Overview
Outlines novel targets for the treatment of cardiovascular diseases
Elucidates the role of biochemical insults and metabolic derangements in altering gene expression
Provides an understanding of the molecular genesis of cardiovascular dysfunction
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Table of contents (27 chapters)
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Front Matter
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Molecular Mechanisms in Heart Disease
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Front Matter
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Cardiac Hypertrophy and Heart Failure
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Front Matter
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Cardiac Hypertophy and Heart Failure
Keywords
About this book
Molecular Defects in Cardiovascular Disease provides an in-depth discussion of the molecular mechanisms underlying the genesis of cardiovascular defects and the implications this has on current and emerging targeted therapeutics. Divided into three sections, this book covers the scientific foundations of our present understanding as well as the array of clinical manifestations and their treatment. The first section covers Molecular Mechanisms of Heart Disease, with discussion of the development of cardiovascular dysfunction. The remaining two sections provide a more clinical focus. The second, Cardiac Hypertrophy and Heart Failure deals with metabolic derangements, Ca2+ handling, and subcellular remodeling.  It illustrates the wide variety of molecular defects which may serve as targets associated with the transition from cardiac hypertrophy to advanced heart failure. The third section, Hypertension and Diabetes, provides molecular rationale for the pathogenesis of hypertension and diabetic cardiomyopathy, as well as highlighting the importance of hormones toward this end.Â
A necessary resource for clinicians and researchers, this book elucidates the experimental basis of the practice of cardiology. It is the culmination of our advances in the understanding of cardiovascular molecular biology and a blueprint for the efficacious use of targeted therapies.
Editors and Affiliations
Bibliographic Information
Book Title: Molecular Defects in Cardiovascular Disease
Editors: Naranjan S. Dhalla, Makoto Nagano, Bohuslav Ostadal
DOI: https://doi.org/10.1007/978-1-4419-7130-2
Publisher: Springer New York, NY
eBook Packages: Medicine, Medicine (R0)
Copyright Information: Springer Science+Business Media, LLC 2011
Hardcover ISBN: 978-1-4419-7129-6Published: 09 August 2011
Softcover ISBN: 978-1-4939-4115-5Published: 23 August 2016
eBook ISBN: 978-1-4419-7130-2Published: 09 August 2011
Edition Number: 1
Number of Pages: XVIII, 382
Number of Illustrations: 47 b/w illustrations, 31 illustrations in colour
Topics: Cardiology, Medical Biochemistry