Overview
- Editors:
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Nektarios Tavernarakis
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Institute of Molecular Biology and Biotechnology (IMBB), Foundation for Research and Technology Hellas (FORTH), Crete, Greece
- Illustrates that aging cells are characterized by alterations in the rate, level and accuracy of protein synthesis compared to young ones, and that mRNA translation is controlled at multiple levels
- Discusses paradoxical situation of autophagy up-regulation in models of premature aging
- Role of mitochondria in protein quality control and the influence of reactive oxygen species
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Table of contents (16 chapters)
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- Ranjana Mehta, Devon Chandler-Brown, Fresnida J. Ramos, Lara S. Shamieh, Matt Kaeberlein
Pages 14-29
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- Niki Chondrogianni, Efstathios S. Gonos
Pages 38-46
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- Kailiang Jia, Beth Levine
Pages 47-60
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- Guillermo Mariño, Alvaro F. Fernández, Carlos López-OtÃn
Pages 61-68
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- Tibor Vellai, Krisztina Takács-Vellai
Pages 69-80
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- Geert Depuydt, Jacques R. Vanfleteren, Bart P. Braeckman
Pages 81-107
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- Karin Luce, Andrea C. Weil, Heinz D. Osiewacz
Pages 108-125
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- Florence Debacq-Chainiaux, Emmanuelle Boilan, Jérémie Dedessus Le Moutier, Geoffroy Weemaels, Olivier Toussaint
Pages 126-137
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- Elise A. Kikis, Tali Gidalevitz, Richard I. Morimoto
Pages 138-159
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- Artemisia M. Andreou, Nektarios Tavernarakis
Pages 160-171
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- Johannes Grillari, Regina Grillari-Voglauer, Pidder Jansen-Dürr
Pages 172-196
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- Joy Alcedo, Wolfgang Maier, Queelim Ch’ng
Pages 197-210
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- Manlio Vinciguerra, Antonio Musaro, Nadia Rosenthal
Pages 211-233
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- Louise Boisen, Peter Kristensen
Pages 234-244
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Back Matter
Pages 245-249
About this book
Aging is loosely defined as the accumulation of changes in an organism over time. At the cellular level such changes are distinct and multidimensional: DNA replication ceases, cells stop dividing, they become senescent and eventually die. DNA metabolism and chromosomal maintenance, together with protein metabolism are critical in the aging process. The focus of this book is on the role of protein metabolism and homeostasis in aging. An overview is provided of the current knowledge in the area, including protein synthesis, accuracy and repair, post-translational modifications, degradation and turnover, and how they define and influence aging. The chapters mainly focus on well-characterised factors and pathways, but new areas are also presented, where associations with aging are just being elucidated by current experimental data. Protein turnover, the balance between protein synthesis and protein degradation are carefully maintained in healthy cells. Chapters 1 and 2 illustrate that aging cells are characterised by alterations in the rate, level and accuracy of protein synthesis compared to young ones, and that mRNA translation, essential for cell growth and survival, is controlled at multiple levels. The theory that growth and somatic maintenance are believed to be antagonistic processes is described in Chapter 3: inhibition of protein synthesis results in decreased rates of growth and development, but also confers an extension of lifespan, as shown for example by the effects of dietary restriction in various models organisms.
Editors and Affiliations
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Institute of Molecular Biology and Biotechnology (IMBB), Foundation for Research and Technology Hellas (FORTH), Crete, Greece
Nektarios Tavernarakis
About the editor
Nektarios Tavernarakis is a Research Director (Professor) at the Institute of Molecular Biology and Biotechnology, in Heraklion, Crete, Greece, heading the Caenorhabditis elegans molecular genetics laboratory. He earned his PhD degree at the University of Crete, studying gene expression regulation in yeast, and trained in C. elegans genetics and molecular biology at Rutgers University, New Jersey, USA. His research focuses on studies of neuronal function and dysfunction, using the nematode Caenorhabditis elegans as a model organism. His main interests are the molecular mechanisms of necrotic cell death in neurodegeneration and senescent decline, the molecular mechanisms of sensory transduction and integration by the nervous system, the interplay between cellular metabolism and aging, and the development of novel genetic tools for C. elegans research. He is the recipient of a European Research Council (ERC ) Advanced Investigator grant award, a European Molecular Biology Organisation (EMBO) Young Investigator award, an International Human Frontier in Science Program Organization (HF SPO) long‑term award, the Bodossaki Foundation Scientific Prize for Medicine and Biology, the Alexander von Humboldt Foundation, Friedrich Wilhelm Bessel research award, and is member of EMBO.
