Overview
- Authors:
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Constantin A. Bona
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Mount Sinai School of Medicine, New York, USA
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Adrian I. Bot
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Alliance Pharmaceutical Corp., San Diego, USA
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Table of contents (9 chapters)
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- Constantin A. Bona, Adrian I. Bot
Pages 1-10
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- Constantin A. Bona, Adrian I. Bot
Pages 11-23
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- Constantin A. Bona, Adrian I. Bot
Pages 25-33
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- Constantin A. Bona, Adrian I. Bot
Pages 35-49
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- Constantin A. Bona, Adrian I. Bot
Pages 51-83
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- Constantin A. Bona, Adrian I. Bot
Pages 85-97
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- Constantin A. Bona, Adrian I. Bot
Pages 99-108
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- Constantin A. Bona, Adrian I. Bot
Pages 109-120
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- Constantin A. Bona, Adrian I. Bot
Pages 121-141
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Back Matter
Pages 143-179
About this book
Wolf's discovery demonstrating that a reporter gene is expressed in myocytes subsequent to injection of naked DNA, was exploited by immunologists and vaccinologists to develop a new generation of vaccines. This observation galvanized the research and in a short lapse of time, an oceanic volume of knowledge has been accumulated. The research carried out in a variety of animal models showed the efficacy of genetic immunization against viruses, bacteria, and some parasites by the ability to induce a strong priming effect resulting from long-lasting persistence of plasmid as episomes. Furthermore, it was demonstrated that newborn or infant immune unresponsiveness to classical vaccines can be corrected by genetic immunization. The applications of genetic immunization for prophylaxis of infections was extended to immunotherapy, namely, cancerous, auto immune, and allergic diseases. Immunologists have provided pertinent information on the cellular basis of the immune responses elicited by genetic immunization, and molecular biologists have established the molecular basis of intrinsic adjuvant properties of plasmids.
Authors and Affiliations
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Mount Sinai School of Medicine, New York, USA
Constantin A. Bona
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Alliance Pharmaceutical Corp., San Diego, USA
Adrian I. Bot
