pages: VIII, 200

  • Topics: Cancer Research, Human Genetics, Pharmacology/Toxicology

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