Immunologic Signatures of Rejection

1. Front Matter

   Pages i-vii

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2. Preamble

   1. Front Matter

      Pages 1-1

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   2. From the “Delayed Allergy Reaction” to the “Immunologic Constant of Rejection”

      • Ena Wang, Francesco M. Marincola

      Pages 3-8

3. The Immune Biology of Rejection: Basic Principles

   1. Front Matter

      Pages 9-9

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   2. The Yin Yang of Cancer Related Inflammation

      • Alberto Mantovani, Cecilia Garlanda, Paola Allavena, Antonio Sica, Massimo Locati

      Pages 11-16

   3. The Immune Rejection: Lessons from Experimental Models

      • Anil Shanker

      Pages 17-25

   4. Turning on and off the Immunological Switch: Immune Response Polarization and Its Control by IL-10 and STAT3

      • C. Andrew Stewart, Giorgio Trinchieri

      Pages 27-55

   5. The Angiogenic Switch: Role of Immune Cells

      • Douglas M. Noonan, Agostina Ventura, Antonino Bruno, Arianna Pagani, Adriana Albini

      Pages 57-75

   6. Chemokines and Cytotoxic Effector Molecules in Rejection

      • Alan M. Krensky, Carol Clayberger

      Pages 77-92

   7. Clinical Applications of Activated Immune Cells

      • Luciano Castiello, Marianna Sabatino, Ping Jin, Francesco M. Marincola, David Stroncek

      Pages 93-102

4. Circulating Patterns Associated with Chronic and Acute Immune Pathology

   1. Front Matter

      Pages 103-103

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   2. Blood Transcriptional Fingerprints to Assess the Immune Status of Human Subjects

      • Damien Chaussabel, Nicole Baldwin, Derek Blankenship, Charles Quinn, Esperanza Anguiano, Octavio Ramilo et al.

      Pages 105-125

   3. Innate Signatures of Immune Mediated Resolution and Persistence of Hepatitis C Virus Infections

      • Robert E. Lanford

      Pages 127-140

   4. Immune Signatures and Systems Biology of Vaccines

      • F. M. Buonaguro, M. L. Tornesello, L. Buonaguro

      Pages 141-167

   5. Immune Signatures Associated with the Cancer Bearing State

      • Rebecca J. Critchley-Thorne, Hongxiang Yu, Peter P. Lee

      Pages 169-186

5. Tissue-Specific Patterns Associated with Chronic Inflammatory Processes

   1. Front Matter

      Pages 187-187

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   2. HTLV-1 Infected CD4+CD25+CCR4+ T-Cells Disregulate Balance of Inflammation and Tolerance in HTLV-1 Associated Neuroinflammatory Disease

      • Yoshihisa Yamano, Steven Jacobson

      Pages 189-198

   3. D/2 Predictors of Favorable Outcome in Cancer

      • Zoltán Pós, Jérôme Galon

      Pages 199-210

   4. The Microenvironment of Ovarian Cancer: Lessons on Immune Mediated Tumor Rejection or Tolerance

      • Lana E. Kandalaft, George Coukos

      Pages 211-228

   5. Transcriptional Profiling of Melanoma as a Potential Predictive Biomarker for Response to Immunotherapy

      • Thomas F. Gajewski

      Pages 229-238

This book discusses the mechanisms leading to immune-mediated tissue rejection following the hypothesis that independent of the disease process the final effector mechanism is shared by most (but not all) pathologies and it is relatively simple. The book covers evidence gathered to support the thesis by studies performed in humans during rejection or in experimental models and will focus particularly (but not exclusively) on the analysis of the rejected tissue rather than the systemic circulation. Several disease processes are discussed including example of chronic inflammatory process without resolution of the pathologic process and acute one with resolution of the pathologic process (clearance of pathogen, rejection of tumor) or unwanted tissue destruction (allograft rejection, autoimmunity).

• Cancer Research
• Ena Wang
• Immunologic
• Marincola
• Rejection
• Signatures

• Clinical Center, Dept. Transfusion Medicine, National Institute of Health (NIH), Bethesda, USA

  Francesco M. Marincola

• Bethesda, USA

  Ena Wang

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