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Kernicterus

  • Book
  • © 2011

Overview

Authors:
  1. David W. McCandless

    1. Medicine & Science, Chicago Medical School, Rosalind Franklin University of, North Chicago, USA

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  • The book is designed to examine the biochemistry and physiology of bilirubin
  • New concepts relating to the way in which bilirubin is toxic
  • This volume with examine bilirubin's formation, metabolism, transport and excretion in detail
  • Includes supplementary material: sn.pub/extras

Part of the book series: Contemporary Clinical Neuroscience (CCNE)

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Table of contents (24 chapters)

  1. Front Matter

    Pages i-xiv
    Download chapter PDF

  2. Prologue: World Health Concerns

    • David W. McCandless
    Pages 1-9

  3. History of Bilirubin

    • David W. McCandless
    Pages 11-17

  4. Biochemistry and Physiology of Bilirubin

    • David W. McCandless
    Pages 19-31

  5. Premature Birth

    • David W. McCandless
    Pages 33-41

  6. Erythroblastosis Fetalis

    • David W. McCandless
    Pages 43-50

  7. The Gunn Rat Model

    • David W. McCandless
    Pages 51-64

  8. Crigler–Najjar Syndrome

    • David W. McCandless
    Pages 65-79

  9. Neuropathology of Kernicterus

    • David W. McCandless
    Pages 81-93

  10. Bilirubin and Energy Metabolism

    • David W. McCandless
    Pages 95-108

  11. Jaundice and Other Biochemical Changes

    • David W. McCandless
    Pages 109-114

  12. Breast Milk Jaundice

    • David W. McCandless
    Pages 115-120

  13. Jaundice in Malaria

    • David W. McCandless
    Pages 121-131

  14. Jaundice in Congenital Hypertrophic Pyloric Stenosis

    • David W. McCandless
    Pages 133-139

  15. Phototherapy for Hyperbilirubinemia

    • David W. McCandless
    Pages 141-151

  16. Non-phototherapy Treatment

    • David W. McCandless
    Pages 153-160

  17. Hyperbilirubinemia Revisited

    • David W. McCandless
    Pages 161-173

  18. Auditory Brainstem Response

    • David W. McCandless
    Pages 175-187

  19. Progressive Familial Intrahepatic Cholestasis

    • David W. McCandless
    Pages 189-201

  20. Kernicterus in Older Children and Adults

    • David W. McCandless
    Pages 203-208
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About this book

Kernicterus (bilirubin encephalopathy) is a highly interesting example of metabolic encephalopathy. It fills all the characteristics of a metabolic encephalopathy in that it can develop rapidly, produces signature signs and symptoms, and is amenable to successful treatment. In the absence of treatment kernicterus can produce devastating sequelae and death. The present volume will examine the biochemistry and physiology of bilirubin as well as its hepatic metabolism and renal excretion. Chapters will elaborate bodily disposition of bilirubin and its neuropathology. Both early treatments and current therapy will be discussed in detail. Phototherapy will be presented, and its efficacy and influence on incidence thoroughly examined.

Reviews

From the reviews:

“Hyperbilirubinemia and the prevention of development of neurological pathology and/ or death due to kernicterus in newborns is a significant concern for physicians and allied healthcare workers worldwide. … Kernicterus is a worthy addition to the clinical neuroscience literature as a treatise on a condition that preferentially attacks critical brain regions. … it should be read widely by clinicians and public health officers confronted by issues related to the early diagnosis, treatment and rehabilitation of individuals suffering from kernicterus.” (Medical Science Books, May, 2011)

Authors and Affiliations

  • Medicine & Science, Chicago Medical School, Rosalind Franklin University of, North Chicago, USA

    David W. McCandless

About the author

Dr. David W. McCandless is the John J. Sheinin Professor of Anatomy in the Department of Cell Biology and Anatomy at The Chicago Medical School, Rosalind Franklin University, North Chicago, IL, USA. He has over 35 years of laboratory research into basic mechanisms of various metabolic encephalopathies. He serves as Editor-in Chief of the journal Metabolic Brain Disease (Springer), now in its 26th year. Dr. McCandless has been on the faculty or research staff at The University of Vermont College of Medicine, NIH-NINCDS, University of Texas Medical School at Houston, and The Chicago Medical School, and was a visiting professor at Washington University School of Medicine.Dr. McCandless has published in journals such as The J. Clinical Investigation, Nature, Proc. National Academy of Sciences, Amer. J. of Physiology, Brain Research, J. Neurochemistry, Teratology, Epilepsia, Stroke, and many others

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