Hox Genes

1. Front Matter

   Pages i-xxiii

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2. Mechanisms of Activity

   1. Front Matter

      Pages 1-1

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   2. Regulation of Hox Activity: Insights from Protein Motifs

      • Samir Merabet, Nagraj Sambrani, Jacques Pradel, Yacine Graba

      Pages 3-16

   3. Cis-Regulation in the Drosophila Bithorax Complex

      • Robert K. Maeda, François Karch

      Pages 17-40

   4. Maintenance of Hox Gene Expression Patterns

      • Samantha Beck, Floria Faradji, Hugh Brock, Frédérique Peronnet

      Pages 41-62

   5. Control of Vertebrate Hox Clusters by Remote and Global Cis-Acting Regulatory Sequences

      • François Spitz

      Pages 63-78

3. Evolution of Hox Genes and Complexes

   1. Front Matter

      Pages 79-79

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   2. The Early Evolution of Hox Genes: A Battle of Belief?

      • Bernd Schierwater, Kai Kamm

      Pages 81-90

   3. Evolution of Hox Complexes

      • David E. K. Ferrier

      Pages 91-100

   4. The Nematode Story: Hox Gene Loss and Rapid Evolution

      • Aziz Aboobaker, Mark Blaxter

      Pages 101-110

   5. Are the Deuterostome Posterior Hox Genes a Fast-Evolving Class?

      • Robert Lanfear

      Pages 111-122

4. Biological Function

   1. Front Matter

      Pages 123-123

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   2. Hox Genes and the Body Plans of Chelicerates and Pycnogonids

      • Wim G. M. Damen

      Pages 125-132

   3. Hox3/zen and the Evolution of Extraembryonic Epithelia in Insects

      • Urs Schmidt-Ott, Ab. Matteen Rafiqi, Steffen Lemke

      Pages 133-144

   4. Hox Genes and Brain Development in Drosophila

      • Heinrich Reichert, Bruno Bello

      Pages 145-153

   5. Homeosis and Beyond. What Is the Function of the Hox Genes?

      • Jean S. Deutsch

      Pages 155-165

5. Back Matter

   Pages 167-169

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In his 1894 book, Materials for the Study of Variation, William Bateson coined the term Homoeosis with the following prose: The case of the modification of the antenna of an insect into a foot, of the eye of a Crustacean into an antenna, of a petal into a stamen, and the like, are examples of the same kind. It is desirable and indeed necessary that such Variations, which consist in the assumption by one member of a Meristic series, of the form or characters proper to other members of the series, should be recognized as constituting a distinct group of phenomena. ...I therefore propose...the term HOMOEOSIS...; for the essential phenomenon is not that there has merely been a change, but that something has been changed into the likeness of something else. The book was intended as a listing of the kinds of naturally occurring variation that could act as a substrate for the evolutionary process and Bateson took his examples from collections, both private and in museums, of materials displaying morphological oddities. Interestingly the person who also coined the term “Genetics” proffered little in the way of speculation on the possible genetic underpinnings of these oddities. It wasn’t until the early part of the next century that these changes in meristic series were shown to be heritable.

• Chromosom
• Gene
• Hox
• Promoter
• Studies
• gene expression
• genes
• genetics

• Developmental Biology, Pierre and Marie Curie University, Paris, France

  Jean S. Deutsch

JEAN S. DEUT SCH, is Emeritus Professor of Genetics and Animal Biology, Université Pierre et Marie Curie, Paris 6, Department (UMR 7622) “Biologie du Développement”. Under the supervision of Prof. P.P. Slonimski, he participated to the birth of mitochondrial genetics of the yeast Saccharomyces cerevisiae. During the ‘80s, he moved to the Institut Jacques Monod in Paris to study developmental genetics of Drosophila melanogaster, focusing on the genetics of the hormonal control of metamorphosis. In 1993, he was the first in France, together with André Adoutte, to undertake evo-devo studies, choosing the cirripedes, which have been Darwin’s favourite animals, as a model, because of their so peculiar body plan. In a second step, his team studied the developmental genetics of other arthropods, including scorpions and pycnogonids. He is author of a number of scientific publications in international journals, and of three textbooks in French on Drosophila and genetics.

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