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Pre-Invasive Disease: Pathogenesis and Clinical Management

  • Book
  • © 2011

Overview

Editors:
  1. Rebecca C. Fitzgerald

    1. , MRC Cancer Cell Unit, Hutchison-MRC Research Centre, Cambridge, United Kingdom

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  • In an era in which preventive medicine is a major concern for consumers, health-policy makers and politicians pre-invasive disease is likely to become a major part of cancer medicine.

  • There are a wide range of issues which need to be discussed in order to bring advances in our understanding to the clinic.

  • It is hoped that this monograph will be a valuable source of information for all those interested in the field.

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Table of contents (23 chapters)

  1. Front Matter

    Pages i-xxii
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  2. Pathogenesis

    1. Front Matter

      Pages 1-1
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    2. Stem Cells in Intraepithelial Neoplasia

      • Nicholas A. Wright
      Pages 3-20

    3. The Inflammatory Tissue Microenvironment and the Early Stages of Malignancy

      • Fran Balkwill
      Pages 21-29

    4. Hereditary Factors and Pre-invasive Disease

      • Paul D. P. Pharoah
      Pages 31-40

    5. Epigenetic Alterations as Contributors to the Pathogenesis, Detection, Prognosis and Treatment of Human Pre-invasive Neoplasia

      • Stefan David, Stephen J. Meltzer
      Pages 41-63

    6. The Progression of Pre-invasive to Invasive Cancer

      • Souzan Sanati, D. Craig Allred
      Pages 65-76

    7. Contribution of the -Omics Era to Our Understanding of Preinvasive Disease and Progression to Cancer

      • Rita A. Busuttil, Alex Boussioutas
      Pages 77-110

    8. Somatic Evolution in Neoplastic Progression and Cancer Prevention

      • Carlo C. Maley, Eva Szabo, Brian J. Reid
      Pages 111-127

  3. Model Systems and Clinical Approaches

    1. Front Matter

      Pages 129-129
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    2. Precancer in Animal Models: Sequentially Acquired or Predetermined?

      • Robert D. Cardiff, Alexander D. Borowsky
      Pages 131-150

    3. Biomarkers for Detection of Intra-epithelial Neoplasia

      • Kareem M. Shariff, Pierre Lao-Sirieix
      Pages 151-166

    4. Molecular Imaging of Cancer and the Implications for Pre-invasive Disease

      • Scott K. Lyons, Kevin M. Brindle
      Pages 167-207

    5. Chemoprevention

      • Richard A. Hubner
      Pages 209-226

    6. Endoscopic Management of Pre-invasive Esophageal Adenocarcinoma

      • Namasivayam Vikneswaran, Kenneth K. Wang
      Pages 227-244

    7. Psychosocial Outcomes of Screening for Cancer and Pre-invasive Disease

      • Robert N. Whistance, Shelley Potter, Mark Eveleigh, Jane M. Blazeby
      Pages 245-268

  4. Disease Specific Examples

    1. Front Matter

      Pages 269-269
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    2. Pre-invasive Disease of the Lung

      • Ornella Belvedere, Anindo K. Banerjee, Pamela Rabbitts
      Pages 271-295

    3. Progress in Early Detection and Management of Oral Dysplasia: Components for a Multifaceted Progression Risk Model

      • Miriam P. Rosin, Catherine F. Poh, S. Y. Catherine Kang, Calum E. MacAulay, Lewei Zhang
      Pages 297-313

    4. Barrett’s Oesophagus

      • Rebecca Fitzgerald
      Pages 315-340
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About this book

This book is written by International experts in their field and should appeal to students and seasoned researchers, to scientists and to clinicians. No prior knowledge of the topic is required to appreciate this text and yet the book charters new territory. New perspectives are given on how our knowledge of cancer development might lead us to reconsider our clinical approach to early detection and prevention of cancer at an individual and population level.

Editors and Affiliations

  • , MRC Cancer Cell Unit, Hutchison-MRC Research Centre, Cambridge, United Kingdom

    Rebecca C. Fitzgerald

About the editor

Rebecca Fitzgerald is a tenured Programme Leader at the Medical Research Council (MRC) Cancer Cell Unit in Cambridge and her research is in Barrett's oesophagus with a particular focus on early cancer detection. She trained at Cambridge University, conducted her doctoral research at Stanford University, California and came to the UK for her post-doctoral research and specialist clinical training at St. Barts and the London Hospitals before returning to Cambridge. Rebecca maintains an clinical active practice as an honorary consultant in Gastroenterology at the University teaching hospital Addenbrooke's and enjoys teaching in her capacity as Director of Studies at Trinity College, Cambridge.

Bibliographic Information

  • Book Title: Pre-Invasive Disease: Pathogenesis and Clinical Management

  • Editors: Rebecca C. Fitzgerald

  • DOI: https://doi.org/10.1007/978-1-4419-6694-0

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media, LLC 2011

  • Hardcover ISBN: 978-1-4419-6693-3Published: 15 October 2010

  • Softcover ISBN: 978-1-4899-8225-4Published: 10 October 2014

  • eBook ISBN: 978-1-4419-6694-0Published: 14 October 2010

  • Edition Number: 1

  • Number of Pages: XXII, 519

  • Topics: Cancer Research, Pharmacology/Toxicology

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