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  • Book
  • © 2011

Genes and Cardiovascular Function

  • Bridges the gap between clinical cardiology and genomic study

  • Explores the role of genes in cardiac development

  • Provides a genomic approach to the treatment of the wide spectrum of cardiovascular diseases

  • Written by established investigators, representing the world’s leading experts in the field

  • Includes supplementary material: sn.pub/extras

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Table of contents (24 chapters)

  1. Front Matter

    Pages i-xv
  2. Genes and the Heart

    1. Front Matter

      Pages 1-1
    2. Gene Therapy: Hopes and Problems

      • VladimĂ­r Vonka
      Pages 7-17
  3. Development and Gender

    1. Front Matter

      Pages 19-19
    2. VEGFS, FGFS, and PDGF Coordinate Embryonic Coronary Vascularization

      • Robert J. Tomanek, Lance P. Christensen
      Pages 21-28
    3. The E2F Pathway in Cardiac Development and Disease

      • Jennifer Rueger, Balwant S. Tuana
      Pages 29-41
    4. Cardiac Sodium–Calcium Exchanger Expression

      • Cecilia Hurtado, Thane G. Maddaford, Grant N. Pierce
      Pages 43-56
    5. Scleraxis: A New Regulator of Extracellular Matrix Formation

      • Rushita A. Bagchi, Michael P. Czubryt
      Pages 57-65
    6. Gender Impact on Pathophysiology of the Heart

      • Jane-Lise Samuel, Claude Delcayre, Bernard Swynghedauw
      Pages 67-76
  4. Mitochondrial Diseases

    1. Front Matter

      Pages 77-77
    2. Mitochondrial DNA and Heart Disease

      • Chihiro Shikata, Masami Nemoto, Takanori Ebisawa, Akihiro Nishiyama, Nobuakira Takeda
      Pages 79-84
    3. A Novel Algorithm from Personal Genome to the Pathogenic Mutant Causing Mitochondrial Cardiomyopathy

      • Teruhiko Toyo-oka, Toshihiro Tanaka, Licht Toyo-oka, Katsushi Tokunaga
      Pages 85-92
    4. MELAS Syndrome: Mediated by Impaired Taurinomethyluridine Synthesis

      • Stephen W. Schaffer, Chian Ju Jong
      Pages 93-100
  5. Ischemic Heart Disease

    1. Front Matter

      Pages 101-101
    2. Genetics of Myocardial Infarction

      • Rudolf Poledne, Jaroslav A. Hubacek
      Pages 103-111
    3. Genetic Background of Myocardial Infarction

      • Kouichi Ozaki, Toshihiro Tanaka
      Pages 113-120
    4. Angiotensin Converting Enzyme I/D Polymorphism and Cardiovascular Risk: Disclosed Story

      • Anna Vasku, Jiri Blahak, Daniel Baumgartner, Julie Bienertova-Vasku
      Pages 121-134
    5. PPARs and Myocardial Response to Ischemia in Normal and Diseased Heart

      • Tana Ravingerova, Adriana Adameova, Slavka Carnicka, Tara Kelly, Martina Nemcekova, Jana Matejikova et al.
      Pages 135-148
    6. Genes and Plasma Lipids in Czech Slavic Population

      • Jaroslav A. Hubacek, Rudolf Poledne
      Pages 149-157

About this book

Rapid advances in molecular medicine have led to pronounced new developments in experimental and clinical cardiology.  In the embrace of modern molecular biology and bridging the gap between the clinical and the genomic, cardiovascular medicine has seen major strides in the understanding of the molecular mechanisms that drive disease progression.  The ability to rapidly identify candidate human genes for cardiovascular diseases lends itself to the development of diverse strategies for disease treatment and management.  The wide variety of gene expressions proffers excellent targets for novel therapeutics.  Gene therapy is steadily increasing in viability and represents a fascinating arena of research and clinical focus.

 

This book is based on two international Mendel symposia on “Genes and the Heart,” joint meetings of the Japanese and European sections of the International Academy of Cardiovascular Sciences.  Highlighting selected symposia contributions, this book explores the role of molecular biology and genetics in the basic knowledge, genesis, and clinical interventions of cardiovascular diseases.

Editors and Affiliations

  • Czech Republic, Institute of Physiology, Academy of Sciences of the, Prague, Czech Republic

    Bohuslav Ostadal

  • Jikei University School of Medicine, Tokyo, Japan

    Makoto Nagano

  • St. Boniface General Hospital, Research Centre, Institute of Cardiovascular Sciences, Winnipeg, Canada

    Naranjan S. Dhalla

Bibliographic Information

  • Book Title: Genes and Cardiovascular Function

  • Editors: Bohuslav Ostadal, Makoto Nagano, Naranjan S. Dhalla

  • DOI: https://doi.org/10.1007/978-1-4419-7207-1

  • Publisher: Springer New York, NY

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Science+Business Media, LLC 2011

  • Hardcover ISBN: 978-1-4419-7206-4Published: 09 August 2011

  • Softcover ISBN: 978-1-4899-7804-2Published: 23 August 2016

  • eBook ISBN: 978-1-4419-7207-1Published: 09 August 2011

  • Edition Number: 1

  • Number of Pages: XVI, 264

  • Topics: Cardiology, Medical Biochemistry

Buy it now

Buying options

eBook USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access