Scientific and Clinical Applications of Magnetic Carriers

1. Front Matter

   Pages i-xv

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2. The Mystery and History of Magnetism

   1. The Mystery and History of Magnetism

      • Urs Häfeli

      Pages 1-10

3. Preparation and Modification of Biodegradable Magnetic Particles

   1. Preparation and Application of Monosized Magnetic Particles in Selective Cell Separation

      • Wenche S. Prestvik, Arvid Berge, Preben C. Mørk, Per M. Stenstad, John Ugelstad

      Pages 11-35

   2. Synthesis, Characterization, and Use of New Solid and Hollow, Magnetic and Non-Magnetic, Organic-Inorganic Monodispersed Hybrid Microspheres

      • Shlomo Margel, Sigalit Gura, Hanna Bamnolker, Boaz Nitzan, Tami Tennenbaum, Beni Bar-Toov et al.

      Pages 37-51

   3. Preparation and Characterization of Magnetic Nanospheres for in Vivo Application

      • Cordula Grüttner, Joachim Teller, Wolfgang Schütt, Fritz Westphal, Carl Schümichen, Bernd-R. Paulke

      Pages 53-67

   4. Synthesis Studies on Paramagnetic Polystyrene Latex Particles

      • Bernd-R. Paulke, Norbert Buske, Supandi Winoto-Morbach

      Pages 69-76

   5. Microspheres for Use in a Novel Electromagnetic Bioadhesion Testing System

      • B. Hertzog, T. Mottl, D. Yim, E. Mathiowitz

      Pages 77-92

   6. Novel Magnetic Microcarriers on the Basis of Poly(Vinyl Alcohol) for Biomedical Analysis

      • Detlef Müller-Schulte, Frank Füssl, Marcel De Cuyper

      Pages 93-107

   7. Magnetic Oxide Particles Prepared by Glass Crystallization

      • W. Schüppel, R. Müller, C. Ulbrich, H. Steinmetz

      Pages 109-115

   8. Nanosized Ferrite Particles

      • M. P. Pileni, N. Feltin, N. Moumen

      Pages 117-133

4. Characterization of Magnetic Particles

   1. Intravenously Injected Particles

      • Rainer H. Müller, Martin Lück, Stephan Harnisch, Kai Thode

      Pages 135-148

   2. Analysis of Microspheres in Living Cells by Confocal Microscopy

      • Stine-Kathrein Kraeft, Urs O. Häfeli, Lan Bo Chen

      Pages 149-161

   3. Techniques for Electro- and Magnetokinetic Particle Characterization

      • Wolfgang Schütt, Cordula Grüttner, Bernd Paulke, Phil Goetz, Nobuya Hashimoto

      Pages 163-170

   4. Quantification of Maghemite Nanoparticles in Biological Media by Ferromagnetic Resonance and Its Alteration by Conjugation with Biological Substances

      • Maria de Fatima Da Silva, François Gendron, Jean Claude Bacri, Jacky Roger, Jean-Noël Pons, Michel Robineau et al.

      Pages 171-176

   5. Use of ESR, Mössbauer Spectroscopy, and Squid-Magnetometry for the Characterization of Magnetic Nanoparticles on the Base of Metal Iron and Its Implications in Vivo

      • Olga M. Mykhaylyk, Oleg N. Razumov, Alexandre K. Dudchenko, Yuri V. Pankratov, Eduard K. Dobrinsky, Vladimir N. Sosnitsky et al.

      Pages 177-204

5. Applications in Cell Separation and Analysis

   1. Physics of Magnetic Cell Sorting

      • Maciej Zborowski

      Pages 205-231

   2. Microfabricated Flow System for Magnetic Cell and Particle Separation

      • Gert Blankenstein

      Pages 233-245

   3. Continuous-Flow Magnetic Cell Sorting Using Soluble Immunomagnetic Label

      • Maciej Zborowski, Lee R. Moore, Liping Sun, Jeffrey J. Chalmers

      Pages 247-260

   4. Isolation of Megakaryocytes Using Magnetic Cell Separation

      • Sarah Baatout

      Pages 261-268

6. Applications in Molecular Biology

   1. Magnetic Separation in Molecular Biology

      • Marie Bosnes, Arne Deggerdal, Anne Rian, Lars Korsnes, Frank Larsen

      Pages 269-285

The discovery of uniform latex particles by polymer chemists of the Dow Chemical Company nearly 50 years ago opened up new exciting fields for scientists and physicians and established many new biomedical applications. Many in vitro diagnostic tests such as the latex agglutination tests, analytical cell and phagocytosis tests have since become rou­ tine. They were all developed on the basis of small particles bound to biological active molecules and fluorescent and radioactive markers. Further developments are ongoing, with the focus now shifted to applications of polymer particles in the controlled and di­ rected transport of drugs in living systems. Four important factors make microspheres interesting for in vivo applications: First, biocompatible polymer particles can be used to transport known amounts of drug and re­ lease them in a controlled fashion. Second, particles can be made of materials which bio­ degrade in living organisms without doing any harm. Third, particles with modified surfaces are able to avoid rapid capture by the reticuloendothelial system and therefore en­ hance their blood circulation time. Fourth, combining particles with specific molecules may allow organ-directed targeting.

• biomedical application
• biomedical applications
• endothelium
• imaging
• living systems

• The Cleveland Clinic Foundation, Cleveland, USA

  Urs Häfeli, Maciej Zborowski

• University of Rostock, Rostock, Germany

  Wolfgang Schütt

• micro caps, Rostock, Germany

  Joachim Teller

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