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The Physical Basis of Biochemistry

The Foundations of Molecular Biophysics

  • Textbook
  • © 2010

Overview

Authors:
  1. Peter R. Bergethon

    1. School of Medicine, Dept. Anatomy & Neurobiology, Boston University, Boston, USA

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  • Grounds students in the basic principles of biochemistry and molecular biophysics

  • Delves into the explosive developments in the area of genomics, and in turn, proteomics, bioinformatics, and computational and visualization technologies

  • Emphasizes the interdisciplinary nature of biophysical chemistry

  • Contains numerous problem sets and examples, and clear illustrations

  • Includes supplementary material: sn.pub/extras

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Table of contents (32 chapters)

  1. Front Matter

    Pages i-xxix
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  2. Principles of Biophysical Inquiry

    1. Front Matter

      Pages 1-1
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    2. Introduction: To the Student – First Edition

      • Peter R. Bergethon
      Pages 3-4

    3. Philosophy and Practice of Biophysical Study

      • Peter R. Bergethon
      Pages 5-22

    4. Overview of the Biological System Under Study

      • Peter R. Bergethon
      Pages 23-55

    5. Physical Thoughts, Biological Systems – The Application of Modeling Principles to Understanding Biological Systems

      • Peter R. Bergethon
      Pages 57-80

    6. Probability and Statistics

      • Peter R. Bergethon
      Pages 81-106

  3. Foundations

    1. Front Matter

      Pages 107-107
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    2. Energy and Force – The Prime Observables

      • Peter R. Bergethon
      Pages 109-123

    3. Biophysical Forces in Molecular Systems

      • Peter R. Bergethon
      Pages 125-190

    4. Physical Principles: Quantum Mechanics

      • Peter R. Bergethon
      Pages 191-242

    5. Chemical Principles

      • Peter R. Bergethon
      Pages 243-268

    6. Measuring the Energy of a System: Energetics and the First Law of Thermodynamics

      • Peter R. Bergethon
      Pages 269-291

    7. Entropy and the Second Law of Thermodynamics

      • Peter R. Bergethon
      Pages 293-326

    8. Which Way Is That System Going? The Gibbs Free Energy

      • Peter R. Bergethon
      Pages 327-350

    9. The Thermodynamics of Phase Equilibria

      • Peter R. Bergethon
      Pages 351-385

  4. Building a Model of Biomolecular Structure

    1. Front Matter

      Pages 387-387
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    2. Water: A Unique Solvent and Vital Component of Life

      • Peter R. Bergethon
      Pages 389-408

    3. Ion–Solvent Interactions

      • Peter R. Bergethon
      Pages 409-439

    4. Ion–Ion Interactions

      • Peter R. Bergethon
      Pages 441-459
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Keywords

About this book

Biological chemistry has changed since the completion of the human genome project. There is a renewed interest and market for individuals trained in biophysical chemistry and molecular biophysics. The Physical Basis of Biochemistry, Second Edition, emphasizes the interdisciplinary nature of biophysical chemistry by incorporating the quantitative perspective of the physical sciences without sacrificing the complexity and diversity of the biological systems, applies physical and chemical principles to the understanding of the biology of cells and explores the explosive developments in the area of genomics, and in turn, proteomics, bioinformatics, and computational and visualization technologies that have occurred in the past seven years. The book features problem sets and examples, clear illustrations, and extensive appendixes that provide additional information on related topics in mathematics, physics and chemistry.

Authors and Affiliations

  • School of Medicine, Dept. Anatomy & Neurobiology, Boston University, Boston, USA

    Peter R. Bergethon

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